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335  structures 5104  species 22  interactions 24377  sequences 270  architectures

Clan: PreATP-grasp (CL0483)


Probable substrate-binding preceding ATP-grasp domain Add an annotation

This superfamily is characterised by bein g the copies of the domain that precedes the ATP-grasp domain common to all superfamily members, and it can contain a substrate-binding function.

This clan contains 7 families and the total number of domains in the clan is 24377. The clan was built by P Coggill.

Literature references

  1. Pai CH, Chiang BY, Ko TP, Chou CC, Chong CM, Yen FJ, Chen S, Coward JK, Wang AH, Lin CH;, EMBO J. 2006;25:5970-5982.: Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase. PUBMED:17124497 EPMC:17124497


This clan contains the following 7 member families:

Biotin_carb_N Dala_Dala_lig_N DUF1246 GARS_N GSH_synth_ATP GSH_synthase Synapsin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Biotin_carb_N (PF00289) 11985 (49.2%) View
Dala_Dala_lig_N (PF01820) 4863 (19.9%) View
GARS_N (PF02844) 4615 (18.9%) View
GSH_synth_ATP (PF03917) 1235 (5.1%) View
GSH_synthase (PF03199) 1047 (4.3%) View
Synapsin (PF02078) 386 (1.6%) View
DUF1246 (PF06849) 246 (1.0%) View
Total: 7 Total: 24377 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 22 interactions for this clan. More...

Interacting families
Biotin_carb_C Biotin_carb_N
Biotin_carb_N Biotin_carb_C
CPSase_L_D2 Biotin_carb_N
CPSase_L_D3 Biotin_carb_N
Dala_Dala_lig_C Dala_Dala_lig_N
Dala_Dala_lig_N Dala_Dala_lig_C
DUF1246 DUF1297
DUF1297 DUF1246
GSH_synth_ATP GSH_synth_ATP
PYC_OADA Biotin_carb_N
Synapsin Synapsin
Synapsin_C Synapsin


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...