Sequence alignment for CL0459

PF12738

MCPH1_HUMAN/9-75---------------VV--AYV-------E-----VWSSNGTENYSK-TF---TTQLVD-MGAKV---------------
ECT2_MOUSE/179-242---------------LV--LCF-------T-----GFRKKE...ELV-KL---VTLVHH-MGGVI---------------
A2R3M9_ASPNC/121-184---------------LS--ICI-------T-----GFEDMS...LRN-RI---QDTVTA-HGAEF---------------
A7F1C2_SCLS1/119-182---------------LR--ISL-------T-----GCDDTA...ERQ-DI---AEKIKA-NGGEY---------------
A7S5M3_NEMVE/449-511---------------MS--ISV-------T-----GFTGQE....RQ-LV---RNMVFM-IGANY---------------
A9RB53_PHYPA/468-530---------------VK--FCV-------S-----QYSERD....RK-LL---RKLCYV-LKVKF---------------
B0DMV8_LACBS/502-564---------------VR--MSL-------S-----GLDEAD....AH-GI---KRLMRA-IGLVI---------------
B2VU23_PYRTR/350-412---------------YK--ISI-------S-----SYTGEA....RV-YL---ENLIKA-SGAEF---------------
B2W796_PYRTR/229-291---------------IT--ITP-------G-----HMPASL....RE-SL---QRSVER-IGAKI---------------
B2W7P6_PYRTR/114-177---------------LK--ICL-------T-----GFDNPD...QRK-SI---QDKVDA-NGGEY---------------
B3RL44_TRIAD/702-764---------------MV--IAV-------T-----GYTGKE....RD-KV---KMIINA-IGANY---------------
B4H593_DROPE/186-250---------------VV--VYV-------D-----VRSGNDN..RSD-GV---KSIIAD-MGAQI---------------
B4KSD3_DROMO/76-140---------------VI--VYV-------E-----VRTGNDN..RSE-GV---KNIITK-LGAQA---------------
B6HL54_PENCW/128-191---------------LK--ICI-------T-----GFSDLP...FRA-YM---QKTTEE-NGAEY---------------
B6Q6C3_PENMQ/111-174---------------LS--ICV-------T-----GFEDPS...YRT-YL---QETTIA-NGAEF---------------
C0NFA4_AJECG/121-184---------------LS--ICL-------T-----GFDDMN...HRN-SL---QKLITE-NGAEF---------------
C1FFW2_MICSR/561-624---------------LR--IST-------S-----LYDEDV....KS-SV---NMLCHL-LGAKY---------------
C1GTX0_PARBA/624-691---------------VV--LVF-------S-----GVLPLGTDMQSA-DI---SMWAKS-FGATI---------------
C4M4C9_ENTHI/17-80---------------YV--ICV-------S-----GYSTDE....RV-LL---GGMIEQ-FGGIY---------------
C5FMN4_ARTOC/111-174---------------LS--ICI-------T-----GFENTD...FRS-HL---EKTVSE-NGGEF---------------
RAD4_SCHPO/105-167---------------CR--VCL-------T-----NIGQPE....RS-RI---ENYVLK-HGGTF---------------
Q014F9_OSTTA/116-179---------------AR--IVV-------D-----GYVGQD....KL-DL---VELIEA-AGGTH---------------
Q16W28_AEDAE/219-283---------------VC--IYV-------E-----VRSGTDN..RSD-GI---RDHLVS-LGAKV---------------
Q1K5Z2_NEUCR/339-401---------------MK--ITL-------S-----NYGGDA....RV-YL---ENLITA-AGATY---------------
Q2H787_CHAGB/324-387---------------LL--CCM-------T-----GFEDPD...ERE-QI---IGQIEA-NGGLY---------------
Q4CP92_TRYCC/1-63---------------ML--VTT-------T-----AIYGEE....LD-RI---KKDLHQ-QGVTY---------------
Q4PHX3_USTMA/599-667---------------LR--LML-------L-----GFDPDSP..ELY-HA---QKLVVE-MGGSI---------------
Q5TRD6_ANOGA/110-173---------------VI--TCF-------T-----GIRKKD...ELT-HL---VHLIHS-MGGSI---------------
Q6CN34_KLULA/351-414---------------LK--ATY-------T-----NYYGEQ....RY-YI---QLLVEA-LGGIC---------------
PAXI1_MOUSE/102-165---------------LT--ACL-------S-----QVSSED....RS-AL---WALVTF-HGGSC---------------
Q6Z553_ORYSJ/10-72---------------VV--ATV-------S-----GYHGDE....RH-RL---VRLIAE-TGASY---------------
Q9U7D8_DROME/117-180---------------VV--TCF-------T-----GIRKKD...ELT-KL---VNLIHS-MGGCI---------------
B9GSH3_POPTR/111-175---------------IT--MCL-------T-----GYQRQD....RD-DI---MTMVGL-MGAHF---------------
D7SMI0_VITVI/4-66---------------II--ATV-------S-----GYHGVE....RS-NL---IKLISQ-TGAKY---------------
F4I701_ARATH/188-251---------------LT--ICV-------T-----RIPADE....RK-GM---EKVISE-YGGSY---------------
F4I701_ARATH/667-729---------------LC--ICS-------S-----QHNEKN....VE-LL---RNLSVV-LGADF---------------
F6XFW7_XENTR/204-267---------------CT--ICV-------T-----GLNSLD....RK-EV---QRLTTL-HGGEY---------------
H0ZRM8_TAEGU/5-67---------------..--..V-------E-----VWSSSRTENYSK-TF---EQQLLD-MGAEV---------------
H3C8W0_TETNG/80-141---------------.I--MSV-------T-----GFVDAD....RD-DL---KLMAYL-TGARY---------------
I1QYC0_ORYGL/209-271---------------.N--ICI-------T-----KLNVDE....RR-EL---AKIIVQ-NGGQY---------------
I1QYC0_ORYGL/675-736---------------.R--FCV-------S-----QYEEKD....RL-LL---KNLCFI-LGSKF---------------
Q4WQC2_ASPFU/345-407---------------LK--ISL-------S-----NYVGEA....RI-YL---ENLITA-AGAEC---------------
Q7JUM5_DROME/187-251---------------IV--VYV-------E-----VRTGNDN..RSE-GV---KSIIAK-MGAQV---------------
U5GIH0_POPTR/4-66---------------VV--ATV-------S-----GYHGSE....RF-NL---IKLISQ-SGASY---------------

