Sequence alignment for CL0466

PF13180

C9A6A9_ENTCA/322-419----------------------------------------------------------PALGIQTID-LGSITSQQQEQI
Q7VJB0_HELHP/178-253----------------------------------------------------------GDLGIRFEN-SKA.........
A7ZFX4_CAMC1/179-256----------------------------------------------------------GDIGVKFLQ-KED.........
Q0S4Y2_RHOJR/404-487----------------------------------------------------------AVIGIQVPS-QDA.........
D1BL26_VEIPT/269-359----------------------------------------------------------PYIGVWAVD-RQTAARN.....
B1VP64_STRGG/452-541----------------------------------------------------------PVIGATVTM-EEK.........
D2R087_PIRSD/256-349----------------------------------------------------------GFLGVAPSL-LTPDER......
Q30TR4_SULDN/163-240----------------------------------------------------------GDIGIRVKD-ENS.........
A0RM44_CAMFF/175-252----------------------------------------------------------GDIGVTFSD-DNG.........
C9ZC44_STRSW/506-595----------------------------------------------------------PVIGASVSL-EEG.........
B1XQ68_SYNP2/485-563----------------------------------------------------------PYLGLTVTD-QNN.........
A9B2Z4_HERA2/473-551----------------------------------------------------------PQLGIRSKA-VDG.........
Q315Q4_DESAG/369-449----------------------------------------------------------SRMGFTLVM-AEG.........
D5SYB3_PLAL2/269-351----------------------------------------------------------GLMGISFTG-NDL.........
Q1D977_MYXXD/477-552----------------------------------------------------------GWLGVTTRG-SGT.........
C8X5D5_DESRD/676-755----------------------------------------------------------PVLGLQVRS-QDG.........
B2IZX7_NOSP7/201-295----------------------------------------------------------GYLGVGMQP-VRLPKNLKT...
B5HUE3_9ACTN/403-492----------------------------------------------------------AKIGASVSL-EDS.........
D2QHW4_SPILD/97-182----------------------------------------------------------NGIGALIGQ-RQ..........
A2TY74_9FLAO/100-182----------------------------------------------------------VGIGVQFRM-IKD.........
F3Z8A9_9ACTN/527-616----------------------------------------------------------PVIGATVSL-EEG.........
G2SPM5_LACRR/328-425----------------------------------------------------------PALGISLVD-LDYVSEADRSQT
O24877_HELPY/170-247----------------------------------------------------------GDIGVRLEE-HHK.........
Q0P7Y5_CAMJE/170-244----------------------------------------------------------GDIGVDFVV-REN.........
Q5HNH7_STAEQ/304-394----------------------------------------------------------PSIGIGLIN-LSDIPENYR...
Q79HP3_WOLSU/168-242----------------------------------------------------------.DLLIRFEK-NRR.........
Q8DMW2_STRR6/293-388----------------------------------------------------------PALGIQMVN-LSNVSTSDIR.R
Q8Y5K8_LISMO/122-196----------------------------------------------------------....QEVKV-TYD.........
Q99XG9_STRP1/301-396----------------------------------------------------------PALGISMVN-LNDLSTNALS.Q
Q9HSH6_HALSA/244-350----------------------------------------------------------AYLGVSFTP-VTPTVADA....
R5FHL8_9CLOT/166-248----------------------------------------------------------.GIGAMLSQ-NRT.........
R5KJ64_9CLOT/126-209----------------------------------------------------------AGIGVVVRQ-DED.........

PF00595

DVL1_MOUSE/251-336TVTLNME..RH-----------------------------------------------HFLGISIVG-QSN---DR....
ZO1_MOUSE/23-107TVTLHRA..PG-----------------------------------------------FGFGIAISG-GRD---NPHF..
ZO1_MOUSE/186-261KVTLVKS.RKN-----------------------------------------------EEYGLRLAS-...---......
ZO1_MOUSE/423-501KLVKFR...KG-----------------------------------------------DSVGLRLAG-GND---V.....
AFAD_HUMAN/1009-1090TVTLKK....Q-----------------------------------------------NGMGLSIVA-AKG---AGQ...
PTN3_HUMAN/510-595LIRITPD..ED-----------------------------------------------GKFGFNLKG-GVD---QK....
SP4B_BACSU/103-184DLKVIP...GG-----------------------------------------------QSIGVKLHS-VGV---LV....
CTPA_SYNP2/102-182SLKVSTS.GEL-----------------------------------------------SGVGLQINV-NPE---V.....
PDLI1_RAT/5-82QIVLQ....GP-----------------------------------------------GPWGFRLVG-GKD---FE....
APBA1_HUMAN/656-740DVFIEKQ..KG-----------------------------------------------EILGVVIVE-SGW---GS....
APBA2_MOUSE/660-733TVLIKRP.DLK-----------------------------------------------YQLGFSVQ.-...---......
DLG1_DROME/216-300DIQLER...GN-----------------------------------------------SGLGFSIAG-GTD---NPHI..
DLG1_DROME/330-418EIDLVK...GG-----------------------------------------------KGLGFSIAG-GIG---NQHI..
DLG1_DROME/506-584TITIQK...GP-----------------------------------------------QGLGFNIVG-GED---G.....
PDLI4_HUMAN/4-81SVTLR....GP-----------------------------------------------SPWGFRLVG-GRD---FS....
DSH_DROME/252-337TVSINME..AV-----------------------------------------------NFLGISIVG-QSN---RG....
EM55_TAKRU/73-151EVAFEKN..QS-----------------------------------------------EPLGVTLKL-NDK---Q.....
EM55_HUMAN/71-149LIQFEKV..TE-----------------------------------------------EPMGITLKL-NEK---Q.....
DEGQ_ECOLI/257-346QLIDFGE.IKR-----------------------------------------------GLLGIKGTE-MSA---DIAKAF
DEGQ_ECOLI/365-444SASAEMI..TP-----------------------------------------------ALEGATLSD-GQL---KD....
DEGS_ECOLI/248-336LIRDGRV..IR-----------------------------------------------GYIGIGGRE-IAP---LHAQGG
DEGS_HAEIN/242-322KIMRDGR.VIR-----------------------------------------------GYFGVQSDI-SSS---SE....
HTOA_HAEIN/268-358QQILEFGQVRR-----------------------------------------------GLLGIKGGE-LNA---DLAKAF
HTOA_HAEIN/377-455QLSSKTE..LP-----------------------------------------------ALDGATLKD-YDA---KG....
DEGPL_BARHE/289-378QQLIEKGLVQR-----------------------------------------------GWLGVQIQP-VTK---EISDSI
DEGP_ECOLI/279-368QMVEYGQ.VKR-----------------------------------------------GELGIMGTE-LNS---ELAKAM
DEGP_SALTY/386-464QSQVDS...ST-----------------------------------------------IFSGIEGAE-MSN---KG....
LIMK1_HUMAN/165-255LVSIPAS..SH-----------------------------------------------GKRGLSVSI-DPP---HGPPGC
LIMK2_CHICK/152-236LISMPAA..TD-----------------------------------------------GKRGFSVSV-EGG---CSS...
LIMK2_RAT/152-236LISMPAT..TE-----------------------------------------------CRRGFSVSV-ESA---SSN...
LIN2_CAEEL/546-624LVQFQKD..TQ-----------------------------------------------EPMGITLKV-NED---G.....
NOS1_HUMAN/17-96SVRLFKR..KV-----------------------------------------------GGLGFLVKE-RVS---K.....
PRC_HAEIN/244-328SFNESIN.LSL-----------------------------------------------EGIGTTLQS-EDD---......
DLG4_RAT/65-149EITLER...GN-----------------------------------------------SGLGFSIAG-GTD---NPHI..
DLG4_RAT/160-244EIKLIK...GP-----------------------------------------------KGLGFSIAG-GVG---NQHI..
DLG4_RAT/313-391RIVIHR...GS-----------------------------------------------TGLGFNIVG-GED---G.....
PTN4_HUMAN/516-602VLIRMKP.DEN-----------------------------------------------GRFGFNVKG-GYD---QK....
PTP1_CAEEL/616-703VTIKMRP.DRH-----------------------------------------------GRFGFNVKG-GAD---QN....
SIPA1_MOUSE/682-754ELALPRD..GQ-----------------------------------------------GRLGFEVDA-...---......
RSEP_ECOLI/203-277EPDKED...PV-----------------------------------------------SSLGIRPRG-PQI---......
PSMD9_YEAST/99-191RSHVLL...NQ-----------------------------------------------HFDNMNVKS-NQD---ARRNND
NM111_YEAST/290-375QWLLKPY.DEC-----------------------------------------------RRLGLTSER-ESE---ARAK..
YQI7_CAEEL/25-114EVIDAHG.QVT-----------------------------------------------IRVGFKIGG-GID---QDPTKA
PRC_ECOLI/238-320NTEMSL...SL-----------------------------------------------EGIGAVLQM-DDD---......

