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126  structures 19397  species 7  interactions 29872  sequences 570  architectures

Clan: BRCT-like (CL0459)

Summary

BRCT like Add an annotation

The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage.

This clan contains 5 families and the total number of domains in the clan is 29872. The clan was built by P Coggill.

Members

This clan contains the following 5 member families:

BRCT BRCT_2 LIG3_BRCT PTCB-BRCT RTT107_BRCT_5

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
BRCT (PF00533) 24910 (83.4%) View
PTCB-BRCT (PF12738) 3173 (10.6%) View
BRCT_2 (PF16589) 1305 (4.4%) View
RTT107_BRCT_5 (PF16770) 329 (1.1%) View
LIG3_BRCT (PF16759) 155 (0.5%) View
Total: 5 Total: 29872 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 7 interactions for this clan. More...

Interacting families
A B
BRCT ACC_central
BRCT
DNA_ligase_IV
NIF PTCB-BRCT
PTCB-BRCT PTCB-BRCT
XLF BRCT
XRCC4 BRCT

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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