PF00533

Y4211_ARATH/1089-1168VFQDQE------H-EPK--FFI.......V-----SGPRSQ----RN-EY...QQIIRR-LKGKCC..............
MDB1_SCHPO/384-455NKHTNL------V-TSS--FNL........-----......----TK-PM...KSFIRR-NGLRV...............
MDB1_SCHPO/485-573HRRTCF------N-GKR--LYIT.....KA-----IRDSMV----GD-SIHGLYSILET-SGAEIV..............
ECT2_MOUSE/266-341FKVPPF------Q-DCI--LSF.......L-----GFSDEE----KH-SM...EEMTEM-QGGSY...............
PAXI1_HUMAN/701-776PGGKPC------S-QHI--ISV.......T-----GFVDSD----RD-DL...KLMAYL-AGAKY...............
PAXI1_HUMAN/860-934KLTPEL------T-PFV--LFT........-----GFEPVQ----VQ-QY...IKKLYI-LGGEV...............
TDT_HUMAN/27-111PQDIKF------Q-DLV--VFIL.....EK-----KMGTTR----RA-FL...MELARR-KGFRV...............
RAD9_YEAST/994-1109RTGNVF------D-KCI--FVL........-----TSLFEN----RE-EL...RQTIES-QGGTVIESGFSTLFNF..TH
XRCC1_HUMAN/538-616ELPDFF------Q-GKH--FFL......YG-----EFPGDE----RR-KL...IRYVTA-FNGEL...............
Q93161_CAEEL/981-1063NVPQKF------P-TTS--FHI........-----..WIDE----RT-DINITNQFMEK-FQAIT...............
PARP4_HUMAN/1-81MVMGIF------A-NCI--FCLK.....VK-----YLPQQQ----KK-KL...QTDIKE-NGGKF...............
TOPB1_HUMAN/101-176VYNMVM------S-DVT--ISC.......T-----SLEKEK----RE-EV...HKYVQM-MGGRV...............
TOPB1_HUMAN/195-271FKCPIF------L-GCI--ICV.......T-----GLCGLD----RK-EV...QQLTVK-HGGQY...............
TOPB1_HUMAN/354-431APEDLL------D-GCR--IYL.......C-----GFSGRK----LD-KL...RRLINS-GGGVR...............
TOPB1_HUMAN/548-620TEEGLF------S-QKS--FLV.......L-----GFSNEN----ES-NI...ANIIKE-NAGKI...............
TOPB1_HUMAN/641-725TGMTPL------E-DCV--ISF.......S-----QCAGAE----KE-SL...TFLANL-LGASVQEYF...........
TOPB1_HUMAN/900-978EAPKPL------H-KVV--VCV.......S-----KKLSKK----QS-EL...NGIAAS-LGADY...............
TOPB1_HUMAN/1260-1338THEELK------K-QYI--FQL.......S-----SLNPQE----RI-DY...CHLIEK-LGGLVI..............
Q20129_CAEEL/451-529GLGDLF------E-NCM--FYI.......C-----GVDESR----ME-KW...RRFLNE-TGATR...............
Q20129_CAEEL/587-659TQVGIF------S-YHT--YCV......HC-----SVDQEV----SD-DL...KEKIPL-NGGKL...............
Q20129_CAEEL/679-749PPILIF------N-QRG--FQL.......K-----CKDPFL----RD-RV...RDIIED-NGGRI...............
DNLJ_HAEIN/592-668ASENLF------K-DKT--VVL......TG-----TLTQMG----RN-EA...KALLQQ-LGAKV...............
DNLI4_CANAL/673-756VESDLF------S-GIE--FLIM....SDK-----READGE----VT-TIEEMKAMVKQ-YGGKI...............
Q20129_CAEEL/128-204VYSSVF------Q-DVK--ISF.......T-----GLNLTK----KQ-EL...YEKIGW-MCGVV...............
O76369_CAEEL/929-1023GKNALL------D-AIR--EVN........-----KTNVMK----AL-KMGSYINAYNK-HGNTALHVAV..........
PAXI1_MOUSE/94-170ESCQIF------F-GLT--ACL.......S-----QVSSED----RS-AL...WALVTF-HGGSC...............
PAXI1_MOUSE/588-668PEESFL------L-GCV--FAIA.....DY-----PEQMSD----KQ-LLATWKRIIQA-HGGTV...............
PARP1_MOUSE/385-463PADKPL------S-NMK--ILT.......L-----GKLSQN----KD-EA...KAVIEK-LGGKL...............
DNLI4_HUMAN/654-730KISNIF------E-DVE--FCV......MS-----GTDSQP----KP-DL...ENRIAE-FGGYI...............
DNLI4_HUMAN/814-898RRHTVY------L-DSY--AVIN....DLS-----TKNEGT----RL-AIKALE..LRF-HGAKV...............
O16568_CAEEL/1044-1144MRPKLL------E-QCG--FHI........-----.LETEL----LK-NREGWEEVIKL-FGGSV...............
TDT_MONDO/27-111IYEIKF------H-EFV--LFIL.....EK-----KMGATR----RT-FL...TDLARK-KGFRV...............
O16229_CAEEL/378-460NVPQQF------P-VSS--FHI........-----..WMDE----KT-DDKLTNAFMEK-FPSIT...............
DNLJ_HELPY/577-652KSSSVF------N-NKT--IVL......TG-----TLSK.P----RQ-EY...AQMLEN-LGAKI...............
DNLJ_BACSU/590-666DSDSYF------A-GKT--IVL......TG-----KLEELS----RN-EA...KAQIEA-LGGKL...............
DNLJ_MYCLE/607-683SVLPTC------E-GLT--IVV......TG-----SLAGFS----RD-DA...KEAIVA-RGGKV...............
O44844_CAEEL/154-256KRPPLF------Y-GFN--FTILP...TTN-----RRMQAT----RE-FW...NRIIEG-FGGTCSM.............
DNLJ_BORBU/583-659GENKLL------A-GKK--FCI......TG-----TFNGYS----RS-II...IDKLKN-KGAIF...............
BRCA1_RAT/1588-1669PKERAE------R-DIS--MVV........-----..SGLT----PK-EVMIVQKFAEK-YRLAL...............
BRCA1_RAT/1701-1787SQEKLF------E-GLQ--IYC......CE-----PFTNMP----KD-EL...ERMLQL-CGASVVK.............
RFC1_SCHPO/236-313GNSDCL------S-GIS--FVI......TG-----ILETLT----RQ-EA...TDLIKQ-YGGKV...............
DNLJ_AQUAE/619-696KVADVL------K-GKT--FVF......TG-----TLDCCS----RE-KA...GEIVEM-LGGKF...............
CHS5_CANAL/164-246HKMTDL------S-GIT--VCLG....DLT-----PNDQFN----KE-DI...EEALKN-MGAKY...............
DNLJ_TREPA/562-642QAESPL------R-GKS--FCF......SG-----SLRNGD----RA-TI...H.RIRA-LGGVV...............
DNLJ_CHLTR/581-657DKEAPL------Q-GKV--FVL......TG-----TLQQMT----RT-QA...EERIRC-LGGKV...............
O96271_PLAF7/208-298FDYLPF------H-NQK--FVI......TG-----VFKNFT----RD-EL...QSKIKE-HGGSV...............
PESC_LEIMA/317-390KVRELF------R-GLT--FFI........-----.SREVP----AK-HF...ALVINA-CGGRV...............
DNLJ_ECOLI/593-669EIDSPF------A-GKT--VVL......TG-----SLSQMS----RD-DA...KARLVE-LGAKV...............
PARP1_CHICK/382-460PQDKPL------T-NMK--ILT.......L-----GKLSKN----KE-EV...KNIVEE-LGGKM...............
DNLJ_THET8/589-664KGGEAL------K-GLT--FVI......TG-----ELSR.P----RE-EV...KALLRR-LGAKV...............
DNLJ_ZYMMO/645-721LASSPL------S-GKI--IVF......TG-----SLQKIT----RD-EA...KRQAEN-LGAKV...............
RAD4_SCHPO/2-79GSSKPL------K-GFV--ICC.......T-----SIDLKQ----RT-EI...STKATK-LGAAY...............
RAD4_SCHPO/97-172HFLPTL------F-KCR--VCL.......T-----NIGQPE----RS-RI...ENYVLK-HGGTF...............
RAD4_SCHPO/392-473SLVPYF------N-GLS--IHL........-----..TGFK----GE-ELSHLKKALTI-LGAVV...............
RFC1_DROME/232-309GSPDCL------S-GLT--FVV......TG-----VLESME----RE-EA...ESVIKE-YGGKV...............
TDT_CHICK/27-111GYEIKF------N-KLV--IFIM.....QR-----KMGMTR----RT-FL...MELARS-KGFRV...............
BRCA1_HUMAN/1642-1723STERVN------K-RMS--MVV........-----..SGLT----PE-EFMLVYKFARK-HHITL...............
BRCA1_HUMAN/1756-1842QDRKIF------R-GLE--ICC......YG-----PFTNMP----TD-QL...EWMVQL-CGASVVK.............
RFC1_YEAST/153-230GKPNCL------L-GLT--IVF......TG-----VLPTLE----RG-AS...EALAKR-YGARV...............
RT107_YEAST/2-103STSLLF------E-QLN--FLI.......L-----VAAEAE----LP-IAHSTRKLLMD-NSCNNC..............
RT107_YEAST/117-213NPFHLL------R-DCQ--VYI........-----SKSSFN----KC-EYILYSDLLHL-LGGTL...............
RT107_YEAST/261-352PNKTLF------K-NHH--FAI.......S-----PDLNFF----TP-LYWFLKGFIED-LDGKV...............
RT107_YEAST/370-453FHAKLF------T-SKE--LTVA.....YT-----NYFGSQ----RF-YI...QRLVEI-LGGLS...............
YPT4_CAEEL/930-1012CVPEKF------P-VSS--FHI........-----..YIED----RT-DDNVTNEFTTK-FQSIT...............
YPT4_CAEEL/1049-1141ATTPFL------Y-GVH--VAL........-----..CMKN----CP-YLASLTAIIQG-QGGTM...............
DPB11_YEAST/111-207FSFKYL------H-NFN--IFI.......G-----RITDTN----IT-SIDSLVRSIKK-LGCSSYNYQNFVIK......
DNLJ_SYNY3/591-667TDSGKL------K-GKT--FVL......TG-----TLPNLS----RL-EA...QELIEQ-SGGKV...............
RHP9_SCHPO/535-640SNQLIF------D-DCV--FAFS....GPV-----HEDAYD----RS-AL...ETVVQD-HGGLVLDTGLRPLFNDPFKS
FCP1_YEAST/499-580LKQKVF------Q-NCY--FVFSG...LIP-----LGTDIQ----RS-DI...VIWTST-FGATS...............
DNLI4_YEAST/681-767PISNIF------A-GLL--FYVLSDYVTED-----TGIRIT----RA-EL...EKTIVE-HGGKLIY.............
DNLI4_YEAST/836-928FPLFLF------S-NRI--AYV......PR-----RKISTE----DD-II...EMKIKL-FGGKI...............
Q09615_CAEEL/251-326NVSRIM------E-GFS--VFV.......N-----GYTDPP----AL-VI...RDLMIS-HGGEY...............
BRC1_SCHPO/14-91HYTIIF------K-VVA--YYS........-----.ALQPN----QN-ELRKKELFIKN-DGKAL...............
BRC1_SCHPO/105-183NPYLLF------K-GIC--ASS.......C-----QIDSYQ----SS-LI...DDALET-FGGRF...............
BRC1_SCHPO/216-293LFRNVL------H-GKR--IYF.......S-----NDLNLP----TN-FRHSLQKFSVG-IGAKI...............
BRC1_SCHPO/311-386PSVGFL------K-DQM--VAV.......T-----NYTDAA----RI-YL...EKLLLA-CGATY...............
CHS5_YEAST/166-249HKMTDM------S-GIT--VCLG....PLD-----PLKEIS----DL-QI...SQCLSH-IGAR................
Q18104_CAEEL/407-489QVPEIF------P-VSS--FHI........-----..FIDK----ET-DDNVTNKFLLV-FQSIT...............
XRCC1_MOUSE/315-390ELGKIL------Q-GVV--VVL.......S-----GFQNPF----RS-EL...RDKALE-LGAKY...............
Q94046_CAEEL/514-600DPELYL------T-GIH--FHCFD..SEKL-----FEDKLD----RK-NL...EFMIKY-HGGDIEFE............
Q94046_CAEEL/620-694ENFRPY------L-GKL--FSL.......S-----GFDSSE----RA-AI...SFMAEM-MGAKI...............
DNLJ1_STRCO/643-719EGPRPL------E-GLT--VVV......TG-----TLENFT----RD-GA...KEALQS-RGAKV...............
DNLJ_RICPR/610-686REQNIL------T-GKI--VVF......TG-----SLSTIS----RV-EA...KEIAEK-LGAKV...............
PARP1_ARATH/394-471SRSERL------A-DLK--VSI........-----...AGN----TK-ERQPWKKRIEE-AGAEF...............
D0MI04_RHOM4/636-709...SPV------R-GKT--FVL......TG-----ALPHLT----RK-EA...EELIKR-AGGRV...............
H9KXM3_CALJA/403-478..ENCL------E-GLT--FVI......TG-----VLESIE----RD-EA...KSLIER-YGGKV...............
Q5AZH7_EMENI/325-400..ENCL------A-GLT--FVF......TG-----VLDTLG----RE-EG...QALVKR-YGGKV...............

PF16759

H2ZXR2_LATCH/884-956TLLDIF------T-GVR--LYL-------P-----PSV.ED----FS.KL---QRYFIA-YDGDL---------------
F6S783_MACMU/933-1005VLLDIF------T-GVR--LYL-------P-----PST.PD----FS.RL---RRYFVA-FDGDL---------------
D2W3T0_NAEGR/824-906SLCDLF------T-DMV--MYI-------H-----KDV.PA----LK.MH---TRYIIA-FDG.I---------------
H3CY38_TETNG/809-881TLLDIF------S-GVK--LFL-------P-----LTV.QD----FD.KL---RRYFVA-YDGEL---------------
G3QCE5_GASAC/909-981TLLDVF------S-GVK--LFL-------P-----VSV.QD----FH.KL---RRYFVA-YDGDV---------------
Q1RL58_CIOIN/781-858FLNDIF------L-GVK--IFI-------P-----TDV.EK----RK.KM---ERHILA-FNGDV---------------
E0VGK6_PEDHC/807-896PLPNIF------T-GCV--IQI-------P-----KEY.KN----YD.LL---RRYLIA-YDGKL---------------
H0Z3J4_TAEGU/853-925PLLDIF------T-GVR--LYL-------A-----PSV.KD----FD.RI---RRYFIA-FDGDL---------------
H2MK50_ORYLA/283-355TLLDIF------G-GVK--LFL-------P-----ASI.QD----AD.RL---RRYFVA-YDGDL---------------
C3XPG8_BRAFL/848-925VLPDVF------C-GIK--LFL-------P-----DTV.EN----YA.LL---RRYFVA-YDGDI---------------
D6WBL1_TRICA/353-434SIPNYF------E-NVR--LFL-------E-----EGVKER----HA.QW---VKYFIA-YGGSV---------------
F2US92_SALR5/1151-1238PLKNVF------H-GVT--CFI-------S-----DAV.PD----YS.KA---YRYGTA-FGAEL---------------
D6WBL2_TRICA/760-840PLPDYF------H-NIK--VVL-------E-----DKVREK----QW.DL---IRYFIA-YGGQI---------------
H2Z1K6_CIOSA/772-849FLKDTF------E-GVK--IFI-------P-----NDV.QN----RS.KM---VRYIKA-NNGDV---------------
E9CDE4_CAPO3/1228-1306.LPDTF------V-GTN--ILL-------S-----PQLSPD----VKRRL---QRYIVA-YGGTI---------------
F6WXI9_XENTR/905-977TLLDIF------T-GVK--LHI-------P-----STL.DD----FA.KL---RRYFIA-FDGDL---------------
J9JUI3_ACYPI/779-867RLPDLF------T-GIR--VVV-------P-----DSI.SK----NT.FL---.RYFIA-YGGTP---------------