PF14685

TRIC_SULTO/556-640----------------------------------------------------------GGLGADYEY.DKE---------
TRI_THEAC/763-849----------------------------------------------------------GRIACDFKL.D..---------
Q4J6J4_SULAC/709-795----------------------------------------------------------GGLGAEFNY.D..---------
A5US97_ROSS1/783-872----------------------------------------------------------GRLGADLRY.DAE---------
D3Q8U1_STANL/765-853----------------------------------------------------------GYLGADFTV.D..---------
Q8ZXG0_PYRAE/721-807----------------------------------------------------------GGLGAEFKW.D..---------
E8WXR8_GRATM/803-890----------------------------------------------------------GLLGADYTI.V..---------
D2AWH2_STRRD/739-825----------------------------------------------------------GKLGVDWSF.E..---------
Q020G3_SOLUE/804-893----------------------------------------------------------GLLGADYEI.V..---------
B0VF46_CLOAI/747-837----------------------------------------------------------GKLGIDYRY.NAR---------
A9BIW8_PETMO/751-841----------------------------------------------------------GYLGADLIL.D..---------
B3QU45_CHLT3/747-837----------------------------------------------------------GLLGADISY.STE---------
D9QMJ3_BRESC/796-884----------------------------------------------------------GLLGADYAI.Q..---------
C6WJJ9_ACTMD/754-843----------------------------------------------------------GLLGADLERGE..---------
E4NAZ7_KITSK/757-844----------------------------------------------------------GLLGADLVR.D..---------
C7Q5E5_CATAD/793-881----------------------------------------------------------GLLGADLAP.D..---------
E4RW77_LEAB4/768-855----------------------------------------------------------GYLGIDWQA.D..---------
C1N9P1_MICPC/828-915----------------------------------------------------------GRLGCDLVW.D..---------
D2ARY8_STRRD/732-815----------------------------------------------------------GLLGADLSW.N.G---------
B5GPX5_STRC2/828-913----------------------------------------------------------GMLGADLVR.R..---------
B5HKU3_9ACTN/746-831----------------------------------------------------------GLLGANFVL.R..---------
E4NBJ1_KITSK/740-825----------------------------------------------------------GLLGANAHR.A.P---------
A6KZI1_BACV8/751-841----------------------------------------------------------GLLGAELSR.D..---------
A6LFH5_PARD8/757-847----------------------------------------------------------GLLGAEVSR.D..---------
F3Z9P9_9ACTN/761-850----------------------------------------------------------GLLGADISR.H.E---------
F3ZGH8_9ACTN/873-959----------------------------------------------------------GLLGADFTC.R..---------
TRI_SULSO/773-858----------------------------------------------------------GGLGAEFEY.DES---------
Q5LCE8_BACFN/758-848----------------------------------------------------------GLLGAEITR.D..---------
V4IJ74_9ACTN/752-841----------------------------------------------------------GLLGADLAR.D.E---------
V4J1V6_9ACTN/791-877----------------------------------------------------------GLLGANLVR.V..---------

PF04495

Q2LYW0_DROPS/69-205LTVYSSKTQTVRELTL.TP...............STSWGGQ.................GLLGVSIRFCSFE---------
Q0U7P0_PHANO/83-216LGVFSAKGQKIREVYISVP...............STN.....................PTLGISLQWSPLA---------
Q6BX19_DEBHA/130-306LDVWSAKGGIVRQVILPLDKFEPSSKDDADESELSLFNDSF.................SQVGLTLQSQHLN---------
A5DBW3_PICGU/154-329LDVWSAKGGIIRQVRLPLNKPDELKD.ETSVDSSKLFYGLF.................AEIGVVLSSQHLN---------
GORS2_MOUSE/69-205MLIYSSKTLELREASV.TP...............SNLWGGQ.................GLLGVSIRFCSFD---------
Q0IEU2_AEDAE/69-205MTVFSSKTQNIRVVNI.MP...............STTWGGQ.................GLLGVSIRFCSFE---------
Q5KDT5_CRYNJ/68-205LRVYNTKSQRVREA....................SKASGDPNA.............KPSLLGLSLRVCNPA---------
YAT2_SCHPO/80-213LEVFSLKGQITRKVNIKIN...............SDE......................KIGMVLQWASIA---------
GORS1_MOUSE/68-204LEVFNMKTMKVREVEV.VP...............SNMWGGQ.................GLLGASVRFCSFR---------
Q4UCI6_THEAN/70-205LTVYNARKKNIRDVYI.VP................QKWDGI.................GLLGLTLKFGLFS---------
Q54C46_DICDI/73-210LIVYNIKSDTTREVSI.TP...............STTWGGQ.................GLAGISIRYCSWE---------
Q2UN33_ASPOR/80-214FEIWSAKGQKTHTASIPIS...............PSN.....................PTLGVALQLAPLS---------
A7ARE9_BABBO/70-205LNVYNARQKSLRLIKI.TP................RKWDGV.................GLLGLSVRFAEFT---------
Q4Q3U9_LEIMA/103-265FTTFNLYSRTYRDVYC.VP...............SDEWGGG.................GLLGCSIEWTRAD---------
Q22G20_TETTS/89-227MVIYDILQRKIRIVKV.VP...............NKDWSNQ................QNLLGVMLRLENYL---------
Q386P4_TRYB2/73-244LTVYNLYIHNYRDVHC.VA...............SSTWGGG.................GLLGCSVEWCQAE---------
A0A0D1CDK1_USTMA/83-237LNVWNSKRQQLRQVSL.VP...............SREWSSQPSTSSINGTSSRATSQPSLLGLSLRLCNPS---------
Q2HFQ7_CHAGB/78-211LGLWSAKGQRTRALHVPVP...............ANT.....................ASLGLALQWTPVA---------
B0S774_DANRE/70-205MEVYSTKTMRMRELEV.VP...............SNMWGGQ.................GLLGASVRFCSFQ---------
E7KBH0_YEASA/142-281.SIISKESDDLDDVSLNHDER..........RPSSGEAHQF.................QALGFKVQWTPLI---------

PF12812

NM111_ASHGO/373-450AITPSRYV--------------------------------------------------EVCGATFNELSYQ---------
B8MUN1_TALSN/264-341AITPDRFV--------------------------------------------------SVAGATFHDLSYQ---------
NM111_PICST/379-456SITPDRYV--------------------------------------------------DVGGASFNNLSYQ---------
NM111_PICGU/388-465SITPSRYV--------------------------------------------------DIAGASFNDLSYQ---------
NM111_LODEL/379-456AITPDRFV--------------------------------------------------HVAGASFNNLSYQ---------
C5MEA8_CANTT/370-447DITPNRFV--------------------------------------------------SVAGATFNDMSYQ---------
NM111_CANGA/374-451AITPSKYV--------------------------------------------------EVCGATFNELSYQ---------
NM111_KLULA/388-465IITPSRYV--------------------------------------------------EVCGANFHELSYQ---------
C4R214_PICPG/366-443AITPARYL--------------------------------------------------EVCGASFNDLSYQ---------
NM111_YARLI/360-439SITPDRYV--------------------------------------------------EVCGASFQDLSYQ---------
B6JWG1_SCHJY/372-448AIAPDRYV--------------------------------------------------EVCGATFHNLSYQ---------
B2WNT3_PYRTR/845-923DLETDRLV--------------------------------------------------SFCGATFHR.PHQ---------
C4Y709_CLAL4/134-212SMNTSRVV--------------------------------------------------FWCGALLQE.PHQ---------
NM111_KLULA/861-937ETT..RIV--------------------------------------------------VFAGCVLQA.PHH---------
Q6CHS4_YARLI/371-442ALSCTEFV--------------------------------------------------KFGGMTFHNMTYQ---------
B6QC43_PENMQ/337-413AIVPTRIL--------------------------------------------------NDSGASFHNVPYR---------
A9RQ61_PHYPA/347-422SITPNMFL--------------------------------------------------EVSGGVLHALSYQ---------
A8JH35_CHLRE/368-444TVTPNCFL--------------------------------------------------ELAGGAVHALSYQ---------
C1EGI7_MICSR/349-424DVTPSRFL--------------------------------------------------EVCGGVVHALSYQ---------
C1N456_MICPC/359-434AITPSRML--------------------------------------------------EIAGGVVNALSYQ---------
YH05_SCHPO/393-469NVTPSRFL--------------------------------------------------EVGGAVLHDLSYQ---------
B8FNF0_DESAA/337-420KIT..RFA--------------------------------------------------TFAGGTFHPLTPE---------
NM111_MAGO7/393-469SITPDRFV--------------------------------------------------SVAGGSFHSLSYQ---------
B2ASP9_PODAN/396-472KITPDRFV--------------------------------------------------SVAGGSFHELSYQ---------
B2WNT3_PYRTR/372-451AITPDKFV--------------------------------------------------SVAGASFHDLSYQ---------
C0NX23_AJECG/394-470EITPARYV--------------------------------------------------TVAGATFHDLSYQ---------
B6HPJ1_PENCW/491-567DITPDRFV--------------------------------------------------TVAGASFHDLSYQ---------
B6K3R7_SCHJY/399-475SVTPSRFL--------------------------------------------------EVGGTIFHDLSYQ---------
NM111_YEAST/392-469AITPHRYV--------------------------------------------------EVCGATFHELSYQ---------
Q5A946_CANAL/376-453SITPNRFV--------------------------------------------------VVAGASFNDLSYQ---------
Q6ZIR2_ORYSJ/179-252SITPNHFL--------------------------------------------------EVSGAVIHPLSYQ---------
Q7MWL5_PORGI/399-469.ITGESTG--------------------------------------------------NVLGASFKDLSAE---------

