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455  structures 8741  species 17  interactions 45905  sequences 569  architectures

Clan: Cyclophil-like (CL0475)


Cyclophilin-like superfamily Add an annotation

This superfamily is characterised by being the core, closed, beta barrel of cyclophilin with complex topology, with some family members lacking the N-terminal strand of cyclophilin but retaining a closed barrel.

This clan contains 7 families and the total number of domains in the clan is 45905. The clan was built by P Coggill.


This clan contains the following 7 member families:

CT_A_B CT_C_D Cyclophil_like Cyclophil_like2 DUF3830 DUF871 Pro_isomerase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Pro_isomerase (PF00160) 32385 (70.5%) View
CT_A_B (PF02626) 5336 (11.6%) View
CT_C_D (PF02682) 5285 (11.5%) View
Cyclophil_like2 (PF18050) 1022 (2.2%) View
DUF871 (PF05913) 929 (2.0%) View
DUF3830 (PF12903) 627 (1.4%) View
Cyclophil_like (PF04126) 321 (0.7%) View
Total: 7 Total: 45905 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 17 interactions for this clan. More...

Interacting families
Biotin_carb_C CT_A_B
CT_A_B Biotin_lipoyl
CT_C_D Biotin_lipoyl
Cyclophil_like Cyclophil_like
DUF3830 DUF3830
EF-hand_5 Pro_isomerase
EF-hand_7 Pro_isomerase
Metallophos Pro_isomerase
Pro_isomerase EF-hand_7


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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