PF16589

RAP1_SCHPO/1-104-MSFTF.TKSDGS.SIL..FAVSK......-----NFEHIR-------GF---KNAIDC.FKGKI---------------
M5FSC1_DACSP/182-279-TVRFFTVNDDGK.SVQAAFWVQP......-----EIKERT-------KL---IRAINR.HGGRI---------------
H3C9A2_TETNG/9-93-...........C.SVL..VELKT.....L-----PIKEKR-------SL---KAAITE.NGGTI---------------
Q08CM6_DANRE/45-136-IMTVF....ENC.TVV..FDVKN.....V-----PFKEKQ-------KL---KSALLE.NGGNI---------------
R4XAV8_TAPDE/3-87-GSNLF.TDPDGE.PLR..FFLP......M-----SLASRS-------TF---KDKIEH.NGGVL---------------
C4V7R6_NOSCE/195-261-HKNLF........................-----.....N-------LL---KRLIIE.HGGSR---------------
M2Y325_GALSU/16-125-PDNLF..QINCE.PLR..FFVGL.....S-----S..QKN-------HV---ELLIKK.RGGLV---------------
B7QFB5_IXOSC/8-93-SRNLF.TRYDGG.PMC..FSLIP.....C-----A..ERK-------EI---REIIEY.GGGML---------------
A3LW54_PICST/41-121-KSTLF.TNREGR.SIR..FYMEYS....E-----P..RRL-------HY---KALIET.HGGVL---------------
D3BEV4_POLPA/10-104-NNDLF......K.SIV..FYLIG.....V-----PIGEQN-------KI---KTLLKK.CGGSI---------------
J4I894_FIBRA/337-429-DEEIF.KTDAGD.SMM..FYVQ......I-----ETRNRG-------EV---VQSIRK.HGGKI---------------
F0WYP1_9STRA/24-103-ETEIF......S.GMQ..FYISRL....V-----KNEQGR-------EV---GHLIQK.NGGVV---------------
C5M515_CANTT/70-152-PPPIF.VTPDGR.SMR..FTIQHG....E-----P..RRA-------EF---VQKIIT.HGGAV---------------
A5DYD1_LODEL/66-146-RNQIF.VTRDGK.PIA..FYLGFN....E-----P..NRA-------KY---VTAIIE.NGGFI---------------
G8BJX2_CANPC/111-190-HAHIF.VTSDNK.PMP..FFIPFD....E-----P..NRN-------KY---KRMIMQ.NGGYL---------------
H8X494_CANO9/94-173-QASIF.VTSDNK.PIP..FFIPFD....E-----P..DRT-------KY---RRMIIQ.NGGYL---------------
G3AM46_SPAPN/45-124-QRNLF.IDRDGR.SLL..FYIPRN....E-----P..HRS-------HY---RQLIIS.YGGVV---------------
M3K224_CANMX/72-151-PKTIF.VDKDNK.TML..FYIPKE....E-----P..NRI-------KY---RELIIK.HGGLL---------------
C4YKS1_CANAW/89-168-PKPIF.VDKDGK.SML..FYIPED....E-----P..NRN-------KY---RDLIIR.YGGVI---------------
B9WCR9_CANDC/86-165-PKPIF.IDKDGK.SMY..FYIPED....E-----P..NRN-------KY---RDLIIT.HGGVL---------------
G1XSA5_ARTOA/13-91-DDRLF......S.GLS..FFLTSL....C-----P..TRD-------YF---RKLLET.NGGKI---------------
E6R8V2_CRYGW/313-411-GAGLF.TVAGAV.PLS..FWVYG.....G-----P..RAR-------TL---EIVITHAGGGIL---------------
F1KRF2_ASCSU/907-985-EEQAF........................-----...SKR-------EV---RQMIES.HGGIV---------------
B3RX95_TRIAD/6-86-NRNLF.QDADGK.PMK..FYIKP.....C-----P..TKG-------KV---RPLIES.CGGQV---------------
A7RVV1_NEMVE/15-100-NSCLFLNDEDGS.PIL..FYITP.....G-----P..LKK-------RL---KTLIEV.RGGIV---------------
H2KSC7_CLOSI/10-91-PPTLF.VLPNGT.AMT..FTLHR.....C-----P..DFF-------TL---LPLVVA.GGGVL---------------
G5C0W9_HETGA/11-94-IPPLF.VRADRS.PLS..FYVQP.....S-----P..IKR-------WL---STVILH.GGGTV---------------
F1R0Q3_DANRE/33-119-SPVLF.LDPGGQ.SMR..FYVRP.....G-----P..TKM-------QL---HPLITS.GGGNL---------------
H3AZ33_LATCH/22-105-SRTLF.VREDGA.PVW..FYLRP.....G-----P..AKK-------SL---APLIRH.GGGGL---------------
H3DBF1_TETNG/17-103-SPVLF.MGVDGK.PMS..FFLRP.....S-----P..AKA-------EL---QRLIVA.GGGVL---------------
H2URR3_TAKRU/14-100-SPVLF.MDVDGQ.PMN..FFLCP.....G-----P..VKR-------KL---QPLIVA.GGGVL---------------
M4ASB2_XIPMA/13-99-SPVLF.LTVEGE.PMS..FFLRP.....G-----P..HKQ-------KL---QPLITD.GGGIL---------------
I3KA69_ORENI/14-100-SPVLF.MTVEGE.PMN..FFLRP.....G-----P..IKR-------KL---QPLISA.GGGML---------------
G3NA35_GASAC/14-100-SPVLF.MTVDGE.PMT..FFLRP.....G-----P..AKL-------KL---QPLITA.GAGVL---------------
J8ZTC5_EDHAE/363-439-SINIF......K.GLS..FYIEK......-----...QIN-------NL---VWLIQY.CGGEI---------------
M7PBU4_PNEMU/1-86-MPNIF.KNTDGT.NME..FFLTH......-----TIAERV-------SL---RNSIEE.YGGKT---------------
F6WHH4_CIOIN/18-102-KHRLFVLETGTS.SYK.............-----...YKQ-------DL---RSKITK.NGGTI---------------
J7S744_KAZNA/61-148-KNKFW......T.GMR..FFINREDTAHD-----NVNDAD-------RL---AALVTT.YGGEL---------------
I2GXL7_TETBL/69-154-KIGIF......T.GLS..FYIPTEKTAYD-----STLTIE-------QL---KDSLIN.NNAII---------------
C5DD36_LACTC/53-131-QQDIF......Q.DLG..FFIAH.....D-----E..SRQ-------EL---EQLVSG.HGGTV---------------
G0WD26_NAUDC/165-250-KKLVF......E.NIK..FFINRDSGAID-----SSTEAD-------QL---ERLITA.NGGEI---------------
G8ZLB0_TORDC/16-100-EDGLF......S.GMR..FYLNCGA...D-----SGAESR-------QL---GDLIES.RGGEV---------------
F2Z6A0_CANGA/80-168-EKGIF......N.GMV..FYLNRDSNAHD-----SIIIVE-------QL---KNLILL.NGGDI---------------
G0VI01_NAUCC/119-206-ISTLF......Q.GMN..FFMNRNNDAHD-----SAHDVD-------QL---ARLIMA.HSGNV---------------
H2APC0_KAZAF/72-157-NSEPL......V.GMK..FFLNRDSDAHD-----SINDIE-------QL---ARLIKS.NGGQI---------------
C5DTR6_ZYGRC/67-154-QGLIF......Q.GMS..FYVNRDSSAND-----SANDID-------RL---HQLVES.RGGTV---------------
A7TIC7_VANPO/66-154-IAGIF......Q.NLK..FYINTEQDAYD-----TVNDIE-------TL---TRLIQS.NGGTV---------------
G8C1X2_TETPH/45-136-NHSLF......K.GYS..FFINTKPDAYG-----KKSDIN-------SL---TRLALS.HEGTI---------------
D8Q0I4_SCHCM/674-767-ESDLF......K.GMK..FVVISDPKART-----GEEDRK-------KL---MKLIRS.HGGQC---------------
J6EKB0_SACK1/356-448-AASLF......S.NFS..FYVGR.....E-----V..PID-------IL---EFLILS.CGGNI---------------
B0EKW8_ENTDS/154-233-GSGLF......S.GMV..FYIQR.....E-----V..PRH-------PV---AFVIET.LGGII---------------
L2GQH2_VITCO/272-348-KAGIF......K.NMR..FFI.......D-----VKSISE-------QI---AFVILS.LDGEV---------------
A7ATP9_BABBO/280-357-TEGIF.......TGMR..FFISS.....E-----V..PLV-------PT---SLVITS.AGGIL---------------

PF16770

F2QSE6_PICP7/699-801QDSAVVETEVILPSKYS--LHAITTGC......TITLSKVH------------LKKLST-VGIKI---------------
A5DNV2_PICGU/524-631ERATESPPPKKKKAVTN--VNAIITGS.ED...EITLSRSD------------LAKLSQ-VGIKV---------------
G8YM20_PICSO/621-729DTPKNKKRKVEETRPYD--IKGIVTGC.EG...ILTLSKQD------------LNALKD-IGIKI---------------
G3AYG3_CANTC/572-671SKKQKAFTPEKTASQLS--MVAIMTGC.ES...EVDLTRED------------IANLKN-YGIKI---------------
M3JFE1_CANMX/645-744TTSETTTTPIKKPTQYK--TIAMMTGC.ES...EISLEDPD------------ISKLQT-LGVLI---------------
Q6BZF3_DEBHA/634-743KAKKRKTESPRPDTDTK--IVAVITGC.EN...EITLTRQD------------TQNLNH-IGVKV---------------
A3LN41_PICST/588-699QKKPKKTTLPEEATKFR--ITAIMTGC.ES...EINLNKND------------LSKLSN-IGIKV---------------
G3AMT0_SPAPN/577-678LLSSPPVKKHKPNKKCE--IIAVMTGC.ES...IIDLSADD------------IANLQN-VGVEI---------------
C5M5V1_CANTT/627-732SEDEIEVLEENKVVEFD--IIGIMTGC.ES...EIELNKQD------------HEHLKN-LGIKI---------------
B9WAI6_CANDC/655-759ESSQSGISKAKKPTHYH--IIAIMTGC.EQ...IIELNKSD------------LQKLQA-IGIKI---------------
Q5ALY1_CANAL/652-759ELSQSDFLKTKKKTQYH--IIAIMSGC.EQ...IIELSKSD------------IQKLRT-IGIKI---------------
A5DUV3_LODEL/733-836DILEMKEHKRQRTNECD--IVAILTGC.EL...QINLTKND------------CAKLQT-VGIKI---------------
H8WXP5_CANO9/622-725TGSEGLDVKRLRTDECG--IIAIMTGC.EQ...DIELTKSD------------YAKLQS-IGIKV---------------
Q6FR08_CANGA/839-962NPYTCNSSNQTISLNIG--LNAICTGF.SL...E.DLTDIE------------KEILRL-VGIKL---------------
I2K400_DEKBR/545-655EPAKKKAKHDXNXKAYN--VIAVMTGS......DMDLTSAD------------TKKLNR-VGITI---------------
K0KF71_WICCF/641-748ALPKAKKAKKTPSTPYN--IIAIATGW......ELNFNRSD------------TQILSN-LGITL---------------
Q6FL29_CANGA/598-706RSKRSKMPERSLNKMYD--IRAVCTNC.LK.....TLSARD------------KKVLSQ-LGIDI---------------
J7S1V3_KAZNA/537-650APHEKPIDNRDSHRPYQ--IEAVTTNC.LE.....RLTAEE------------KQRLGE-LGVSL---------------
H2AQS3_KAZAF/756-868RFLTDDSDIENSFPIYD--IRAVSTNC.LE.....NLKELD------------IKVLDV-LGIKI---------------
I2H240_TETBL/888-996LCSVTHTNIPLKRYPYN--INAICTGY.EE.....NYTDLE------------LCLLRL-LGIRI---------------
G8BNV8_TETPH/805-917QVASSIDYDMSKNKIYD--IRAVCTGC.LE.....NISTVD------------LELLKA-LGIHI---------------
C5DDJ9_LACTC/677-784LETVAGRPKGKSMKPYD--IIAVCTGC.HE.....EIDEFD------------LELLRR-VGVTI---------------
A7TEV9_VANPO/803-912VLRCMDGSQSTEENIYN--IRAVCTGC.LD.....KINEID------------LVILRL-IGIYI---------------
G0W872_NAUDC/775-885VSKLRRDGERENVLQFS--INAISTGC.HE.....DIGILD------------LEILNQ-FGIRL---------------
J7R641_KAZNA/728-836STVESETFLKTVRHTYS--IVAYITGC.LD.....DMTALD------------KAILKL-VGIKI---------------
G0VDU3_NAUCC/653-763KDAKEILSKIVIDKKFS--IVGTCTGC.HE.....DISKLD------------LEILRL-LGVKI---------------
H2AVG7_KAZAF/692-804REILSGIFQESPSKIFN--LNCLCTGC.HE.....EISELD------------LELLKL-LGVKI---------------
C8Z9V1_YEAS8/820-932TKAEKILARFNELPNYD--LKAVCTGCFHD.....GFNEVD------------IEILNQ-LGIKI---------------
Q6CN34_KLULA/656-761KADEMVSYLNISHKPYK--IKAVLTNC.HE.....NLSNLD------------ILILSK-IGVII---------------
M9N343_ASHG1/635-742PYLEEYSDTTGGRLPYD--IKAVFTNC.HE.....NITDLD------------KEILRQ-LGIIL---------------
G8JP23_ERECY/643-750HVDISKGSKGRQKLPYD--IKAVCTSC.HD.....DISELN------------LEILKQ-IGIVI---------------
G8ZYK9_TORDC/770-884SQADESVAFGRKKQLYH--IEAVCTGS.HE.....TIKDLD------------KVLLGL-LGIKI---------------
C5DS98_ZYGRC/912-1023TGSEGAQHHRSKKLPYN--INAVTTGL.SG.....NIGELD------------LTILRL-LGITI---------------
I2GZK5_TETBL/782-893IDLLFSKKSPKSCLPYN--IEAVCTGC.PE.....LNNELE------------LHILKR-LGIKI---------------
G0VGC1_NAUCC/666-782DSILSILDDSVELPLYD--MNAICTGC.HE.....SINGAD------------QEILRE-LGIRI---------------
G8BX11_TETPH/765-877ISSITSSNPLRSKLVYN--IDAICTGC.LD.....YISDLD------------KKLLYY-LGVRI---------------
M7PGB1_PNEMU/569-665KTIAKFFPTNKDFRDYS--VRILVTGY.KDW......DNQM------------EKALLT-IGIAT---------------
G0S8X0_CHATD/601-703QDKRPAKRAKTSLPEAD--MRICLTGY.KRWAGDKSSEEAD------------RKKLRA-LGIQI---------------
G2QQU9_THITE/602-704EHKRPAKRAKVSLPEVD--MRICLTGY.KRWVGDKATEEAD------------RRKLRL-LGIQI---------------
G9MPP7_HYPVG/606-708EEDRPAKKSRPSLPGIE--MRIILTGF.TRWVGNQNKEDQD------------RRKLRD-LGIQI---------------
N4VGU8_COLOR/580-682EDRPSKKRKSSALPDVE--MRIVLTGY.GRWVSSQAKEDVE------------RRKLRD-MGILI---------------