PF13180

C9A6A9_ENTCA/322-419LKVPSSVTSG------VVIYS........VN-NA----TPAEQAG.LQQ..............YDVITKI--DD------
Q7VJB0_HELHP/178-253.........I------.............VK-SI----DPFVPQNPFKP..............QDKILSI--NG------
A7ZFX4_CAMC1/179-256.........K------FF...........VG-LV----DPLGRGKMMMV..............DDELVTI--NG------
Q0S4Y2_RHOJR/404-487.......ANG------ATVVE........VT-AG----SPAEKAG.IPK..............GSVITKV--DD------
D1BL26_VEIPT/269-359..NVSYEGEG------LLIVQ........LD-ST----GPAAQAG.LVE..............GDTIAQI--DG------
B1VP64_STRGG/452-541.......TGG------AAISAEGAGGTPAVT-PN----GPAAKAG.LKA..............GDVITKF--ND------
D2R087_PIRSD/256-349....RAGKLG------ARIAD........VV-PA----TPAAKAG.LAM..............GDIVTHV--GE------
Q30TR4_SULDN/163-240.........V------VI...........VK-ES----NPFVESNQLKV..............GDVILEF--DT------
A0RM44_CAMFF/175-252.........T------IT...........VK-SA----NPFGAGKELLT..............GDTIVSV--NS------
C9ZC44_STRSW/506-595.......TGG------AKITNSGGGGSESIT-AN----GPADKAG.LKP..............GDVITKL--DD------
B1XQ68_SYNP2/485-563.........R------TLVQT........VN-VD----SPAHQAG.IDP..............EDELLAI--TN------
A9B2Z4_HERA2/473-551.........R------VQITH........VL-DG----GDADRAG.LAA..............GDELIAL--DG------
Q315Q4_DESAG/369-449.........R------VTVQD........VA-ED----SPARRAG.FRA..............GDVLRSA--DG------
D5SYB3_PLAL2/269-351.......SGD------APVVE.......RVR-FQ----SPAAAAG.ILV..............NDVIVAA--DN------
Q1D977_MYXXD/477-552..........------..VAV........VM-DG----SPAQDAG.LYV..............EDDLVAL--NG------
C8X5D5_DESRD/676-755.........G------VVVQN........IH-DG----TPAVASG.LRT..............GDHILRF--QD------
B2IZX7_NOSP7/201-295.ALNLTSATG------VIVVN........VE-SS----GPADNAG.VLL..............GDILVTF--DG------
B5HUE3_9ACTN/403-492.......SGG------AKITTEGAGGSAPVE-SG----GPAAKAG.LKP..............GDVITKL--DD------
D2QHW4_SPILD/97-182.........G------KSIVL.......MVY-EG----TPAEKSG.LQI..............GDEVLKV--DG------
A2TY74_9FLAO/100-182.........S------ITVIQ........PI-KG----GPSIKAG.IKA..............GDRILMA--NS------
F3Z8A9_9ACTN/527-616.......MDG------ATVSDQGAGSDPAVT-PG----GPAAKAG.LKS..............GDTITKF--DD------
G2SPM5_LACRR/328-425LNLPSKVTSG------VVVIK........VN-SS----SPLKKTD.ISK..............YDVIVSL--GG------
O24877_HELPY/170-247.........R------LV...........VV-QF----DPFFPKNPFLK..............NDEILAI--NH------
Q0P7Y5_CAMJE/170-244.........K------IYVNN........VR-KN----.P....Q.FLI..............NDQVISV--DG------
Q5HNH7_STAEQ/304-394KELHTHKDKG------VYVAK........VD-SE----NA......IKK..............GDIITGI--DG------
Q79HP3_WOLSU/168-242.........E------PV...........VA-LI----DPFIEENLFRL..............GDRVLSL--EG------
Q8DMW2_STRR6/293-388LNIPSNVTSG------VIVRS........VQ-SN----MPANGH..LEK..............YDVITKV--DD------
Q8Y5K8_LISMO/122-196.........G------VYVLS........VK-DD----VPAADV..LHA..............GDLITEI--DG------
Q99XG9_STRP1/301-396INIPTSVTGG------IVVAE........VK-EG----MPASGK..LAQ..............YDVITEI--DG------
Q9HSH6_HALSA/244-350..NGLTESRG------LLVMS........VD-PS----GPSAGRL.VGSDATTIVDGGAVRVGGDIVLAV--NG------
R5FHL8_9CLOT/166-248.......TGL------CTIVK........VF-EG----SPALEAG.MQP..............GDIIYKV--GD------
R5KJ64_9CLOT/126-209.......TGY------AIAVS........IT-ED----SPASEAD.IKP..............DDLICKI--DD------

PF00595

DVL1_MOUSE/251-336......GDGG------IYIGS--------IM-KG--..GAVAADGRIEP--------------GDMLLQV..ND...---
ZO1_MOUSE/23-107....QSGETS------IVISD--------VL-KG--..GPAEGQ..LQE--------------NDRVAMV..NG...---
ZO1_MOUSE/186-261.........H------IFVKE--------IS-QD--..SLAARDGNIQE--------------GDVVLKI..NG...---
ZO1_MOUSE/423-501.........G------IFVAG--------VL-ED--..SPAAKEG.LEE--------------GDQILRV..NN...---
AFAD_HUMAN/1009-1090......DKLG------IYVKS--------VV-KG--..GAADVDGRLAA--------------GDQLLSV..DG...---
PTN3_HUMAN/510-595........MP------LVVSR--------IN-PE--.SPADTCIPKLNE--------------GDQIVLI..NG...---
SP4B_BACSU/103-184........VG------FHQIN--------TS-EG--KKSPGETAG.IEA--------------GDIIIEM..NG...---
CTPA_SYNP2/102-182........DV------LEVIL--------PL-PG--..SPAEAAG.IEA--------------KDQILAI..DG...---
PDLI1_RAT/5-82........QP------LAISR--------VT-PG--.SKAAIAN..LCI--------------GDLITAI..DG...---
APBA1_HUMAN/656-740......ILPT------VIIAN--------MM-HG--..GPAEKSGKLNI--------------GDQIMSI..NG...---
APBA2_MOUSE/660-733.........N------GIICS--------LM-RG--..GIAERGG.VRV--------------GHRIIEI..NG...---
DLG1_DROME/216-300.....GTDTS------IYITK--------LI-SG--..GAAAADGRLSI--------------NDIIVSV..ND...---
DLG1_DROME/330-418.....PGDNG------IYVTK--------LM-DG--..GAAQVDGRLSI--------------GDKLIAVRTNGS..---
DLG1_DROME/506-584........QG------IYVSF--------IL-AG--..GPADLGSELKR--------------GDQLLSV..NN...---
PDLI4_HUMAN/4-81........AP------LTISR--------VH-AG--.SKAALAA..LCP--------------GDLIQAI..NG...---
DSH_DROME/252-337......GDGG------IYVGS--------IM-KG--..GAVALDGRIEP--------------GDMILQV..ND...---
EM55_TAKRU/73-151.........R------CSVAR--------IL-HG--..GMIHRQGSLHE--------------GDEIAEI..NG...---
EM55_HUMAN/71-149.........S------CTVAR--------IL-HG--..GMIHRQGSLHV--------------GDEILEI..NG...---
DEGQ_ECOLI/257-346...NLDVQRG------AFVSE--------VL-PG--.SGSAKAG..VKA--------------GDIITSL..NG...---
DEGQ_ECOLI/365-444......GGKG------IKIDE--------VV-KG--.SPAAQAG..LQK--------------DDVIIGV..NR...---
DEGS_ECOLI/248-336...GIDQLQG------IVVNE--------VS-PD--.GPAANAG..IQV--------------NDLIISV..DN...---
DEGS_HAEIN/242-322........EG------IVITD--------VS-PN--.SPAAKSG..IQV--------------GDVILKL..NN...---
HTOA_HAEIN/268-358...NVSAQQG------AFVSE--------VL-PK--..SAAEKAG.LKA--------------GDIITAM..NG...---
HTOA_HAEIN/377-455.......VKG------IEITK--------IQ-PN--.SLAAQRG..LKS--------------GDIIIGI..NR...---
DEGPL_BARHE/289-378...GLKEAKG------ALITD--------PL-KG--..PAAKAG..IKA--------------GDVIISV..NG...---
DEGP_ECOLI/279-368...KVDAQRG------AFVSQ--------VL-PN--.SSAAKAG..IKA--------------GDVITSL..NG...---
DEGP_SALTY/386-464......QDKG------VVVSS--------VK-AN--.SPAAQIG..LKK--------------GDVIIGA..NQ...---
LIMK1_HUMAN/165-255...GTEHSHT------VRVQG--------VD-PG--.CMSPDVKNSIHV--------------GDRILEI..NG...---
LIMK2_CHICK/152-236......YATG------VQVKE--------VN-RM--.HISPDVRNAIHP--------------ADRILEI..NG...---
LIMK2_RAT/152-236......YATT------VQVKE--------VN-RM--.HISPNNRNAIHP--------------GDRILEI..NG...---
LIN2_CAEEL/546-624.........R------CFVAR--------IM-HG--..GMIHRQATLHV--------------GDEIREI..NG...---
NOS1_HUMAN/17-96........PP------VIISD--------LI-RG--..GAAEQSGLIQA--------------GDIILAV..NG...---
PRC_HAEIN/244-328.........E------ISIKS--------LV-PG--..APAERSKKLHP--------------GDKIIGV..GQATG---
DLG4_RAT/65-149.....GDDPS------IFITK--------II-PG--..GAAAQDGRLRV--------------NDSILFV..NE...---
DLG4_RAT/160-244.....PGDNS------IYVTK--------II-EG--..GAAHKDGRLQI--------------GDKILAV..NS...---
DLG4_RAT/313-391........EG------IFISF--------IL-AG--..GPADLSGELRK--------------GDQILSV..NG...---
PTN4_HUMAN/516-602........MP------VIVSR--------VA-PG--.TPADLCVPRLNE--------------GDQVVLI..NG...---
PTP1_CAEEL/616-703........YP------VIVSR--------VA-PG--.SSADKCQPRLNE--------------GDQVLFI..DG...---
SIPA1_MOUSE/682-754.........E------GFITH--------VE-RF--..TFAETTG.LRP--------------GARLLRV..CG...---
RSEP_ECOLI/203-277.........E------PVLEN--------VQ-PN--..SAASKAG.LQA--------------GDRIVKV..DG...---
PSMD9_YEAST/99-191DQAIQYTIPF------AFISE--------VV-PG--.SPSDKAD..IKV--------------DDKLISI..GN...---
NM111_YEAST/290-375....FPENIG------LLVAE--------TV-LR--.EGPGYDK..IKE--------------GDTLISI..NG...---
YQI7_CAEEL/25-114..PFKYPDSG------VYITN--------VE-SG--..SPADVAG.LRK--------------HDKILQV..NG...---
PRC_ECOLI/238-320.........Y------TVINS--------MV-AG--..GPAAKSKAISV--------------GDKIVGV..GQTGK---

