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775  structures 5538  species 0  interactions 540417  sequences 16318  architectures

Clan: Ank (CL0465)


Ankyrin repeat superfamily Add an annotation

The ankyrin repeat is a short sequence region that is about 30-34 amino-acids in length. Multiple copies of the repeat composed of two beta strands and two alpha helices combine to form long arrays. In general these repeats are involved in protein-protein interactions. This superfamily also includes some families that are arrays of several repeats.

This clan contains 8 families and the total number of domains in the clan is 540417. The clan was built by A Bateman.

Literature references

  1. Sedgwick SG, Smerdon SJ;, Trends Biochem Sci. 1999;24:311-316.: The ankyrin repeat: a diversity of interactions on a common structural framework. PUBMED:10431175 EPMC:10431175
  2. Mosavi LK, Cammett TJ, Desrosiers DC, Peng ZY;, Protein Sci. 2004;13:1435-1448.: The ankyrin repeat as molecular architecture for protein recognition. PUBMED:15152081 EPMC:15152081
  3. Li J, Mahajan A, Tsai MD;, Biochemistry. 2006;45:15168-15178.: Ankyrin repeat: a unique motif mediating protein-protein interactions. PUBMED:17176038 EPMC:17176038


This clan contains the following 8 member families:

Ank Ank_2 Ank_3 Ank_4 Ank_5 AnkUBD DUF3420 DUF3447

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Ank_2 (PF12796) 451226 (83.5%) View
Ank_4 (PF13637) 39003 (7.2%) View
Ank (PF00023) 23676 (4.4%) View
Ank_5 (PF13857) 19242 (3.6%) View
Ank_3 (PF13606) 4587 (0.8%) View
DUF3447 (PF11929) 1336 (0.2%) View
DUF3420 (PF11900) 892 (0.2%) View
AnkUBD (PF18418) 455 (0.1%) View
Total: 8 Total: 540417 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...