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736  structures 19680  species 37  interactions 125545  sequences 1167  architectures

Clan: PDZ-like (CL0466)

Summary

PDZ domain-like peptide-binding superfamily Add an annotation

This superfamily comprises families of PDZ domains, which are peptide binding sites.

This clan contains 5 families and the total number of domains in the clan is 125545. The clan was built by P Coggill.

Members

This clan contains the following 5 member families:

GRASP55_65 PDZ PDZ_1 PDZ_2 Tricorn_PDZ

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PDZ_2 (PF13180) 74587 (59.4%) View
PDZ (PF00595) 48255 (38.4%) View
GRASP55_65 (PF04495) 1138 (0.9%) View
PDZ_1 (PF12812) 898 (0.7%) View
Tricorn_PDZ (PF14685) 667 (0.5%) View
Total: 5 Total: 125545 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 37 interactions for this clan. More...

Interacting families
A B
GRASP55_65 GRASP55_65
MAGUK_N_PEST PDZ
Metallophos PDZ
PD40 Tricorn_PDZ
PDZ Cadherin_C
DUF4136
EB1_binding
EBP50_C
Lys
MAGUK_N_PEST
NMDAR2_C
PDZ
PDZ_assoc
Peptidase_M50
Porin_1
SAM_1
SH3_2
Syndecan
Trypsin
Trypsin_2
PDZ_2 Lon_C
PDZ_2
Peptidase_S41
Trypsin_2
PDZ_assoc PDZ
Peptidase_M50 PDZ
Peptidase_M61 PDZ_2
PID PDZ
Porin_1 PDZ
Ras PDZ
SH3_2 PDZ
Tricorn_PDZ PD40
Peptidase_S41
Trypsin PDZ
PDZ_2
Trypsin_2 PDZ
PDZ_2

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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