PF14685

TRIC_SULTO/556-640---------N..KC..YKIAR--------IY-VG--DPTNENERSPLRDPGVQLNI-------GDCIKAV--DG------
TRI_THEAC/763-849---------G..DH..YVVAK--------AY-AG--DYSNEGEKSPIFEYGIDP.T-------GYLIEDI--DG------
Q4J6J4_SULAC/709-795---------EQREC..FKIVK--------IY-SG--DPTNEGERSPLKDPGVELNE-------GDCIYSI--DG------
A5US97_ROSS1/783-872---------T..DS..YVVER--------VI-RG--DVWDERASSPLAQPGINIVP-------GDRLIAV--GG------
D3Q8U1_STANL/765-853---------T.DGA..HTIAK--------IY-TG--DPWKPDATSSLLRPGVDARV-------GDTVVAV--NG------
Q8ZXG0_PYRAE/721-807---------G..KC..WRIAK--------IF-VG--DPSYENEKSPLLAPGVDVRE-------GDCIISI--AG------
E8WXR8_GRATM/803-890---------N..NQ..YCIAK--------LY-DG--GHWNPNMTGPLTQPGLNVHV-------GDCITAI--GG------
D2AWH2_STRRD/739-825---------D..GL..YRVAR--------IV-NG--DRWDPEVTSPLNRLGVDVRP-------GDVVLAV--NG------
Q020G3_SOLUE/804-893---------N..GR..YRFKK--------IY-AG--ESWNPQVQSPLTQPGLNVNE-------GDYLLAV--NG------
B0VF46_CLOAI/747-837---------K..KG..YEIIR--------IL-KG--DYWLSENRSPFMNPGLNVSE-------GWIIKAV--NG------
A9BIW8_PETMO/751-841---------E..DRKLYKISH--------IV-KG--DIWDEKNKPPLLGPGVEVKE-------GDYLLAI--NG------
B3QU45_CHLT3/747-837---------K..KA..FEVTG--------LP-KG--DFWKEGEASPLHTPGVNVQV-------GDLILEV--NG------
D9QMJ3_BRESC/796-884---------G..GR..WCITK--------IY-GP--TAFSPDVTGPLAQPGVDARV-------GDCVLSV--DD------
C6WJJ9_ACTMD/754-843---------D..GS..WRIAR--------VI-PG--ETSDPAARSPLSAPGVAVRA-------GDVITAV--DG------
E4NAZ7_KITSK/757-844---------G..EV..WRVAR--------VL-PG--ESSDPRARSPLAAPGAAVRP-------GDALLAV--NG------
C7Q5E5_CATAD/793-881---------E.DGV..WRIVK--------IL-PG--DNSVPAARSPLLAPGIAARV-------GDAITAV--DG------
E4RW77_LEAB4/768-855---------G..NH..YKVGK--------II-RG--ASWDAEVRSPLEKSGIK..E-------GSYILEV--NG------
C1N9P1_MICPC/828-915---------A..KMRGYRITH--------IV-GG--DQWDDLTGGALRKPGLNVAV-------GDAIVAL--NR------
D2ARY8_STRRD/732-815---------D..GR..WQVDR--------VL-PG--ESSDVHARSPLAVPGAGIQQ-------GETLLAV--DG------
B5GPX5_STRC2/828-913---------D..GR..WVVRR--------IL-PG--ESSDSKARSPLAGTGIP..E-------GAVITHV--DG------
B5HKU3_9ACTN/746-831---------E..GG..WTVRR--------IL-PG--DSSDSKARSPLAGTGIR..E-------GAVLTHV--DG------
E4NBJ1_KITSK/740-825---------D..GR..WLVDR--------IL-PG--ESSDPKARAPLAGHGLR..D-------GDELLAV--DG------
A6KZI1_BACV8/751-841---------K.SGF..YRIDK--------IL-PG--AIYSQKLRSPLTEPGIGVKE-------GDYITAI--DG------
A6LFH5_PARD8/757-847---------K.SGF..FRLEK--------IL-PG--ASWSKELRSPLTEPGVEAKA-------GEYIVAI--DG------
F3Z9P9_9ACTN/761-850---------D..GQ..WHVDR--------VL-PS--ETSDPHARSPLAGPGIAVRA-------GDTLLAV--GG------
F3ZGH8_9ACTN/873-959---------D..GA..WELRR--------IL-PG--ESSDPRARSPLAGTGIR..E-------GAVLTHV--DG------
TRI_SULSO/773-858---------N..KC..YKITK--------IY-VG--DSTNENERSPLRDPGVQLNV-------GDCIKNI--DG------
Q5LCE8_BACFN/758-848---------K.SGF..FRLEK--------IF-PG--ASWSKELRSPLTEPGVDVKV-------GEYIVAI--DG------
V4IJ74_9ACTN/752-841---------E..GV..WRVER--------VL-PS--ETSDPHAHSPLAAPGVAVRA-------GDAILAV--DG------
V4J1V6_9ACTN/791-877---------G..DQ..WMLRR--------IL-PG--DSSDTKARSPLAGTGIR..E-------GAALTHV--DG------

PF04495

Q2LYW0_DROPS/69-205----GANESV------WHILE--------VH.PN----SPAELAG.LRAY-------------SDYVIGA--D.......
Q0U7P0_PHANO/83-216----.LAEDV------WHILD--------VA.PN----SPADVAG.LLPY-------------GDYVIGS--PE......
Q6BX19_DEBHA/130-306----.TATYV------WRILN--------TH.HN----SPAFQAQ.LIPY-------------SDYIIGC--DSAYPQDA
A5DBW3_PICGU/154-329----.TATYV------WRILQ--------TH.MG----SPAFQAQ.LVPY-------------SDYIIGC--DSASPDEP
GORS2_MOUSE/69-205----GANENV------WHVLE--------VE.SN----SPAALAG.LRPH-------------SDYIIGA--D.......
Q0IEU2_AEDAE/69-205----GANENV------WHILE--------VH.PS----SPAEEAG.LIPF-------------TDYIIGA--D.......
Q5KDT5_CRYNJ/68-205----HALESV------YHVLD--------VL.EG----SPAEMAG.LVPW-------------GDYVLAW--SG......
YAT2_SCHPO/80-213----PAVDAI------WHILN--------VI.DD----SPVARAS.LVPY-------------EDYIVGT--PE......
GORS1_MOUSE/68-204----RASEHV------WHVLD--------VE.PS----SPAALAG.LCPY-------------TDYIVGS--D.......
Q4UCI6_THEAN/70-205----.CLDEG------AHIVH--------VY.DK----SPAQKAG.LMPI-------------TDYLLGT--NL......
Q54C46_DICDI/73-210----KTLENV------WHVLD--------VY.LN----SPAHEAE.LQTR-------------LDYIVGT--PD......
Q2UN33_ASPOR/80-214----.STQHI------WHVLN--------IPSPL----SPAYRAG.LLPH-------------SDYIIGT--PS......
A7ARE9_BABBO/70-205----.AMDEG------AHVIN--------VH.DG----SPAKKAG.LMPI-------------TDYLLGT--NL......
Q4Q3U9_LEIMA/103-265----ACPERC------VHVVD--------VL.EG----SPAACSTELQAN-------------RDYIIGM--QTVQE...
Q22G20_TETTS/89-227----NSHDNT------FKVVT--------VD.EN----SPAKIAG.LQAK-------------QDYIIGL--KK......
Q386P4_TRYB2/73-244----KCVERC------WHVVD--------VI.PG----SPVAKCGEIKEG-------------RDYIIGI--QKADE...
A0A0D1CDK1_USTMA/83-237----QALSHV------WHILE--------IL.EG----SPAESAG.LVPF-------------GDFVIGW--PG......
Q2HFQ7_CHAGB/78-211----.VVSNI------WHVLD--------VP.AN----SPADAAG.LLPY-------------SDYILGT--PE......
B0S774_DANRE/70-205----GANENV------WHVLD--------VE.SN----SPAALAG.LQEH-------------SDFIVGA--D.......
E7KBH0_YEASA/142-281----.ASTFT------YHILN--------VNIPD----GPAQSAG.LIPD-------------EDYIIGC--QD......