PF12738

MCPH1_HUMAN/9-75----------S------KTF.NKQ------------VTHVI----F...KDG--------------------YQST----
ECT2_MOUSE/179-242----------R------KEC.NSK------------VTHLV----A...NCT--------------------QGEK----
A2R3M9_ASPNC/121-184----------R------KDL.TKN------------VTHLI----A...RNT--------------------EGEK----
A7F1C2_SCLS1/119-182----------D------GNL.TKQ------------ITHLI----S...FRT--------------------EGNK----
A7S5M3_NEMVE/449-511----------T------GYL.MRT------------NTHLV----C...RSS--------------------ESLK----
A9RB53_PHYPA/468-530----------S------ETL.NSK------------ITHLL----C...KVQ--------------------AGEK----
B0DMV8_LACBS/502-564----------P------PVF.SKK------------ATHLL----C...PSG--------------------TGLK----
B2VU23_PYRTR/350-412----------T------KTF.KQE------------NTHLI----A...AHK--------------------NSEK----
B2W796_PYRTR/229-291----------S------DNV.RID------------TTHFV----C...TEG--------------------RGPS----
B2W7P6_PYRTR/114-177----------H------GDL.TKS------------VTHLI----A...ATP--------------------SGKK----
B3RL44_TRIAD/702-764----------T------PHL.SRK------------NTHLI----C...KSP--------------------SGEK----
B4H593_DROPE/186-250----------N------DRL.LRN------------TTHVI----F...KDG--------------------LLST----
B4KSD3_DROMO/76-140----------N------DRL.LRN------------TTHVV----F...KDG--------------------LLST----
B6HL54_PENCW/128-191----------R------KDL.TKT------------VTHLI----A...RNS--------------------DGEK----
B6Q6C3_PENMQ/111-174----------R------KDL.TKT------------VTHLI----A...QQA--------------------SGAK----
C0NFA4_AJECG/121-184----------R------RDL.TKS------------VTHLI----A...RSG--------------------YGQK----
C1FFW2_MICSR/561-624----------T------ERLGRNK------------NTHLV----V...PYA--------------------EGKK----
C1GTX0_PARBA/624-691----------S------HKI.NLR------------TTHLV----A...GRN--------------------RTAK----
C4M4C9_ENTHI/17-80----------M------EDMESRS------------VSFLL----S...KGL--------------------TSDK----
C5FMN4_ARTOC/111-174----------R------KDL.TKT------------VTHLV----A...RVG--------------------EGKK----
RAD4_SCHPO/105-167----------C------PDL.TRD------------VTHLI----A...GTS--------------------SGRK----
Q014F9_OSTTA/116-179----------E------EEM.TSK------------TTHLV----C...YRA--------------------GSSA----
Q16W28_AEDAE/219-283----------N------DKL.YKD------------TTHVI----F...KDG--------------------LLST----
Q1K5Z2_NEUCR/339-401----------T------KTM.KAD------------NTHLI----T...ARM--------------------NGEK----
Q2H787_CHAGB/324-387----------T------GDL.TKQ------------VTHLI----V...YKP--------------------EGRK----
Q4CP92_TRYCC/1-63----------V------AEL.TTS------------TNVLI----A...GRS--------------------EGGK----
Q4PHX3_USTMA/599-667----------I------THWKAES------------LTHVV----CATQESF--------------------EGKH----
Q5TRD6_ANOGA/110-173----------R------KGM.DTK------------VTHLI----C...NSS--------------------GGEK----
Q6CN34_KLULA/351-414----------S------TEL.TKK------------NTHLI----S...PIA--------------------SGKK----
PAXI1_MOUSE/102-165----------Q------LNL.NKK------------CTHLI----V...PEP--------------------KGEK----
Q6Z553_ORYSJ/10-72----------V------GAM.SRS------------ITHLV----C...WRL--------------------EGKK----
Q9U7D8_DROME/117-180----------K------KDL.NTK------------TTHLI----C...NHS--------------------GGEK----
B9GSH3_POPTR/111-175----------S------KPLVANR------------VTHLI----C...YKF--------------------EGEK----
D7SMI0_VITVI/4-66----------V------GTM.SRS------------ITHLV----C...WKF--------------------EGRK----
F4I701_ARATH/188-251----------S------AEL.TKS------------CTHLI----A...DAA--------------------EGDK----
F4I701_ARATH/667-729----------V------ERL.TRK------------VTHLI----C...NFA--------------------KGDK----
F6XFW7_XENTR/204-267----------T------GQLKMNE------------STHLI----V...QEA--------------------KGQK----
H0ZRM8_TAEGU/5-67----------S------KTL.NKH------------VTHVV----F...KDG--------------------RLST----
H3C8W0_TETNG/80-141----------T------GYL.CRS------------NTVLI----C...KEP--------------------VGLK----
I1QYC0_ORYGL/209-271----------S------ANL.TRR------------CTHLV----S...NEP--------------------GGDK----
I1QYC0_ORYGL/675-736----------T------EKA.TKK------------VTHLI----C...KFA--------------------SGPK----
Q4WQC2_ASPFU/345-407----------T------KTL.KQE------------NTHLV----T...AHG--------------------HSEK----
Q7JUM5_DROME/187-251----------K------DRL.TRT------------TTHVV----F...KDG--------------------LLST----
U5GIH0_POPTR/4-66----------V------GAM.SNS------------TTHLV----C...WKF--------------------EGRK----

PF00533

Y4211_ARATH/1089-1168........RDS------HQW.SYQ------------ATHFI....A---PEI...................RRTEK....
MDB1_SCHPO/384-455..........Q------ESV.TDE------------TDFVI....L---GSP.................PLRRTHK....
MDB1_SCHPO/485-573........GDI------KRA.QEK------------DTIIL....A---QPDN...............DQEGRNMS....
ECT2_MOUSE/266-341..........L------PVG.DER------------CTHLI....V---EEN....................TVKD....
PAXI1_HUMAN/701-776..........T------GYL.CRS------------NTVLI....C---KEP....................TGLK....
PAXI1_HUMAN/860-934...........------AES.AQK------------CTHLI....A---SKV...................TRTVK....
TDT_HUMAN/27-111..........E------NEL.SDS------------VTHIV....A---ENNSG.............SDVLEWLQA....
RAD9_YEAST/994-1109PLAKSLVNKGN------TDN.IRE------------LALKL....A---WKPHSLFADCR..FACLITKRHLRSLK....
XRCC1_HUMAN/538-616..........E------DNM.SDR------------VQFVI....T---AQE..................WDPSFE....
Q93161_CAEEL/981-1063..........S------DEA.NSN------------TTHVI....V---KTDEN.............GALETDSLD....
PARP4_HUMAN/1-81..........S------FSL.NPQ------------CTHII....L---DNA.................DVLSQYQ....
TOPB1_HUMAN/101-176..........Y------RDL.NVS------------VTHLI....A---GEV....................GSKK....
TOPB1_HUMAN/195-271..........M------GQLKMNE------------CTHLI....V---QEP....................KGQK....
TOPB1_HUMAN/354-431..........F------NQL.NED------------VTHVI....V---GDY..................DDELKQ....
TOPB1_HUMAN/548-620..........M------SLL.SRT------------VADYA....V---VPL.......................L....
TOPB1_HUMAN/641-725.....VRKSNA------KKG.MFA------------STHLI....L---KER....................GGSK....
TOPB1_HUMAN/900-978..........R------WSF.DET------------VTHFI...YQ---GRP..................NDTNRE....
TOPB1_HUMAN/1260-1338.........EK------QCF.DPT------------CTHIV....V---GHP...................LRNEK....
Q20129_CAEEL/451-529..........V------AKF.TSA------------TNVVV....V---SPN.................QQERITI....
Q20129_CAEEL/587-659..........M------DDP.DYA------------EFVIF....G---HSG............................
Q20129_CAEEL/679-749..........V------EQL.EPK------------DFIIM....I---DAE............................
DNLJ_HAEIN/592-668..........S------GSV.SSK------------TDFVI....A---GDA...................AG.SK....
DNLI4_CANAL/673-756..........V------NSV.DLA------------TNYQI....M---VIT..................ERELPV....
Q20129_CAEEL/128-204..........G------DAL.YHE------------TTHLV....T---EKA...................EQTEK....
O76369_CAEEL/929-1023.....RKAHTS------DEQ.MST------------TTHCV....V---KTNEN.............GILETESLE....
PAXI1_MOUSE/94-170..........Q------LNL.NKK------------CTHLI....V---PEP...................KGEKY....
PAXI1_MOUSE/588-668..........D------PTF.TSR------------CTHLL....C---ASQ....................VSSM....
PARP1_MOUSE/385-463..........T------GSA.NKA------------SLCIS....I---KKE.................VEKMNKK....
DNLI4_HUMAN/654-730..........V------QNP.GPD------------TYCVI....A---GSE....................NIRV....
DNLI4_HUMAN/814-898..........V------SCL.AEG------------VSHVI....I---GEDH...............SRVADFKA....
O16568_CAEEL/1044-1144..........V------QDI.EAD------------DEKTPKPYWT---LSSFYKKKKWEQRSCIILKHSDSKIEK....
TDT_MONDO/27-111..........E------NEL.SNS------------VTHIV....A---ENNSG.............SDVLAWLKT....
O16229_CAEEL/378-460..........S------DEA.MLT------------TTHVV....V---KVNPA.............GVLETDDLS....
DNLJ_HELPY/577-652..........S------SSV.SAK------------TDFLI....A---GEN...................PG.SK....
DNLJ_BACSU/590-666..........T------GSV.SKN------------TDLVI....A---GEA...................AG.SK....
DNLJ_MYCLE/607-683..........A------GSV.SKK------------IAYVV....V---GDL...................PG.YK....
O44844_CAEEL/154-256.......SPIP------GEA.GKI------------PYHLV....K---RNLKVPSASID..SSVVLYFNDSVLHE....
DNLJ_BORBU/583-659..........N------TCV.TGS------------LDFLI....V---GEK...................AG.SK....
BRCA1_RAT/1588-1669..........T------DVI.TEE------------TTHVI....I---KTDAE..............FVCERTLK....
BRCA1_RAT/1701-1787.......ELPL------LTR.DTG------------AHPIV....L---VQPS...............AWTEDNDC....
RFC1_SCHPO/236-313..........T------GAP.SVR------------TDFIL....L---GEN...................AGPRK....
DNLJ_AQUAE/619-696..........S------NSV.TSK------------TDYLV....V---GKD...................PGATK....
CHS5_CANAL/164-246...........------..P.VQQ------------QVKVD....T---THFLC.............TRENKQNPE....
DNLJ_TREPA/562-642..........R------TSV.TRD------------LSYLIFESLS---QPY...................RTAQK....
DNLJ_CHLTR/581-657..........S------SSV.SKS------------TYAVI....A---GSE...................AG.GK....
O96271_PLAF7/208-298..........M------TAV.STK------------TNYLV....H---GEY...................LEDGRLFNE
PESC_LEIMA/317-390.........AT------DYV.PSN------------ITHVV....V---DRPA................LP.........
DNLJ_ECOLI/593-669..........A------GSV.SKK------------TDLVI....A---GEA...................AG.SK....
PARP1_CHICK/382-460..........T------TTA.NKA------------TLCIS....T---QKE.................VEKMSKK....
DNLJ_THET8/589-664..........T------DSV.SRK------------TSYLV....V---GEN...................PG.SK....
DNLJ_ZYMMO/645-721..........A------SSV.SKK------------TNLVV....A---GEA...................AG.SK....
RAD4_SCHPO/2-79..........R------SDF.TKD------------VTHLI....A---GDF..................DTPKYK....
RAD4_SCHPO/97-172..........C------PDL.TRD------------VTHLI....A---GTS....................SGRK....
RAD4_SCHPO/392-473..........H------EFL.GVQ------------RSILL....V---NTNEP..............FSMKTRFK....
RFC1_DROME/232-309..........M------TVV.GKK------------LKYLV....V---GEE...................AGPKK....
TDT_CHICK/27-111..........E------SEL.SDS------------VTHIV....A---ENNSY.............PEVLDWLKG....
BRCA1_HUMAN/1642-1723..........T------NLI.TEE------------TTHVV....M---KTDAE..............FVCERTLK....
BRCA1_HUMAN/1756-1842.......ELSS------FTL.GTG------------VHPIV....V---VQPD...............AWTEDNGF....
RFC1_YEAST/153-230..........T------KSI.SSK------------TSVVV....L---GDE...................AGPKK....
RT107_YEAST/2-103........QIY------ELY.NEN------------LKDVK....T---DKDWFMNKFGPQTVHFVISNTINFPFY....
RT107_YEAST/117-213..........V------NYI.SNR------------TTHVI....V---QSPQDPIIATV.SKLTFGSFSSSSTNK....
RT107_YEAST/261-352...........------.......------------TPLSF....S---DDLKSVYQAFPDIDCYIGHSANSPILE....
RT107_YEAST/370-453..........T------PEL.TRK------------NTHLITKSTI---GKK..................FKVAKK....
YPT4_CAEEL/930-1012..........S------DEA.MIT------------TTHVV....V---KTTED.............GILETDDLN....
YPT4_CAEEL/1049-1141...........------..L.DKF------------PDKDA....F---NKGSHPYLHKNLGPIFLLHDGTGDLDL....
DPB11_YEAST/111-207.DTSSHNDDDD------QGQ.NGQ------------ISIFV....T---DTL....................LGAR....
DNLJ_SYNY3/591-667..........T------SSV.STK------------TDYVL....L---GDK...................PG.SK....
RHP9_SCHPO/535-640KQKKLRHLKPQ------KRS.KSW------------NQAFV....V---SDT..................FSRKVK....
FCP1_YEAST/499-580..........T------PDI.DYL------------TTHLI....T---KNP..................STYKAR....
DNLI4_YEAST/681-767.......NVIL------KRH.SIG------------DVRLI.....---....................SCKTTTE....
DNLI4_YEAST/836-928...........------....TDQ------------QSLCN....L---IIIPYTDPILRKDCMNEVHEKIKEQIK....
Q09615_CAEEL/251-326..........H------CYY.QHG------------ITSYT....I---ASS....................IATA....
BRC1_SCHPO/14-91.........SF------PYD.WKL------------ATHVI....C---DDF....................SSPN....
BRC1_SCHPO/105-183..........S------KGL.MKS------------MTHLF....T---YSG.................MGAKCKK....
BRC1_SCHPO/216-293..........A------ESI.NDC------------DIFIG.....---....................LKRDTIE....
BRC1_SCHPO/311-386..........T------KDL.KPT------------NTLLI....A---ASS....................YGQK....
CHS5_YEAST/166-249...........------..P.LQR------------HVAID....T---THFVCN...........DLDNEESNEE....
Q18104_CAEEL/407-489..........S------MEP.LPN------------TTHCI....V---QTEFD.............GTLKTNDLD....
XRCC1_MOUSE/315-390..........R------PDW.TPD------------STHLICAFA.---.......................NTPK....
Q94046_CAEEL/514-600.......ASKF------HER.IHQ------------ITHVL....V---DSC....................RNTN....
Q94046_CAEEL/620-694..........T------PFL.ARQ------------NDLLI....A---KQP.....................ADK....
DNLJ1_STRCO/643-719..........T------GSV.SKK------------TSFVV....V---GDN...................PG.SK....
DNLJ_RICPR/610-686..........T------ASV.SLN------------TDLVI....A---GVN...................GG.SK....
PARP1_ARATH/394-471..........H------ANV.KKG------------TSCLV....V---CGL.................TDIRDAE....
D0MI04_RHOM4/636-709..........A------SSV.SRN------------TDYVV....V---GEN....................PGSK....
H9KXM3_CALJA/403-478..........T------GNV.SKK------------TNYLV....M---GRD...................SGQSK....
Q5AZH7_EMENI/325-400..........T------TAP.SGK------------TSFVV....L---GSD...................AGPSK....

