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295  structures 19904  species 22  interactions 93002  sequences 213  architectures

Clan: PreATP-grasp (CL0483)

Summary

Probable substrate-binding preceding ATP-grasp domain Add an annotation

This superfamily is characterised by bein g the copies of the domain that precedes the ATP-grasp domain common to all superfamily members, and it can contain a substrate-binding function.

This clan contains 7 families and the total number of domains in the clan is 93002. The clan was built by P Coggill.

Literature references

  1. Pai CH, Chiang BY, Ko TP, Chou CC, Chong CM, Yen FJ, Chen S, Coward JK, Wang AH, Lin CH;, EMBO J. 2006;25:5970-5982.: Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase. PUBMED:17124497 EPMC:17124497

Members

This clan contains the following 7 member families:

CPSase_L_chain Dala_Dala_lig_N DUF1246 GARS_N GSH_synth_ATP GSH_synthase Synapsin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CPSase_L_chain (PF00289) 47110 (50.7%) View
Dala_Dala_lig_N (PF01820) 24281 (26.1%) View
GARS_N (PF02844) 19160 (20.6%) View
GSH_synth_ATP (PF03917) 964 (1.0%) View
GSH_synthase (PF03199) 848 (0.9%) View
Synapsin (PF02078) 353 (0.4%) View
DUF1246 (PF06849) 286 (0.3%) View
Total: 7 Total: 93002 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 22 interactions for this clan. More...

Interacting families
A B
Biotin_carb_C CPSase_L_chain
CPSase_L_chain Biotin_carb_C
Biotin_lipoyl
CPSase_L_chain
CPSase_L_D2
PYC_OADA
CPSase_L_D2 CPSase_L_chain
CPSase_L_D3 CPSase_L_chain
Dala_Dala_lig_C Dala_Dala_lig_N
Dala_Dala_lig_N Dala_Dala_lig_C
Dala_Dala_lig_N
DUF1246 DUF1297
DUF1297 DUF1246
GARS_N GARS_A
GARS_C
GARS_N
GSH_synth_ATP GSH_synth_ATP
GSH_synthase
PYC_OADA CPSase_L_chain
Synapsin Synapsin
Synapsin_C
Synapsin_C Synapsin

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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