PF12812

NM111_ASHGO/373-450---------M------ARYYA--------IP-VR..AVFLSSATGSFCF......DTK..EKLGWIVDEV--NN------
B8MUN1_TALSN/264-341---------Q------ARLYA--------IA-CR..GVYVCEAAGSFKI......DDN..TPSGWIIDSV--GR------
NM111_PICST/379-456---------V------ARCYC--------IP-VK..GVFINDASGSFEF......ASY..EKSGWLLETV--DD------
NM111_PICGU/388-465---------V------ARCFC--------IP-VR..GVFINDGSGSFEL......SPF..EKNGWLLEYV--DD------
NM111_LODEL/379-456---------V------ARCYC--------LP-VR..GLYVCDGSGSFEF......SNQ..DTLGFIVETV--DD------
C5MEA8_CANTT/370-447---------I------ARSFG--------LP-VK..GVFVNHGAGSFEF......SSQ..DTLGWFIQAV--DD------
NM111_CANGA/374-451---------M------ARFYA--------LP-IR..GVFLSSASGSFNF......DNK..EKIGWIVDSV--NY------
NM111_KLULA/388-465---------M------ARCYA--------LP-VK..GVFVASATGSFDL......DPK..EKTGWVIDFV--DN------
C4R214_PICPG/366-443---------M------ARLYA--------IP-VR..GVFANRASGSFTL......DTR..DRCGWIIDSL--DH------
NM111_YARLI/360-439---------L------ARIYA--------IP-VR..GVYVSEVGGSFRL......DGQGNESKGWVVDSI--DD------
B6JWG1_SCHJY/372-448---------L------ARQYA--------LP-VR..RVFISEPTGSFYL......EG...SDYGYLLESI--AH------
B2WNT3_PYRTR/845-923---------A------VRQQI--------SK-IHSDVYISSRARGSPAY......MYG..LAPTNFVTHV--NN------
C4Y709_CLAL4/134-212---------S------VRQLM--------EK-IPSEVYVARKSAGGPMT......QYG..ISNSVFITHV--ND------
NM111_KLULA/861-937---------A------VRQVK--------TS-IPSEVYAVSRGTSSLAL......QYG..IEVTNFITHV--ND------
Q6CHS4_YARLI/371-442---------L------VRSTN--------EP-ID..GVIVACGGPTD.............VNCRSKLYKI--NG------
B6QC43_PENMQ/337-413---------T------AVCWK--------VP-LK..GMFLASSAINFSL......GD...ESNSYIISSI--NN------
A9RQ61_PHYPA/347-422---------Q------ARNLH--------FV-CG..IVYVAEPGYMLSC......AG...VPRHAIIKKM--AG------
A8JH35_CHLRE/368-444---------Q------ARNNR--------AV-VG..QVYVAEPGYMLGR......AN...VPKCAIITGL--NG------
C1EGI7_MICSR/349-424---------Q------ARNFQ--------LP-VG..SVYVAEPGYVLGL......AG...LSKHAIITSL--NN------
C1N456_MICPC/359-434---------Q------ARNFQ--------LP-CG..GVYVAEPGYVLGV......AN...VPKHAILTSL--GN------
YH05_SCHPO/393-469---------L------ARSYQ--------FS-LN.SGTYVA.SSGMLNW......SS...GTRDFLVTRL--AN------
B8FNF0_DESAA/337-420---------I------RLDLD--------IA-SD..GVYLSQAELGSTFGSVGYSSSRNPDRKGVVVQGI--NG------
NM111_MAGO7/393-469---------Q------ARLYG--------VA-CK..GVYVCEATGSFRF.......ET..SDNGWILQTI--DN------
B2ASP9_PODAN/396-472---------Q------ARLYG--------VA-CK..GVYVCEAGGSWRF.......ES..SECGWLIQTV--DH------
B2WNT3_PYRTR/372-451---------Q------ARLYA--------IS-LKGAGVYVCEAAGSFRF......ADG..YTSGWLIQEV--DN------
C0NX23_AJECG/394-470---------Q------ARLYA--------IA-CK..GVYVCEAAGSFKL.......EN..TFSGWIVDTV--DK------
B6HPJ1_PENCW/491-567---------Q------SRLYA--------IA-TR..GVYVCESAGSFKL.......EN..TVAGWIIDSI--DK------
B6K3R7_SCHJY/399-475---------L------ARSYQ--------CA-FN.SGTFVA.ASGMLNW......SG...GTRDFLVTKL--AN------
NM111_YEAST/392-469---------M------ARFYA--------LP-VR..GVFLSSASGSFNF......DSK..ERVGWIVDSI--DN------
Q5A946_CANAL/376-453---------I------ARCYG--------LP-VK..GVFVNGGTGSFEF......SPQ..DTLGWMIESV--DD------
Q6ZIR2_ORYSJ/179-252---------Q------ARNFR--------FK-CG..LVYVAEAGYMLSR......AS...VPRHAIIKKL--AG------
Q7MWL5_PORGI/399-469---------Q------MRSYG--------VS-YG..VEVTSVSSGKFKD......AG...IKKGFIILSI--NR------

PF13180

C9A6A9_ENTCA/322-419-----TEV...STT-TDLQ.....-----------------------------.SALY..KHKVG--D-----TITVTFY
Q7VJB0_HELHP/178-253-----AKV...QTS-DEAE.....-----------------------------.WVMS..NLKKD--S-----LAQVTLL
A7ZFX4_CAMC1/179-256-----IKP...KSL-RELN.....-----------------------------.EMVL..FAPKG--A-----RLDIIVK
Q0S4Y2_RHOJR/404-487-----RVI...TSG-DALI.....-----------------------------.AAIR..SHAPG--D-----NVSITYT
D1BL26_VEIPT/269-359-----KDI...TTL-LELK.....-----------------------------.ERID..AKSPG--D-----TVLVSYT
B1VP64_STRGG/452-541-----TVI...DSG-PTLI.....-----------------------------.GEIW..TRKPG--E-----KVTLTYE
D2R087_PIRSD/256-349-----VPV...IDD-LHLI.....-----------------------------.RLLS..GMFAG--S-----EVTLTVE
Q30TR4_SULDN/163-240-----RKV...KDS-ASFM.....-----------------------------.RNIL..FSSIG--S-----THNVKIK
A0RM44_CAMFF/175-252-----KVP...NNL-REIN.....-----------------------------.EMIL..FAPKD--A-----VLKFDIN
C9ZC44_STRSW/506-595-----HVI...DSG-PTLI.....-----------------------------.GEIW..THRPG--D-----KVTLTYT
B1XQ68_SYNP2/485-563-----YRT....NA-EQLN.....-----------------------------.HRLQ..NYQAG--D-----TISITIF
A9B2Z4_HERA2/473-551-----WRI....DE-DGLN.....-----------------------------.KRLA..DYPIG--A-----TVQLSFF
Q315Q4_DESAG/369-449-----AQV...NSL-WDMH.....-----------------------------.KAGM.QAAREK--R-----PVVFGVQ
D5SYB3_PLAL2/269-351-----IPI...ARL-GNLK.....-----------------------------.HVLG..RKYAG--D-----QLQLKIL
Q1D977_MYXXD/477-552-----WKV....DG-ATLL.....-----------------------------.SRCE..ERRPG--E-----TVRLTVF
C8X5D5_DESRD/676-755-----RAE...TDV-ASLV.....-----------------------------.EAVR..ACTPG--Q-----RVNLQVR
B2IZX7_NOSP7/201-295-----VTV...GDT-GDVL.....-----------------------------.ALLN.SSDRIG--K-----TVNLQVI
B5HUE3_9ACTN/403-492-----HVI...DSG-PTLI.....-----------------------------.GEIW..THKPG--D-----KVKITYE
D2QHW4_SPILD/97-182-----VDL...KTR-KDRDGGPLD-----------------------------PGKLL..KGQNN--T-----AVKLTVS
A2TY74_9FLAO/100-182-----DTLFGKNLR-TGSV.....-----------------------------.PKYL..KGKPN--T-----DVSLQVY
F3Z8A9_9ACTN/527-616-----TII...DSG-PTLI.....-----------------------------.GEIW..THQPG--D-----KVKITYK
G2SPM5_LACRR/328-425-----KKV...SGL-SSLR.....-----------------------------.TALY..GHKVG--D-----TVEIQYY
O24877_HELPY/170-247-----QKI...HSL-AEFE.....-----------------------------.WVVS..NLKYQ--S-----LAKVEIK
Q0P7Y5_CAMJE/170-244-----LPA...NDL-RKLN.....-----------------------------.EKIL..FADRG--S-----TLYFQVL
Q5HNH7_STAEQ/304-394-----KQI...KDD-TDLR.....-----------------------------.TYLY.ESKKPG--E-----TVTLKVI
Q79HP3_WOLSU/168-242-----RAI...GSR-SELE.....-----------------------------.NQIY..GLAPG--R-----EVRVSVM
Q8DMW2_STRR6/293-388-----KEI...ASS-TDLQ.....-----------------------------.SALY..NHSIG--D-----TIKITYY
Q8Y5K8_LISMO/122-196-----NAF...KSS-QEFI.....-----------------------------.DYIH..SKKVG--D-----TVKINYK
Q99XG9_STRP1/301-396-----KTV...NSI-SDLQ.....-----------------------------.SSLY..GHDIN--D-----TIKVTFY
Q9HSH6_HALSA/244-350-----TRV...HTL-EDVL.....-----------------------------.SLLA.LHTSPG--D-----TVSVRLL
R5FHL8_9CLOT/166-248-----TLVA.SESL-DVLV.....-----------------------------.NNYI..KGEEG--T-----DVAITVY
R5KJ64_9CLOT/126-209-----YEI...QES-DDLD.....-----------------------------.YLVTKIRGEEG--T-----DVTLEIY

