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67  structures 4747  species 0  interactions 17160  sequences 139  architectures

Clan: TRD (CL0477)


DNA methylase specificity domain Add an annotation

This superfamily includes domains that are found associated with restriction modification methylase enzymes. These domains are involved in defining the DNA substrate specificity.

This clan contains 3 families and the total number of domains in the clan is 17160. The clan was built by A Bateman.


This clan contains the following 3 member families:

Methylase_S TaqI_C Type_ISP_C

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Methylase_S (PF01420) 14609 (85.1%) View
Type_ISP_C (PF18135) 1312 (7.6%) View
TaqI_C (PF12950) 1239 (7.2%) View
Total: 3 Total: 17160 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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