PF16759

H2ZXR2_LATCH/884-956----------V------PEFDTSG-----.......ATHTV----S---D.L----------..............----
F6S783_MACMU/933-1005----------V------QEFDMTS-----.......ATHVL----G---S.R----------..............----
D2W3T0_NAEGR/824-906----------V------ESSFSDD-----.......ITHII----T---SSS----------RIT.......PEIA----
H3CY38_TETNG/809-881----------V------PEYDAAA-----.......ATHTM----A---E.P----------..............----
G3QCE5_GASAC/909-981----------V------QDYEVAT-----.......ATHTL----A---E.P----------..............----
Q1RL58_CIOIN/781-858----------L------GNDQFKE-----.......ATHIV----Q---C.D----------............SV----
E0VGK6_PEDHC/807-896----------Y------DPEKETS-----VENGKNKVTHVI----H---LNK----------VG........KIVK----
H0Z3J4_TAEGU/853-925----------V------SEGDTAS-----.......ATHVL----G---D.I----------..............----
H2MK50_ORYLA/283-355----------V------ADYDAAS-----.......ATHTL----A---P.P----------..............----
C3XPG8_BRAFL/848-925----------V------QDYAMSQ-----.......ATHVV----E---D.P----------............EQ----
D6WBL1_TRICA/353-434----------L------TNDKPEE-----.......ATHVL----H---LKD----------T..........ISQ----
F2US92_SALR5/1151-1238----------V------N.AMGGD-----.......VTHVV----V---PDL----------DVDKW..DAATKSA----
D6WBL2_TRICA/760-840----------C------KHGESEN-----.......ATHMI----H---LNS----------M...........VP----
H2Z1K6_CIOSA/772-849----------L------KENELKL-----.......ATHVV----Q---S.D----------............SV----
E9CDE4_CAPO3/1228-1306----------V------KPAELDL-----.......CTHVV----V---PSL----------D...........SA----
F6WXI9_XENTR/905-977----------V------PEYDLPT-----.......ATHVM----G---REP----------..............----
J9JUI3_ACYPI/779-867----------L------NSSNELA-----.......PTHVI----V---QKK----------EHNRSSEKPMKEEK----

PF16589

RAP1_SCHPO/1-104----------EF..LSFDKVDPTK-----HD.......YYL........VAE----------------------------
M5FSC1_DACSP/182-279----------S......HSMSDCH-----Y........VVI........RSS----------------------------
H3C9A2_TETNG/9-93----------C......FVVNKQC-----.........SLI........LTS----------------------------
Q08CM6_DANRE/45-136----------S......YTINKEC-----.........SFV........VTS----------------------------
R4XAV8_TAPDE/3-87----------VH.....SELMNNI-----.........IKI........GDP----------------------------
C4V7R6_NOSCE/195-261----------V......SLIDKNV-----D........YIL........TSS----------------------------
M2Y325_GALSU/16-125----------L......GKLPESF-----KL.....QGMVLDLDENGLPCDP----------------------------
B7QFB5_IXOSC/8-93----------VQ.....PGVNPRA-----.........IRL........VPA----------------------------
A3LW54_PICST/41-121----------L......DHSVTDC-----.........FWL.........ST----------------------------
D3BEV4_POLPA/10-104----------A......LQVNKSV-----.........HYLITTTEEVEKAS----------------------------
J4I894_FIBRA/337-429----------V......PDIPQAD-----VV.......ILA........QHT----------------------------
F0WYP1_9STRA/24-103----------S......SKSSSKV-----.........IEL........VDQ----------------------------
C5M515_CANTT/70-152----------I......EPGKDVI-----.........SLG........QQD----------------------------
A5DYD1_LODEL/66-146----------T......EGGVENV-----.........IYL........TSH----------------------------
G8BJX2_CANPC/111-190----------A......EGEVDGI-----.........VCV........TSK----------------------------
H8X494_CANO9/94-173----------A......EGGVENM-----.........IYV........TSK----------------------------
G3AM46_SPAPN/45-124----------T......DRLIPSC-----.........YFL........SNN----------------------------
M3K224_CANMX/72-151----------V......DKQIPTA-----.........YHL........SNN----------------------------
C4YKS1_CANAW/89-168----------V......EKGFPTV-----.........ILL........SNN----------------------------
B9WCR9_CANDC/86-165----------V......EKYFPSI-----.........IPL........SNN----------------------------
G1XSA5_ARTOA/13-91----------C......KTDRSAD-----.........LII........SDH----------------------------
E6R8V2_CRYGW/313-411----------T......SSTLAGF-----.........LILPLPLSSRITNP----------------------------
F1KRF2_ASCSU/907-985----------SD...DFTKIPAGE-----KV.......LLI........ADT----------------------------
B3RX95_TRIAD/6-86----------I......VHPTDGV-----.........IRL........AEP----------------------------
A7RVV1_NEMVE/15-100----------S......SKITPGV-----DT.......ILL........QES----------------------------
H2KSC7_CLOSI/10-91----------E......KSVRTNS-----.........ILL........AEA----------------------------
G5C0W9_HETGA/11-94----------C......WVQEPGA-----.........VLL........AQP----------------------------
F1R0Q3_DANRE/33-119----------C......RNQEPGA-----.........ILL........IDP----------------------------
H3AZ33_LATCH/22-105----------C......RVQESGA-----.........VLL........ADT----------------------------
H3DBF1_TETNG/17-103----------C......SVQQPGA-----.........ILL........MNP----------------------------
H2URR3_TAKRU/14-100----------C......SVQQPGS-----.........ILL........IDP----------------------------
M4ASB2_XIPMA/13-99----------C......SVQVPGA-----.........ILL........IDP----------------------------
I3KA69_ORENI/14-100----------C......NVQQPGA-----.........ILL........TDP----------------------------
G3NA35_GASAC/14-100----------C......KVQQPGA-----.........ILL........LEP----------------------------
J8ZTC5_EDHAE/363-439----------V......SSPEHAD-----.........FFV........GEN----------------------------
M7PBU4_PNEMU/1-86----------SIIN...DNKNKDL-----.........IIL........GDP----------------------------
F6WHH4_CIOIN/18-102----------S......YLLTKKS-----H........YVV........SQP----------------------------
J7S744_KAZNA/61-148----------I......DEVPDST-----DQ...DG.KALV........ISP----------------------------
I2GXL7_TETBL/69-154----------L......NQLPSQD-----SV......DSFV........ICP----------------------------
C5DD36_LACTC/53-131----------L......SELPSGK-----SN......KEFV........VST----------------------------
G0WD26_NAUDC/165-250----------V......KALPQQA-----SS......DFFV........VSP----------------------------
G8ZLB0_TORDC/16-100----------V......DKLPEDV-----K....EGEKLYV........VAL----------------------------
F2Z6A0_CANGA/80-168----------V......NKLPNKD-----SA...EAKHIIV........VSP----------------------------
G0VI01_NAUCC/119-206----------L......ASLPEDT-----TD...VS.NVYV........ISP----------------------------
H2APC0_KAZAF/72-157----------L......EDVPQSA-----KTN......VVI........VSP----------------------------
C5DTR6_ZYGRC/67-154----------L......HEMPIKE-----LI...GP.GVFI........VSP----------------------------
A7TIC7_VANPO/66-154----------L......ENIPQQN-----SI...DFSKFFV........ISP----------------------------
G8C1X2_TETPH/45-136----------L......DELPDST-----SMTGEQRSKFYV........VSP----------------------------
D8Q0I4_SCHCM/674-767----------PQ....FAKDPAAI-----.........VVY........NGT----------------------------
J6EKB0_SACK1/356-448----------ISEAAL.DRIENKK-----DIDMSKITHQIV........DRP----------------------------
B0EKW8_ENTDS/154-233----------V......DNVDDES-----IT.......HQV........GER----------------------------
L2GQH2_VITCO/272-348----------A......SYGQAK.-----.........FII........TET----------------------------
A7ATP9_BABBO/280-357----------S......DIDNATH-----.........VVI........DRP----------------------------