PF00595

DVL1_MOUSE/251-336---..VNF---ENM.SNDD-----------------------------------AVRV--LREIV--SQ..TGPISLTVA
ZO1_MOUSE/23-107---..VSM---DNV.EHAF-----------------------------------AVQQ--LRKSG--K.....NAKITIR
ZO1_MOUSE/186-261---..TVT---ENM.SLTD-----------------------------------AKTL--IERSK--G.....KLKMVVQ
ZO1_MOUSE/423-501---..VDF---TNI.IREE-----------------------------------AVLF--LLDLP--KG...EEVTILAQ
AFAD_HUMAN/1009-1090---..RSL---VGL.SQER-----------------------------------AAEL--MTRTS--S.....VVTLEVA
PTN3_HUMAN/510-595---..RDI---SEH.THDQ-----------------------------------VVMF--IKASR--ESH.SRELALVIR
SP4B_BACSU/103-184---..QKI---EKM.NDVA-----------------------------------PFIQ--KAGKT--G....ESLDLLIK
CTPA_SYNP2/102-182---..IDT---RNI.GLEE-----------------------------------AAAR--MRGKK--G....STVSLTVK
PDLI1_RAT/5-82---..EDT---SSM.THLE-----------------------------------AQNK--IKGCV--D.....NMTLTVS
APBA1_HUMAN/656-740---..TSL---VGL.PLST-----------------------------------CQSI--IKGLK--NQ...SRVKLNIV
APBA2_MOUSE/660-733---..QSV---VAT.AHEK-----------------------------------IVQA--LSNSV--G.....EIHMKTM
DLG1_DROME/216-300---..VSV---VDV.PHAS-----------------------------------AVDA--LKKAG--N.....VVKLHVK
DLG1_DROME/330-418---.EKNL---ENV.THEL-----------------------------------AVAT--LKSIT--D.....KVTLIIG
DLG1_DROME/506-584---..VNL---THA.THEE-----------------------------------AAQA--LKTSG--G.....VVTLLAQ
PDLI4_HUMAN/4-81---..EST---ELM.THLE-----------------------------------AQNR--IKGCH--D.....HLTLSVS
DSH_DROME/252-337---..VNF---ENM.TNDE-----------------------------------AVRV--LREVV--QK..PGPIKLVVA
EM55_TAKRU/73-151---..KSV---ANQ.TVDQ-----------------------------------LQKI--LKETN--G.....VVTMKII
EM55_HUMAN/71-149---..TNV---TNH.SVDQ-----------------------------------LQKA--MKETK--G.....MISLKVI
DEGQ_ECOLI/257-346---..KPL---NSF.AELR-----------------------------------SRIA--TTEPG--T.....KVKLGLL
DEGQ_ECOLI/365-444---..DRV---NSI.AEMR-----------------------------------KVLA--AKPA.--......IIALQIV
DEGS_ECOLI/248-336---.KPAI---SAL.ETMD-----------------------------------QVAE--IRPGS--......VIPVVVM
DEGS_HAEIN/242-322---..QEG---ISA.REMM-----------------------------------QIIA--NTKPN--S.....KVLVTIL
HTOA_HAEIN/268-358---..QKI---SSF.AEIR-----------------------------------AKIA--TTGAG--K.....EISLTYL
HTOA_HAEIN/377-455---..QMI---ENI.RELN-----------------------------------KVLE--TEPS.--......AVALNIL
DEGPL_BARHE/289-378---..EKI---NDV.RDLA-----------------------------------KRIA--NMSPG--E.....TVTLGVW
DEGP_ECOLI/279-368---..KPI---SSF.AALR-----------------------------------AQVG--TMPVG--S.....KLTLGLL
DEGP_SALTY/386-464---..QPV---KNI.AELR-----------------------------------KILD--SKPS.--......VLALNIQ
LIMK1_HUMAN/165-255---..TPI---RNV.PLDE-----------------------------------IDLL--IQETS--R.....LLQLTLE
LIMK2_CHICK/152-236---..API---RTL.QVEE-----------------------------------VEDL--IRKTS--Q.....TLQLLIE
LIMK2_RAT/152-236---..TPV---RTL.RVEE-----------------------------------VEDA--INQTS--Q.....TLQLLIE
LIN2_CAEEL/546-624---..MSV---ANR.SVES-----------------------------------LQEM--LRDAR--G.....QVTFKII
NOS1_HUMAN/17-96---..RPL---VDL.SYDS-----------------------------------ALEV--LRGIA--S.....ETHVVLI
PRC_HAEIN/244-328---DIEDV---VGW.RLED-----------------------------------LVEK--IKGKK--G....TKVRLEIE
DLG4_RAT/65-149---..VDV---REV.THSA-----------------------------------AVEA--LKEAG--S.....IVRLYVM
DLG4_RAT/160-244---..VGL---EDV.MHED-----------------------------------AVAA--LKNTY--D.....VVYLKVA
DLG4_RAT/313-391---..VDL---RNA.SHEQ-----------------------------------AAIA--LKNAG--Q.....TVTIIAQ
PTN4_HUMAN/516-602---..RDI---AEH.THDQ-----------------------------------VVLF--IKASC--ERH.SGELMLLVR
PTP1_CAEEL/616-703---..RDV---STM.SHDH-----------------------------------VVQF--IRSAR--SGLNGGELHLTIR
SIPA1_MOUSE/682-754---..QTL---PKL.GPET-----------------------------------AAQM--LRSAP--......KVCVTVL
RSEP_ECOLI/203-277---..QPL---TQW..VTF-----------------------------------VMLV--RDNPG--K.....SLALEIE
PSMD9_YEAST/99-191---..VHA---ANH.SKLQ-----------------------------------NIQM--VVMKN--ED...RPLPVLLL
NM111_YEAST/290-375---..ETI---SSFMQVDK-----------------------------------IQDE--NVGK.--......EIQLVIQ
YQI7_CAEEL/25-114---..ADF---TMM.THDR-----------------------------------AVKF--IKQSK--......VLHMLVA
PRC_ECOLI/238-320---PMVDV---IGW.RLDD-----------------------------------VVAL--IKGPK--G....SKVRLEIL

PF14685

TRIC_SULTO/556-640-----EEVK..YNI----------------------------------------LSYL--VNKDQ...-----.VVLDVI
TRI_THEAC/763-849-----ETVGAGSNI----------------------------------------YRVL--SEKAG..T-----SARIRLS
Q4J6J4_SULAC/709-795-----EKVRK.GSI----------------------------------------NSHF--INKDQ...-----.AILEVL
A5US97_ROSS1/783-872-----HRVGRNVSP----------------------------------------HELL--INQAG..S-----DVLLTFM
D3Q8U1_STANL/765-853-----QPVGPTTSV----------------------------------------AQLL--VNQAD..Q-----EVRLSLR
Q8ZXG0_PYRAE/721-807-----VRLGPNAPP----------------------------------------EYAL--LNRTS..D-----VVTVEVE
E8WXR8_GRATM/803-890-----KPLTAAEDI----------------------------------------QRPL--EGTAG..H-----AVTLRLA
D2AWH2_STRRD/739-825-----QPVGPSAGP----------------------------------------DERL--VNQAD..Q-----EVQLTVR
Q020G3_SOLUE/804-893-----QELQGTEDV----------------------------------------SRLL--ENTSG..K-----HVLLKIA
B0VF46_CLOAI/747-837-----IPVTKTIPP----------------------------------------ERLT--LNLAG..Q-----QVQLTVS
A9BIW8_PETMO/751-841-----IEIKDK.IP----------------------------------------NEFL--VNYSG..K-----DVEIVVS
B3QU45_CHLT3/747-837-----QSLSKNQSF----------------------------------------GELL--VSMAG..Q-----EITLTVA
D9QMJ3_BRESC/796-884-----RAVSADMDI----------------------------------------QSAL--EGTAG..R-----MVTLRLG
C6WJJ9_ACTMD/754-843-----RQVDPLTGP----------------------------------------APLL--VGTAG..K-----PVELVVR
E4NAZ7_KITSK/757-844-----RPVDPVTGP----------------------------------------APLL--AGTAD..H-----PVELTVR
C7Q5E5_CATAD/793-881-----LPVPPRVGP----------------------------------------AALL--AGKAD..Q-----PTELVLQ
E4RW77_LEAB4/768-855-----LPISTNKDP----------------------------------------YYYF--AGLNN..V-----AVELTYN
C1N9P1_MICPC/828-915-----VTLTEEVGV----------------------------------------DEVL--TGKGG..A-----EVMVTFK
D2ARY8_STRRD/732-815-----RPVPPQ.GP----------------------------------------ASLL--VGAAD..K-----AVELTLG
B5GPX5_STRC2/828-913-----RPVDPVAGP----------------------------------------FPML--AGAGG..T-----TVELTFR
B5HKU3_9ACTN/746-831-----RPVDELAGP----------------------------------------SPLL--AAAGG..T-----TVELTFT
E4NBJ1_KITSK/740-825-----RPPDPVRGP----------------------------------------APLL--AGTGG..S-----TVELTVR
A6KZI1_BACV8/751-841-----ISTATVDNI----------------------------------------YSLL--AGKAN..V-----LTELSIN
A6LFH5_PARD8/757-847-----VPTNSVNDM----------------------------------------YKLL--IGKAN..V-----PTELSLN
F3Z9P9_9ACTN/761-850-----RPVDPLLGP----------------------------------------GPLL--AGTAG..H-----VTELTIG
F3ZGH8_9ACTN/873-959-----RPVDPVTGP----------------------------------------APLL--AGAAG..T-----SVELTFA
TRI_SULSO/773-858-----ED..ANGNI----------------------------------------YSHL--INKDQ...-----.VILDVI
Q5LCE8_BACFN/758-848-----VPTNTVKDM----------------------------------------YSLL--VGKAEIPT-----EISLNVK
V4IJ74_9ACTN/752-841-----QPVDPVTGP----------------------------------------GPLL--VGTAG..K-----PVELTVS
V4J1V6_9ACTN/791-877-----RPVDPVTGP----------------------------------------YPLL--AGAGG..T-----TVELTFR

