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32  structures 1652  species 2  interactions 2776  sequences 18  architectures

Clan: PreATP-grasp (CL0483)


Probable substrate-binding preceding ATP-grasp domain Add an annotation

This superfamily is characterised by bein g the copies of the domain that precedes the ATP-grasp domain common to all superfamily members, and it can contain a substrate-binding function.

This clan contains 2 families and the total number of domains in the clan is 2776. The clan was built by P Coggill.

Literature references

  1. Pai CH, Chiang BY, Ko TP, Chou CC, Chong CM, Yen FJ, Chen S, Coward JK, Wang AH, Lin CH;, EMBO J. 2006;25:5970-5982.: Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase. PUBMED:17124497 EPMC:17124497


This clan contains the following 2 member families:

GSH_synthase GSP_synth

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GSP_synth (PF03738) 2307 (83.1%) View
GSH_synthase (PF03199) 469 (16.9%) View
Total: 2 Total: 2776 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 2 interactions for this clan. More...

Interacting families
GSH_synthase GSH_synth_ATP
GSP_synth CHAP


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...