PF16770

F2QSE6_PICP7/699-801---------.V------DNPSSKV.............NCII--------SPS------------------IMRTEK----
A5DNV2_PICGU/524-631---------.N------KELTKAH...........RVEVII--------APR------------------ILRTEK----
G8YM20_PICSO/621-729---------.I------PDVTQAS...........DLDTII--------APK------------------ILRTAK----
G3AYG3_CANTC/572-671---------..------..SSGAG...........KINCLI--------APR------------------ILRTEK----
M3JFE1_CANMX/645-744---------.L------SEFTNNQ...........TVNTLI--------APK------------------ILRTAK----
Q6BZF3_DEBHA/634-743---------.L------SDYSTKQ...........GINTLI--------APR------------------ILRTAK----
A3LN41_PICST/588-699---------.L------ADISPKY...........PINTLI--------APK------------------ILRTEK----
G3AMT0_SPAPN/577-678---------.I------SDLSTQP.............NTLI--------APK------------------ILRTEK----
C5M5V1_CANTT/627-732---------.I------TDFNTKY...........EPNTLI--------APR------------------ILRTEK----
B9WAI6_CANDC/655-759---------.V------NDVDKSS...........LLNTVI--------APK------------------ILRTEK----
Q5ALY1_CANAL/652-759---------.V------NDIDNNT...........SLNTLI--------APK------------------ILRTEK----
A5DUV3_LODEL/733-836---------.V------SDLTRTK............PNTLI--------APK------------------ILRTEK----
H8WXP5_CANO9/622-725---------.I------TDLSKHT............PNTLI--------APK------------------ILRTEK----
Q6FR08_CANGA/839-962---------QH------DNVDQHIFEEQRGQRGHNRINTIF--------APK------------------RLRTVK----
I2K400_DEKBR/545-655---------.L------KTLRKDV.............NCII--------APT------------------VLRTEK----
K0KF71_WICCF/641-748---------.H------KEFKNNI.............NAII--------APK------------------FMRTEK----
Q6FL29_CANGA/598-706---------.R------DTLSDDI.............NTIV--------APR------------------RVKTEK----
J7S1V3_KAZNA/537-650---------.H------DDVATAT........PHRQLNCII--------APK------------------RLRTVK----
H2AQS3_KAZAF/756-868---------.F------SNIDDTH...........NLNAII--------APK------------------RLRTIK----
I2H240_TETBL/888-996---------.Y------QSTKTKS............LDTII--------SPK------------------FVRTAK----
G8BNV8_TETPH/805-917---------.Y------DKIDNSY...........NLNTII--------APK------------------RMRTAK----
C5DDJ9_LACTC/677-784---------.L------KAVDVQC.............NTII--------APK------------------KMRTAK----
A7TEV9_VANPO/803-912---------.Y------NEVDEMY...........QLNTII--------APK------------------KLRTVK----
G0W872_NAUDC/775-885---------.Y------PEITSDI...........NFNTVI--------APK------------------KMRTAK----
J7R641_KAZNA/728-836---------VK------HENEHVR...........HLNCIV--------APK------------------VMRTAK----
G0VDU3_NAUCC/653-763---------.L------DEIEVGN.......G...HMNCII--------APK------------------KMRTAK----
H2AVG7_KAZAF/692-804---------.Y------GNITPNE.......SSLYHLNTII--------APR------------------KLRTEK----
C8Z9V1_YEAS8/820-932---------.F------DNIKETD...........KLNCIF--------APK------------------ILRTEK----
Q6CN34_KLULA/656-761---------.T------PEIESFT.............NTII--------APK------------------KARTAK----
M9N343_ASHG1/635-742---------.Q------EEIEEDT.............NCII--------GPK------------------KARTAK----
G8JP23_ERECY/643-750---------.H------QDIKQDS.............NCII--------APK------------------KARTAK----
G8ZYK9_TORDC/770-884---------.H------EDITTLN.......LK..KLNTVI--------APK------------------MMRTSK----
C5DS98_ZYGRC/912-1023---------.H------NEITSEN.......VG..KLDGII--------APK------------------KLRTAK----
I2GZK5_TETBL/782-893---------.H------DDITSDN.......ID..KLNTIF--------APK------------------KMRTAK----
G0VGC1_NAUCC/666-782---------.Y------DDIDTVG............LNTIV--------APK------------------QMRTVK----
G8BX11_TETPH/765-877---------.Y------DEIENDN.......YN..HLNTII--------APK------------------RMRTAK----
M7PGB1_PNEMU/569-665---------..------..VQDAK...........DCTHLV--------TSR------------------IQRTQK----
G0S8X0_CHATD/601-703---------..------..VQDTV...........PFTHLA--------APS------------------MIRTQK----
G2QQU9_THITE/602-704---------..------..VQENA...........PFDYLA--------APG------------------MIRTMK----
G9MPP7_HYPVG/606-708---------..------..VQEGQ...........PCDYLA--------APH------------------VVRTVK----
N4VGU8_COLOR/580-682---------..------..VQDDK...........ACDYLA--------APH------------------MVRTVK----

PF12738

MCPH1_HUMAN/9-75---------WDKAQKRG.VKL---------------VSVLW----------------------------------
ECT2_MOUSE/179-242---------FRVAVSLG.TPI---------------MKPEW----------------------------------
A2R3M9_ASPNC/121-184---------YKFATQWG.IRI---------------VTVKW----------------------------------
A7F1C2_SCLS1/119-182---------YKAAKSWG.LRI---------------VSAEW----------------------------------
A7S5M3_NEMVE/449-511---------YKKAREWG.IPC---------------INAKW----------------------------------
A9RB53_PHYPA/468-530---------YENAERLG.IRC---------------VTANW----------------------------------
B0DMV8_LACBS/502-564---------FDKAQEWG.IPV---------------VSIGW----------------------------------
B2VU23_PYRTR/350-412---------CEAAVEWG.VNI---------------VNHLW----------------------------------
B2W796_PYRTR/229-291---------WEKAVENN.IPV---------------VVPDW----------------------------------
B2W7P6_PYRTR/114-177---------YEHALNWG.MKI---------------VALEW----------------------------------
B3RL44_TRIAD/702-764---------FFKAKEWR.IFT---------------VNCKW----------------------------------
B4H593_DROPE/186-250---------YKKAVEWK.IPV---------------VSVLW----------------------------------
B4KSD3_DROMO/76-140---------YKRAQSWN.IPI---------------VSILW----------------------------------
B6HL54_PENCW/128-191---------YKFATQWN.IKV---------------VSVKW----------------------------------
B6Q6C3_PENMQ/111-174---------YKFATQWS.IKV---------------VSAKW----------------------------------
C0NFA4_AJECG/121-184---------YKYATLWK.ITV---------------VSLKW----------------------------------
C1FFW2_MICSR/561-624---------YEAAVGWG.LHA---------------VTVEW----------------------------------
C1GTX0_PARBA/624-691---------VREATRYPNVRI---------------VTVQW----------------------------------
C4M4C9_ENTHI/17-80---------ARHAKRWG.VPV---------------LNHQW----------------------------------
C5FMN4_ARTOC/111-174---------YKFAILWG.VKV---------------VSLKW----------------------------------
RAD4_SCHPO/105-167---------YEYALKWK.INV---------------VCVEW----------------------------------
Q014F9_OSTTA/116-179---------YVQAVTRGRVAV---------------VNHLW----------------------------------
Q16W28_AEDAE/219-283---------YQKAKKMN.VPV---------------VSILW----------------------------------
Q1K5Z2_NEUCR/339-401---------CEAAKEWN.IEI---------------INHLW----------------------------------
Q2H787_CHAGB/324-387---------YHAAKNWG.VTT---------------VSVEW----------------------------------
Q4CP92_TRYCC/1-63---------CRVARERG.IPC---------------VTPAW----------------------------------
Q4PHX3_USTMA/599-667---------AQHARSCG.VPV---------------VGLDF----------------------------------
Q5TRD6_ANOGA/110-173---------YRYAMTFR.LAI---------------IRPNW----------------------------------
Q6CN34_KLULA/351-414---------FEAARAWACCTA---------------ANHLW----------------------------------
PAXI1_MOUSE/102-165---------YERAVKRTSIKI---------------VTPDW----------------------------------
Q6Z553_ORYSJ/10-72---------YDIARRLR.TRV---------------VSHRW----------------------------------
Q9U7D8_DROME/117-180---------YQYAKTFR.LTV---------------VRPAW----------------------------------
B9GSH3_POPTR/111-175---------YELANKMKKMKL---------------VNHRW----------------------------------
D7SMI0_VITVI/4-66---------YSLAKKFK.TLI---------------VNHRW----------------------------------
F4I701_ARATH/188-251---------YKVARKWGHIQI---------------VTRKW----------------------------------
F4I701_ARATH/667-729---------YVRASKWG.IIS---------------VTPDW----------------------------------
F6XFW7_XENTR/204-267---------YECARKWN.VHC---------------VSVQW----------------------------------
H0ZRM8_TAEGU/5-67---------WKKAQKMG.VKL---------------VSVLW----------------------------------
H3C8W0_TETNG/80-141---------YEKAKEWK.IPC---------------VNAQW----------------------------------
I1QYC0_ORYGL/209-271---------YVVAQKWGNIHI---------------VVPKW----------------------------------
I1QYC0_ORYGL/675-736---------YEAYYSRG.IPT---------------ITAEW----------------------------------
Q4WQC2_ASPFU/345-407---------CAAAKEWG.LHV---------------VNHLW----------------------------------
Q7JUM5_DROME/187-251---------YKKATEWN.IPV---------------VSILW----------------------------------
U5GIH0_POPTR/4-66---------YELASKFD.TLV---------------VNHRW----------------------------------