PF04495

Q2LYW0_DROPS/69-205...AIRH..ENDDLFTLIDTHEQQ.............................PLKMYVYNLDDDACR-----EVTIKPN
Q0U7P0_PHANO/83-216...GLVR..GESGLGELVEDFLNR.............................PLRLIVYNHEYDVTR-----PVTITPS
Q6BX19_DEBHA/130-306EGKGLLAKGGESLLSRTVMSYYNLHYSAS...................QEDNVPITLYVYNHDYDILR-----PVTVNLS
A5DBW3_PICGU/154-329QGQGLLTSGGEALLSRVVLNYYNQHYSKT...................NDDFVPITLYVYNHDYDILR-----PVTVNLS
GORS2_MOUSE/69-205...TVMN..ESEDLFSLIETHEAK.............................PLKLYVYNTDTDNCR-----EVIITPN
Q0IEU2_AEDAE/69-205...SILH..ESEDLFTLIESHKGR.............................PLKMYVYNIDRDACR-----EVTITPN
Q5KDT5_CRYNJ/68-205...GPLH..SENDFYNLIEAHVDK.............................PLRLFVYNADLDNLR-----EVVLYPT
YAT2_SCHPO/80-213...GMMT..GEKALSDLIESHLNR.............................PLRLYIYNHYRDSTR-----QVTIVPN
GORS1_MOUSE/68-204...QILQ..ESEDFFTLIESHEGK.............................PLKLMVYNSESDSCR-----EVTVTPN
Q4UCI6_THEAN/70-205...QLFY..DLDCVRIHVANKVDK.............................EVVLIVYNSVTETVR-----RALIVPR
Q54C46_DICDI/73-210...LILN..EQEDFFTLINNNMYR.............................PIQLYVYSSLTEQIR-----LVTITPN
Q2UN33_ASPOR/80-214...GTLR..GESALGELVEDHLDR.............................TLVLWVYNSEFDVVR-----EVELVPT
A7ARE9_BABBO/70-205...QLFV..DSDCVRVHVGERVDE.............................DVTLYVYNSVTETIR-----KTVITPR
Q4Q3U9_LEIMA/103-265TLITLIK..SQKDFYCRLEAWHEEQRWALERKQF.........FPNERVEVPHVLLFLVYNSESNTIE-----EVEV...
Q22G20_TETTS/89-227...YKYE..GLDELINIIFDNEGQ.............................EIELVVFNISDKSVR-----SVMLKPQ
Q386P4_TRYB2/73-244LVTALIK..DEDDLYTRVELWRTAQSAALRRLQRNSFVPTGASREDRGLQTAGQLLLLVYDSVNIEVK-----EVLV...
A0A0D1CDK1_USTMA/83-237...GVLQ..AEGDFYELVEAHTDR.............................ALRLYVYNSDYDHTR-----EVIIVPN
Q2HFQ7_CHAGB/78-211...GVLH..GEGGLSELVEDHIGR.............................PLRLYVYNNEYNVTR-----EVTIQPS
B0S774_DANRE/70-205...QVLQ..DSEDFFSLIEAHEGK.............................PLKLLIYNTETDKCR-----EVIVTPN
E7KBH0_YEASA/142-281...GLLATGGETLLQDIVRSRANY.............................DLVLYVYNKVSDCVR-----PITV...

PF12812

NM111_ASHGO/373-450-----QPTPTLDTF----------------------------------------IEVM--STIPD--C------------
B8MUN1_TALSN/264-341-----QPTRNLQEF----------------------------------------IQVM--KTIPD--R------------
NM111_PICST/379-456-----MPTPDLDTL----------------------------------------IEVM--KMIPD--C------------
NM111_PICGU/388-465-----KPTPNLDAF----------------------------------------VEVM--KSIPD--R------------
NM111_LODEL/379-456-----KPVANLDEF----------------------------------------VEVM--KQLPD--C------------
C5MEA8_CANTT/370-447-----VPVGNLDEF----------------------------------------VEAM--KNVPD--K------------
NM111_CANGA/374-451-----QDTPNLDAF----------------------------------------VEVM--KTIPD--K------------
NM111_KLULA/388-465-----KETPTLDDF----------------------------------------IEVM--KTIPD--E------------
C4R214_PICPG/366-443-----KDTPDLDTF----------------------------------------IEVL--KSIPD--C------------
NM111_YARLI/360-439-----IDTPDLDTF----------------------------------------IKVI--AAIPD--G------------
B6JWG1_SCHJY/372-448-----KPVPDLDAF----------------------------------------IEVM--KTLPD--R------------
B2WNT3_PYRTR/845-923-----VPTPNLSAF----------------------------------------LTEI--KKIKD--N------------
C4Y709_CLAL4/134-212-----QETPDLETF----------------------------------------VKIT--NDIPD--N------------
NM111_KLULA/861-937-----QSTPDLDTF----------------------------------------LKVV--KEIPD--N------------
Q6CHS4_YARLI/371-442-----KKISNLTEL----------------------------------------KEFF--KNA.V--H------------
B6QC43_PENMQ/337-413-----HPTRNVIEG----------------------------------------EKVL--SKLKD--R------------
A9RQ61_PHYPA/347-422-----EEIDNLDKF----------------------------------------ISVF--FKL.S--R------------
A8JH35_CHLRE/368-444-----KPTPDLITF----------------------------------------ATVL--RTLPH--G------------
C1EGI7_MICSR/349-424-----VPTPDLDAF----------------------------------------ANAY--ARL.E--E------------
C1N456_MICPC/359-434-----TPTPDLDAF----------------------------------------AAAY--AKL.K--E------------
YH05_SCHPO/393-469-----KPTPTLDAF----------------------------------------IDVL--VQLTD--N------------
B8FNF0_DESAA/337-420-----QPVRNLDDF----------------------------------------IRLA--SALKH--N------------
NM111_MAGO7/393-469-----KKVPDLETF----------------------------------------IQVV--KNIPD--K------------
B2ASP9_PODAN/396-472-----KKTPDLDTF----------------------------------------IDVL--KGIPD--K------------
B2WNT3_PYRTR/372-451-----QPTPDLDTF----------------------------------------IQVM--KKIPD--R------------
C0NX23_AJECG/394-470-----RPTKNLDEF----------------------------------------IEVV--KTIPD--R------------
B6HPJ1_PENCW/491-567-----RPVRNLNEF----------------------------------------VEVM--KNIPD--R------------
B6K3R7_SCHJY/399-475-----IPTPNLEAL----------------------------------------TKVI--LGLRD--N------------
NM111_YEAST/392-469-----KETPDLDTF----------------------------------------IEIM--KTIPD--R------------
Q5A946_CANAL/376-453-----ERVEDLDEF----------------------------------------VEVM--KKIPD--C------------
Q6ZIR2_ORYSJ/179-252-----EDIENLGDL----------------------------------------IACI--SKL..--.------------
Q7MWL5_PORGI/399-469-----QPVSSGADV----------------------------------------SDIV--R....--.------------

PF13180

C9A6A9_ENTCA/322-419R......GDEEKTAEVKL---------
Q7VJB0_HELHP/178-253R......NGKTLNLKVKV---------
A7ZFX4_CAMC1/179-256R......DREQLLFQVPV---------
Q0S4Y2_RHOJR/404-487DG....NGSNTKTVDVTL---------
D1BL26_VEIPT/269-359H......NGKMKSTQIKL---------
B1VP64_STRGG/452-541R......DGKEATAEVTL---------
D2R087_PIRSD/256-349RGSSTLLNARKLDLEVLL---------
Q30TR4_SULDN/163-240R......DNKIVTLRAIT---------
A0RM44_CAMFF/175-252R......DGKNQSYSIKM---------
C9ZC44_STRSW/506-595R......DGKTRTADVTL---------
B1XQ68_SYNP2/485-563H......QDQLKTLAVTL---------
A9B2Z4_HERA2/473-551R......RDELLHVPVTF---------
Q315Q4_DESAG/369-449R......DGAMLSLELSV---------
D5SYB3_PLAL2/269-351R......KKDPLEVTIPL---------
Q1D977_MYXXD/477-552R......RDRLLEIPVVL---------
C8X5D5_DESRD/676-755R......GDTLQTVSLDT---------
B2IZX7_NOSP7/201-295R......GGVLIELAIAV---------
B5HUE3_9ACTN/403-492R......DGQTHTVDLTL---------
D2QHW4_SPILD/97-182R......YGQKAPLELSV---------
A2TY74_9FLAO/100-182R......KSNDSLFNVNI---------
F3Z8A9_9ACTN/527-616R......DGSEHTTEVTL---------
G2SPM5_LACRR/328-425H......KGELKKANVKL---------
O24877_HELPY/170-247R......NHKVKEVTLKV---------
Q0P7Y5_CAMJE/170-244R......DNMDLNISTEV---------
Q5HNH7_STAEQ/304-394R......DGKTQDINVKL---------
Q79HP3_WOLSU/168-242R......EGEVVSFET..---------
Q8DMW2_STRR6/293-388R......NGKEETTSIKL---------
Q8Y5K8_LISMO/122-196H......GDKNEQADIKL---------
Q99XG9_STRP1/301-396R......GTTKKKADIKL---------
Q9HSH6_HALSA/244-350R......DGDRRTVDVEL---------
R5FHL8_9CLOT/166-248R......ADKDEYVDMSV---------
R5KJ64_9CLOT/126-209R......PSERKYYTVTL---------