PF00533

Y4211_ARATH/1089-1168.........FFAAAASG-SWI---------------LKTDYVADSK-----------------------------
MDB1_SCHPO/384-455.........FLLATSLG-IPL---------------VSSQYLTDCI-----------------------------
MDB1_SCHPO/485-573.........ATGLNVYK-IEL---------------VALSILRDRI-----------------------------
ECT2_MOUSE/266-341.........LPFEPSKK-LFV---------------VKQEWFWGSI-----------------------------
PAXI1_HUMAN/701-776.........YEKAKEWR-IPC---------------VNAQWLGDIL-----------------------------
PAXI1_HUMAN/860-934.........FLTAISVV-KHI---------------VTPEWLEECF-----------------------------
TDT_HUMAN/27-111.........QKVQVSSQ-PEL---------------LDVSWLIECI-----------------------------
RAD9_YEAST/994-1109.........YLETLALG-WPT---------------LHWKFISACI-----------------------------
XRCC1_HUMAN/538-616.........EALMDNPS-LAF---------------VRPRWIYSCN-----------------------------
Q93161_CAEEL/981-1063.........LLLWVFNG-AII---------------VKEQWMVDCL-----------------------------
PARP4_HUMAN/1-81.........LNSIQKNH-VHI---------------ANPDFIWKSI-----------------------------
TOPB1_HUMAN/101-176.........YLVAANLK-KPI---------------LLPSWIKTLW-----------------------------
TOPB1_HUMAN/195-271.........YECAKRWN-VHC---------------VTTQWFFDSI-----------------------------
TOPB1_HUMAN/354-431.........FWNKSAHR-PHV---------------VGAKWLLECF-----------------------------
TOPB1_HUMAN/548-620.........GCEVEATV-GEV---------------VTNTWLVTCI-----------------------------
TOPB1_HUMAN/641-725.........YEAAKKWN-LPA---------------VTIAWLLETA-----------------------------
TOPB1_HUMAN/900-978.........YKSVKERG-VHI---------------VSEHWLLDCA-----------------------------
TOPB1_HUMAN/1260-1338.........YLASVAAG-KWV---------------LHRSYLEACR-----------------------------
Q20129_CAEEL/451-529.........RKHLHQED-IAI---------------VTVGWVVECV-----------------------------
Q20129_CAEEL/587-659.........PMHELISF-DAV---------------VTDFYIYASI-----------------------------
Q20129_CAEEL/679-749..........DNPPRYH-SRT---------------LDFSWIIASV-----------------------------
DNLJ_HAEIN/592-668.........LAKAQELN-ITV---------------LTEEEFLAQI-----------------------------
DNLI4_CANAL/673-756.........SSQYLSKG-IDL---------------VKPIWIYECI-----------------------------
Q20129_CAEEL/128-204.........YKAAVNNS-IKL---------------MRIGWIDDLW-----------------------------
O76369_CAEEL/929-1023.........IFFWIFNG-TII---------------VKEQWMSDCL-----------------------------
PAXI1_MOUSE/94-170.........ERAVKRTS-IKI---------------VTPDWVLDCV-----------------------------
PAXI1_MOUSE/588-668.........YTQALRER-KRC---------------VTAHWLNTVL-----------------------------
PARP1_MOUSE/385-463.........MEEVKEAN-IRV---------------VSEDFLQDVS-----------------------------
DNLI4_HUMAN/654-730.........KNIILSNK-HDV---------------VKPAWLLECF-----------------------------
DNLI4_HUMAN/814-898.........FRRTFKRK-FKI---------------LKESWVTDSI-----------------------------
O16568_CAEEL/1044-1144.........KWQSMHAM-YTL---------------VDFSFLAECI-----------------------------
TDT_MONDO/27-111.........HKMEKTTQ-FEL---------------LDISWLIECM-----------------------------
O16229_CAEEL/378-460.........LLVWIFNG-AII---------------VKEKWMTDCL-----------------------------
DNLJ_HELPY/577-652.........LALAQKHG-VSV---------------LNEEELLKRL-----------------------------
DNLJ_BACSU/590-666.........LTKAQELN-IEV---------------WNEEQLMGEL-----------------------------
DNLJ_MYCLE/607-683.........YDKAVELG-VPI---------------LNEDGFRLLL-----------------------------
O44844_CAEEL/154-256.........KWTFANNC-ISF---------------LGMGWLVECI-----------------------------
DNLJ_BORBU/583-659.........LKKALSLN-IKI---------------MSFEDIKSYL-----------------------------
BRCA1_RAT/1588-1669.........YFLGIAGG-KWI---------------VSYSWVIKSI-----------------------------
BRCA1_RAT/1701-1787.........PDIGQLCK-GRL---------------VMWDWVLDSI-----------------------------
RFC1_SCHPO/236-313.........VETIKQHK-IPA---------------INEDGLFYLI-----------------------------
DNLJ_AQUAE/619-696.........LSKAKKYG-VKT---------------ITEEEFVNMI-----------------------------
CHS5_CANAL/164-246.........YVKANDMN-IPI---------------IRPEWLKACE-----------------------------
DNLJ_TREPA/562-642.........LKKEQGVA-LEI---------------ISEDEFCRLL-----------------------------
DNLJ_CHLTR/581-657.........LKKAQDLG-LSI---------------WNESELLRIL-----------------------------
O96271_PLAF7/208-298GRKYTKAFELQQQNKSN-IKI---------------LNEEELLKLL-----------------------------
PESC_LEIMA/317-390.........PGMKKHDQ-LEY---------------VQPQYIFDCL-----------------------------
DNLJ_ECOLI/593-669.........LAKAQELG-IEV---------------IDEAEMLRLL-----------------------------
PARP1_CHICK/382-460.........MEEVKDAK-VRV---------------VSEEFLKDVK-----------------------------
DNLJ_THET8/589-664.........LEKARALG-VPT---------------LTEEELYRLL-----------------------------
DNLJ_ZYMMO/645-721.........LSKAKELD-ISI---------------IDEDRWHRIV-----------------------------
RAD4_SCHPO/2-79.........FAAKSRPD-IKI---------------MSSEWIPVLY-----------------------------
RAD4_SCHPO/97-172.........YEYALKWK-INV---------------VCVEWLWQSI-----------------------------
RAD4_SCHPO/392-473.........IQHATEWN-VRV---------------VGVAWLWNII-----------------------------
RFC1_DROME/232-309.........LAVAEELN-IPI---------------LSEDGLFDLI-----------------------------
TDT_CHICK/27-111.........QAVGDSSR-FEI---------------LDISWLTACM-----------------------------
BRCA1_HUMAN/1642-1723.........YFLGIAGG-KWV---------------VSYFWVTQSI-----------------------------
BRCA1_HUMAN/1756-1842.........HAIGQMCE-APV---------------VTREWVLDSV-----------------------------
RFC1_YEAST/153-230.........LEKIKQLK-IKA---------------IDEEGFKQLI-----------------------------
RT107_YEAST/2-103.........KIVYFDLL-IPV---------------VSHTWVQDSV-----------------------------
RT107_YEAST/117-213.........HTEKPLRE-WKF---------------VYPIWILYHF-----------------------------
RT107_YEAST/261-352.........KTKSIKPE-IHV---------------GNVSWLFYMF-----------------------------
RT107_YEAST/370-453.........WSLDPQNA-IIV---------------TNHMWLEQCY-----------------------------
YPT4_CAEEL/930-1012.........LLIWIFHG-SII---------------VRDTWMVDCL-----------------------------
YPT4_CAEEL/1049-1141.........YRSDPDKM-FTL---------------FTEQQFMDLL-----------------------------
DPB11_YEAST/111-207.........VNAAIEQN-IPI---------------VHFKWILDCQ-----------------------------
DNLJ_SYNY3/591-667.........AAKAESLG-IKL---------------LSEAEFLQLL-----------------------------
RHP9_SCHPO/535-640.........YLEALAFN-IPC---------------VHPQFIKQCL-----------------------------
FCP1_YEAST/499-580.........LAKKFNPQ-IKI---------------VHPDWIFECL-----------------------------
DNLI4_YEAST/681-767.........CKALIDRG-YDI---------------LHPNWVLDCI-----------------------------
DNLI4_YEAST/836-928.........ASDTIPKI-ARV---------------VAPEWVDHSI-----------------------------
Q09615_CAEEL/251-326.........KINRIREN-EIF---------------IKADWITESI-----------------------------
BRC1_SCHPO/14-91.........VQEGSKRS-LRL---------------AKTNWIRDCV-----------------------------
BRC1_SCHPO/105-183.........VLDKPSLS-IKL---------------IHPQWLLDCL-----------------------------
BRC1_SCHPO/216-293.........FNLASNKN-TTI---------------GTISWLLNLF-----------------------------
BRC1_SCHPO/311-386.........YGAAKVWN-IPT---------------VHHSWLYSSF-----------------------------
CHS5_YEAST/166-249.........LIRAKHNN-IPI---------------VRPEWVRACE-----------------------------
Q18104_CAEEL/407-489.........LLIWILNG-IIF---------------VKESWMTDCL-----------------------------
XRCC1_MOUSE/315-390.........YSQVLGLG-GRI---------------VRKEWVLDCH-----------------------------
Q94046_CAEEL/514-600.........VMTSLEHR-KRI---------------VSIQWIIDVM-----------------------------
Q94046_CAEEL/620-694.........VTRAQEWK-VPV---------------VNFQWIADAY-----------------------------
DNLJ1_STRCO/643-719.........YDKAMQLK-VPV---------------LNEDGFAVLL-----------------------------
DNLJ_RICPR/610-686.........LKKAKELN-IKI---------------IDEVEWLAFI-----------------------------
PARP1_ARATH/394-471.........MRKARRMK-VAI---------------VREDYLVDCF-----------------------------
D0MI04_RHOM4/636-709.........YDRARQLG-IPM---------------LDEDGLLRLL-----------------------------
H9KXM3_CALJA/403-478.........SDKAAALG-TKI---------------IDEDGLLNLI-----------------------------
Q5AZH7_EMENI/325-400.........LATISKHK-LKT---------------ISEEGLFELI-----------------------------

PF16759

H2ZXR2_LATCH/884-956---------...EGNSN-AKR---------------VSPNWIWECVKKRRV------------------------
F6S783_MACMU/933-1005---------...DKNPA-AQQ---------------VSPEWIWACIRKRRL------------------------
D2W3T0_NAEGR/824-906---------KLVSENPQ-VNV---------------VSSEWIWHSINTSTL------------------------
H3CY38_TETNG/809-881---------...EDDSG-AQR---------------VTPSWIWECIRKRRV------------------------
G3QCE5_GASAC/909-981---------...EDDSQ-AER---------------VSPDWIWECIRKRRI------------------------
Q1RL58_CIOIN/781-858---------KVADIPIS-ASL---------------VTASHVWECIKNKVS------------------------
E0VGK6_PEDHC/807-896---------NEKYWDKG-VRH---------------VHVNWIWNSIKLLDK------------------------
H0Z3J4_TAEGU/853-925---------...AGSPG-AQR---------------VTARWIWECIRKRRL------------------------
H2MK50_ORYLA/283-355---------...GEDSR-AQR---------------VSPSWIWECIRKRRV------------------------
C3XPG8_BRAFL/848-925---------KNMNGKTD-AQL---------------VTVDWLWQCIKRKQL------------------------
D6WBL1_TRICA/353-434---------PTIHCANS-AKH---------------VIVEWIKDTVAEENL------------------------
F2US92_SALR5/1151-1238---------VSMASSTG-ARV---------------VTAKWLWDSIKRRTR------------------------
D6WBL2_TRICA/760-840---------EIDQCNPD-VKH---------------VTVDWIKNCVVNESV------------------------
H2Z1K6_CIOSA/772-849---------KRLDISSE-ALS---------------VTSKYVWECIQNENT------------------------
E9CDE4_CAPO3/1228-1306---------ASDRDNGN-APA---------------VLPSWIDACIAAG..------------------------
F6WXI9_XENTR/905-977---------...ECIAD-AKH---------------VTPHWIWECIRRRR.------------------------
J9JUI3_ACYPI/779-867---------KEKKKSLN-ATA---------------VCAQWFWDSIRKGT.------------------------

PF16589

RAP1_SCHPO/1-104---------DERVSDLD-IPKGFFERNPEFRH..KMLKIAWITQCIEQGKL-----------------LPTESFE
M5FSC1_DACSP/182-279---------FSDKAQVK-SAELGWKHGRTV......IKPTWIEACVAAHDL-----------------VPIDDFV
H3C9A2_TETNG/9-93---------DASSLSPN-RLRSIRKHQTPV......VGVEYVSSCLERGAL-----------------LPLDGYR
Q08CM6_DANRE/45-136---------HVNDLSSN-RQRSIQKLQIPV......VGTQYVWSCVDEGHL-----------------LPLTEHN
R4XAV8_TAPDE/3-87---------AKPQSYDA-S..........W......LNFRYIDDALREGQL-----------------QNPEYYV
C4V7R6_NOSCE/195-261---------SKEYENTK-HKL...............LHYQYIFDCVEYKAE-----------------LFPNSYF
M2Y325_GALSU/16-125---------EQVIVLLD-TNTKLSRASKMTAKLTECFSLSYIESCIEQNKL-----------------LNLNDFR
B7QFB5_IXOSC/8-93---------GATVSVND-RDP........V......FSTEFVRECSKRDLL-----------------LPLRNFA
A3LW54_PICST/41-121---------NPLTGRRS-..................YRVQYIDDCVRLVTL-----------------QDIRIYS
D3BEV4_POLPA/10-104---------YKIKGATK-LCD...EGELRL......VSTQYITDCVEANRL-----------------LSDDRYQ
J4I894_FIBRA/337-429---------KPFSDWLR-RAQ...QAKRPT......AQASYVHDCITEGSI-----------------LDIEPYS
F0WYP1_9STRA/24-103---------SELKPEKN-...........W......VSTDFIYDSIKAKQL-----------------KPIDLYQ
C5M515_CANTT/70-152---------AISLGQHG-V.................FSIDFIDDCIEQGQI-----------------IAIAPYI
A5DYD1_LODEL/66-146---------TKDMGGY.-..................VRTQFIDDCILAGTL-----------------LPSHNYV
G8BJX2_CANPC/111-190---------SHLGGF..-..................VRIDYIDDCVSVGQL-----------------LPFEGYT
H8X494_CANO9/94-173---------EHLGGF..-..................VRINYIDDCIGMGQL-----------------LPPGDYT
G3AM46_SPAPN/45-124---------AEEGHG..-..................IQLRFIDECINQGRL-----------------VNLDSFR
M3K224_CANMX/72-151---------EKMLGY..-..................FKLKFIDDCIANGGL-----------------VPLLDYG
C4YKS1_CANAW/89-168---------EDLYGF..-..................SKLKFIDDCIAKNQL-----------------LSVFDYG
B9WCR9_CANDC/86-165---------EELIGF..-..................IKLTFIDDCIAQNQL-----------------LPVIDYG
G1XSA5_ARTOA/13-91---------LKSQGNVQ-KA................VSYKWIVACVENREL-----------------VDTENFF
E6R8V2_CRYGW/313-411---------DHIEAVRS-VRG...QEWRVV......VSEEWILDCVEKGKL-----------------LDVKGYL
F1KRF2_ASCSU/907-985---------HYRTHKYL-SAL...ARSVPC......VRHQWIRDCVEQNKL-----------------LDYNDYM
B3RX95_TRIAD/6-86---------DTLTPLGY-..................VSASFIFDSVANNAL-----------------QDIESYM
A7RVV1_NEMVE/15-100---------SKDKPLLD-G..........Y......TSSEYIKDCIHKNEL-----------------LNIKPYQ
H2KSC7_CLOSI/10-91---------GSLVGSDR-Y.................IHVQYVRDCIRARRR-----------------LPMDGYK
G5C0W9_HETGA/11-94---------GEVLAETS-GDF...............ISTRYILDCVERKER-----------------LELEDYW
F1R0Q3_DANRE/33-119---------TDATNVTQ-......NTGQKY......ISTKYILDCVEQNQQ-----------------LDPNDYA
H3AZ33_LATCH/22-105---------EESEGGWS-PEH...............ISVRYITDCVSRNER-----------------LDLEAYR
H3DBF1_TETNG/17-103---------VEGAAIPA-......STTHWY......VSTRFIQDCVEKNEQ-----------------LDLELYR
H2URR3_TAKRU/14-100---------AAGSSIPE-......NATHWY......VSTQYILDCIKNNEQ-----------------LDVESYR
M4ASB2_XIPMA/13-99---------EENSSVLE-......SDAHRY......VSTQYIHDCIKKEEQ-----------------LDLDDYR
I3KA69_ORENI/14-100---------EDRSVIPE-......STAHWY......VSTQYIYDCVEKNEQ-----------------LNLEDYR
G3NA35_GASAC/14-100---------EERGSISE-......STTHWF......VSTQYIFDCIEKNEQ-----------------LNLEDYK
J8ZTC5_EDHAE/363-439---------SPEYLDLA-KKY...............VQPQFIYDCFNKRDL-----------------LDYRQYS
M7PBU4_PNEMU/1-86---------LKDYKTPD-I.................VSYYFILDSINLGKL-----------------LNIKEYY
F6WHH4_CIOIN/18-102---------NTDTYKTQ-RAL...KLGIPV......VSSSYIDACIHDNTL-----------------LDTDDYA
J7S744_KAZNA/61-148---------YNYTNRIT-..................VTPTYLKACAKSNTL-----------------LSYNRYI
I2GXL7_TETBL/69-154---------YNNTGIST-..................LSPTYIKECINANTL-----------------LEKDQYL
C5DD36_LACTC/53-131---------INASDLPT-..................VTPTYIKTCCENNVL-----------------MKVQPFL
G0WD26_NAUDC/165-250---------YNDTKLPT-..................ITTTYIRTCIARDTL-----------------LPLENYL
G8ZLB0_TORDC/16-100---------YNDTRLPT-..................VTPAYIKACCENGTL-----------------LKIENYL
F2Z6A0_CANGA/80-168---------YNNTELKT-..................VTSTFIRACVQSNKL-----------------LDMKNYL
G0VI01_NAUCC/119-206---------YNDTKLPT-..................VTPTYIKACVSNNTL-----------------LNINHYL
H2APC0_KAZAF/72-157---------YNDTNLPT-..................VTPTYIKACVQSKKR-----------------LDIGNYL
C5DTR6_ZYGRC/67-154---------YNDTRLPT-..................VNPTYIRACCQNGTL-----------------LDIGNYL
A7TIC7_VANPO/66-154---------YNDTKLRT-..................VTSTFIKACCQNNTL-----------------LNIDNYL
G8C1X2_TETPH/45-136---------YNSTNLNT-..................VTATYIKACCQNNTL-----------------LEAHDYL
D8Q0I4_SCHCM/674-767---------STPYDLQL-IIR...KDTNDV......VRPQWVMDCIAKGEL-----------------VPMEKKY
J6EKB0_SACK1/356-448---------ALKNKVAG-RTY...............IQPQWIFDCINKGEL-----------------VPANKYL
B0EKW8_ENTDS/154-233---------GEHKNIER-EF................IQPQWIFDCVNENFI-----------------LPCGEYA
L2GQH2_VITCO/272-348---------VDAIDPEN-IY................LQPQYVFDCLNQSKI-----------------LPYDLYF
A7ATP9_BABBO/280-357---------ITELDIKK-D..........Y......VQPQYVFDCLNCGIL-----------------LPVQQYA

PF16770

F2QSE6_PICP7/699-801---------FLITLSKSP.NLL--------------LHESFLLSVLQAKQEQDLP.............ELEEYSI
A5DNV2_PICGU/524-631---------FLTSLS..QADKI--------------IHPQYLIDLLKVVNESSTWES...........INKQFKM
G8YM20_PICSO/621-729---------FLKALS..KAKRI--------------VHPNFLTDILQAKKNFTDYESI..........LLNEFPI
G3AYG3_CANTC/572-671---------FLSSLG..KVDFI--------------LHPRLLIDLKYLLGRG................ESPEIEI
M3JFE1_CANMX/645-744---------FLRCLS..TVDNI--------------IHPQYLVDILKAE...................KVEDIKI
Q6BZF3_DEBHA/634-743---------FLRSLS..QVDKI--------------IHPNYLIDVLKKLNSSQDADGDQ.........VSKEFSI
A3LN41_PICST/588-699---------FLRSLS..QVKEI--------------IHPNYLIEILKKLNTTEGESIDETA.......VFKEFSI
G3AMT0_SPAPN/577-678---------FLRSLA..KVDHI--------------VHPKYLIDVLKNVDKQT...............VLTEFNI
C5M5V1_CANTT/627-732---------FLRSLS..KVDRI--------------IHPNYLINILEHVKDKGKS.............VLKEYRI
B9WAI6_CANDC/655-759---------FLRSLS..KVDKI--------------IHPDYLVNVINHISKGEN..............VLKEYRI
Q5ALY1_CANAL/652-759---------FLRSLS..KVDKI--------------IHPNYLVNIINHISSKGDTET...........VFKEYRI
A5DUV3_LODEL/733-836---------FLRSLS..TVDKI--------------IHPSFIVDVLANIENTDN..............VRLRYNV
H8WXP5_CANO9/622-725---------FLRSLS..KVCRI--------------VHPSYIVNVLANAENNGD..............TLSLYRI
Q6FR08_CANGA/839-962---------FLKSLSLSSIRYF--------------LTPDYITALLLDIKSGKDVSKYRS........PSNSFRI
I2K400_DEKBR/545-655---------FLKALSMSP.KYI--------------ISPLFVSDVLGTLDICHRITDFDAV.....KPDINVYQL
K0KF71_WICCF/641-748---------FLTGLSY.QLDYI--------------LSPTFLQEVLIKFKNDPNDVNSLP........DISNFSI
Q6FL29_CANGA/598-706---------FLKALALPTLAHV--------------ITPGFVERVLKLHKAEKLHEAPQL........KLGQYQL
J7S1V3_KAZNA/537-650---------FLTSLSFHPLQYA--------------LVPQFVEDLLALNEKPPIDEYPDA........GDPQYRI
H2AQS3_KAZAF/756-868---------FLKSLSFNSLDYA--------------ITPGFINEILKSVYNTKNTTFDTLK.....I.AHDKYAI
I2H240_TETBL/888-996---------FLTSLSFHPLKHA--------------INPEFIKDILNVISQGKQVNYIL.........NLEKYRL
G8BNV8_TETPH/805-917---------FLKSYSFQPLLFL--------------LLPKFITDILSVLHTKTDSERTDIE.....L.DPKMYSI
C5DDJ9_LACTC/677-784---------FLTSFGFHPLKWA--------------LMPEFVSELLSIFRQTTPIQELP.........KPEDYLI
A7TEV9_VANPO/803-912---------FLKSLSFTPLQNA--------------LLPDFVMAILDRIHHRKPASIEF.........DLSQFTI
G0W872_NAUDC/775-885---------FLKSFSFHPLKNI--------------LLSTFIDDILKNIHIGNNDFFQGI........TLNDYKL
J7R641_KAZNA/728-836---------FLISLSFKPLKYV--------------LLPQFISDVLNAVSRGASFPL...........DFERYVI
G0VDU3_NAUCC/653-763---------FLMSLSFHPLKYA--------------LLPDFITDVLKFVHRGESPMELM.........NLDDYRI
H2AVG7_KAZAF/692-804---------FLRSLAFHPLKFA--------------LLPEFVTDLLEKLHNRENPSEL..........NIKQYFI
C8Z9V1_YEAS8/820-932---------FLKSLSFEPLKFA--------------LKPEFIIDLLKQIHSKKDKLSQINI.......NLFDYEI
Q6CN34_KLULA/656-761---------FLKSFSFKPLKYA--------------LTPMFITNILTNINKEKPVEL...........EMSKYFI
M9N343_ASHG1/635-742---------FLTSFSFHPLKYA--------------LLPKFITEILSLVHSGRNEPISL.........PLEQYYI
G8JP23_ERECY/643-750---------FLKSFSFRPLKYA--------------LIPKFINDVLSIVHSGSGASVLL.........SLEEYHI
G8ZYK9_TORDC/770-884---------FLKSFSFHPLKYA--------------LRPDFLTDLLSLIHSGQVTTRQDML.....L.DLSNYTI
C5DS98_ZYGRC/912-1023---------FLKSLSFHPLRYA--------------LTPKFLKDILRIIHKGKKANLSL.........DISRYYI
I2GZK5_TETBL/782-893---------FLKSFSFKPLKYL--------------LTPSFLIDLLAIINGKKSGSIKL.........PFEKYQI
G0VGC1_NAUCC/666-782---------YLKSLSFEPLKYA--------------LIPEFIMDQLRVIREARGQNKRKLRREEIML.DLTKYTI
G8BX11_TETPH/765-877---------YLKALSFRPLKYA--------------LMPDFITLILKEIHSGKIDLNLKV........DLTKYYI
M7PGB1_PNEMU/569-665---------FLSALSYAP..KI--------------LSVDWIKACLKERKIM................DENNYFL
G0S8X0_CHATD/601-703---------FLVALAKGP..DV--------------ISSDFVTACIEKGKRP................NVDDYRL
G2QQU9_THITE/602-704---------FLRCLAKGP..DV--------------IDSSFITACIETGKRP................NIKDHLL
G9MPP7_HYPVG/606-708---------FLCALARGP..TV--------------ISSTFIEKTLETGKLQ................DVDDFIL
N4VGU8_COLOR/580-682---------FLRTLAKGP..TI--------------LSSTFIDAALDKGEKP................DPEDYLL

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (C,A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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