PF00595

DVL1_MOUSE/251-336---------------------------
ZO1_MOUSE/23-107---------------------------
ZO1_MOUSE/186-261---------------------------
ZO1_MOUSE/423-501---------------------------
AFAD_HUMAN/1009-1090---------------------------
PTN3_HUMAN/510-595---------------------------
SP4B_BACSU/103-184---------------------------
CTPA_SYNP2/102-182---------------------------
PDLI1_RAT/5-82---------------------------
APBA1_HUMAN/656-740---------------------------
APBA2_MOUSE/660-733---------------------------
DLG1_DROME/216-300---------------------------
DLG1_DROME/330-418---------------------------
DLG1_DROME/506-584---------------------------
PDLI4_HUMAN/4-81---------------------------
DSH_DROME/252-337---------------------------
EM55_TAKRU/73-151---------------------------
EM55_HUMAN/71-149---------------------------
DEGQ_ECOLI/257-346---------------------------
DEGQ_ECOLI/365-444---------------------------
DEGS_ECOLI/248-336---------------------------
DEGS_HAEIN/242-322---------------------------
HTOA_HAEIN/268-358---------------------------
HTOA_HAEIN/377-455---------------------------
DEGPL_BARHE/289-378---------------------------
DEGP_ECOLI/279-368---------------------------
DEGP_SALTY/386-464---------------------------
LIMK1_HUMAN/165-255---------------------------
LIMK2_CHICK/152-236---------------------------
LIMK2_RAT/152-236---------------------------
LIN2_CAEEL/546-624---------------------------
NOS1_HUMAN/17-96---------------------------
PRC_HAEIN/244-328---------------------------
DLG4_RAT/65-149---------------------------
DLG4_RAT/160-244---------------------------
DLG4_RAT/313-391---------------------------
PTN4_HUMAN/516-602---------------------------
PTP1_CAEEL/616-703---------------------------
SIPA1_MOUSE/682-754---------------------------
RSEP_ECOLI/203-277---------------------------
PSMD9_YEAST/99-191---------------------------
NM111_YEAST/290-375---------------------------
YQI7_CAEEL/25-114---------------------------
PRC_ECOLI/238-320---------------------------

PF14685

TRIC_SULTO/556-640TK.G...KTKRVTV-------------
TRI_THEAC/763-849GK.GG..DKRDLMI-------------
Q4J6J4_SULAC/709-795TS.DG..KNRTVSV-------------
A5US97_ROSS1/783-872KM.DG..TLRSVTV-------------
D3Q8U1_STANL/765-853RG.EA..DPHVVVV-------------
Q8ZXG0_PYRAE/721-807R..GG..EVKAFTV-------------
E8WXR8_GRATM/803-890TG.SA..PARDITI-------------
D2AWH2_STRRD/739-825R..GQ..DKRTFNV-------------
Q020G3_SOLUE/804-893SD.AAGANAREITV-------------
B0VF46_CLOAI/747-837SP.DN.KEEKVVTI-------------
A9BIW8_PETMO/751-841SS.DNIDHKRKYVV-------------
B3QU45_CHLT3/747-837NA.KK.ENMRRVRI-------------
D9QMJ3_BRESC/796-884AS.SG.ANGRDVTV-------------
C6WJJ9_ACTMD/754-843PGGDG..DPRRVVV-------------
E4NAZ7_KITSK/757-844GA.DG..AERHPVV-------------
C7Q5E5_CATAD/793-881TQ.SG..KRTVVVV-------------
E4RW77_LEAB4/768-855DK.PSLEGAKRAIV-------------
C1N9P1_MICPC/828-915RG.D....VVSVRV-------------
D2ARY8_STRRD/732-815G.......GRRVVV-------------
B5GPX5_STRC2/828-913TD.DG..GARRVAV-------------
B5HKU3_9ACTN/746-831PA.EG..EGRSRRV-------------
E4NBJ1_KITSK/740-825H..EN..RIRRIAV-------------
A6KZI1_BACV8/751-841RT.ASSKGVRKVVI-------------
A6LFH5_PARD8/757-847SK.PQLAGARKIVV-------------
F3Z9P9_9ACTN/761-850PA.DG.GEPRHVVV-------------
F3ZGH8_9ACTN/873-959ST.TG.GPPRRVAV-------------
TRI_SULSO/773-858TA.DG..KNKRVTV-------------
Q5LCE8_BACFN/758-848PQ.LS..GARKVVI-------------
V4IJ74_9ACTN/752-841PA.GG.GDPRHTVV-------------
V4J1V6_9ACTN/791-877AA.EG.GRSRRVAV-------------

PF04495

Q2LYW0_DROPS/69-205TAWGGE...GALGCGIGFGYLHRIPVQ
Q0U7P0_PHANO/83-216RGWGGE...GALGCVLGFGALHRIPPS
Q6BX19_DEBHA/130-306RSWGTGQNRGILGCDVGYGLLHRIPEV
A5DBW3_PICGU/154-329RSWGTGHNKGVLGCDVGYGLLHRIPEV
GORS2_MOUSE/69-205SAWGGE...GSLGCGIGYGYLHRIPTR
Q0IEU2_AEDAE/69-205DKWGGE...GSLGCGIGYGYLHRIPIR
Q5KDT5_CRYNJ/68-205RQWGGE...GLIGCGIGYGLLHRIPRP
YAT2_SCHPO/80-213RHWGGN...GAIGCGVGHGVLHRLPAP
GORS1_MOUSE/68-204AAWGGE...GSLGCGIGYGYLHRIPTQ
Q4UCI6_THEAN/70-205ENWGGR...GTLGCDLAKGYIHRIPYV
Q54C46_DICDI/73-210KNWGGS...GSLGCDIGFGLLHRIPTK
Q2UN33_ASPOR/80-214RGWGGE...GALGAELGYGALHRLPVG
A7ARE9_BABBO/70-205HGWGGS...GTLGCDLANGYIHRIPLV
Q4Q3U9_LEIMA/103-265.EMGTNP.EAAVGISVATGLLHIIPSV
Q22G20_TETTS/89-227MNWGGR...GLIGCEFGGGYLNQLPVI
Q386P4_TRYB2/73-244.DFGNDI.YAPLGMNLATGLLHLIPSP
A0A0D1CDK1_USTMA/83-237REWGGE...GLLGCGVGYGLLHRIPKP
Q2HFQ7_CHAGB/78-211RDWGGE...GALGCVLGYGALHRLPAP
B0S774_DANRE/70-205GAWGGE...GSLGCGIGYGYLHRIPA.
E7KBH0_YEASA/142-281.HIGPD...GRLGCNVGYGFLHRIPT.

PF12812

NM111_ASHGO/373-450---------------------------
B8MUN1_TALSN/264-341---------------------------
NM111_PICST/379-456---------------------------
NM111_PICGU/388-465---------------------------
NM111_LODEL/379-456---------------------------
C5MEA8_CANTT/370-447---------------------------
NM111_CANGA/374-451---------------------------
NM111_KLULA/388-465---------------------------
C4R214_PICPG/366-443---------------------------
NM111_YARLI/360-439---------------------------
B6JWG1_SCHJY/372-448---------------------------
B2WNT3_PYRTR/845-923---------------------------
C4Y709_CLAL4/134-212---------------------------
NM111_KLULA/861-937---------------------------
Q6CHS4_YARLI/371-442---------------------------
B6QC43_PENMQ/337-413---------------------------
A9RQ61_PHYPA/347-422---------------------------
A8JH35_CHLRE/368-444---------------------------
C1EGI7_MICSR/349-424---------------------------
C1N456_MICPC/359-434---------------------------
YH05_SCHPO/393-469---------------------------
B8FNF0_DESAA/337-420---------------------------
NM111_MAGO7/393-469---------------------------
B2ASP9_PODAN/396-472---------------------------
B2WNT3_PYRTR/372-451---------------------------
C0NX23_AJECG/394-470---------------------------
B6HPJ1_PENCW/491-567---------------------------
B6K3R7_SCHJY/399-475---------------------------
NM111_YEAST/392-469---------------------------
Q5A946_CANAL/376-453---------------------------
Q6ZIR2_ORYSJ/179-252---------------------------
Q7MWL5_PORGI/399-469---------------------------

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (C,A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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