Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
374  structures 20177  species 27  interactions 132217  sequences 358  architectures

Clan: FKBP (CL0487)

Summary

FKBP-like superfamily Add an annotation

This superfamily includes the FKBP domain which catalyses the peptidyl-prolyl cis-trans isomerisation reaction. The superfamily also includes the C-terminal domain of GreA and the c-terminal dmoain of 3-mercaptopyruvate sulfurtransferase.

This clan contains 6 families and the total number of domains in the clan is 132217. The clan was built by A Bateman.

Members

This clan contains the following 6 member families:

DUF1930 FKBP_C GreA_GreB Rotamase Rotamase_2 Rotamase_3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...

Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
FKBP_C (PF00254) 54773 (41.4%) View
GreA_GreB (PF01272) 33039 (25.0%) View
Rotamase (PF00639) 17635 (13.3%) View
Rotamase_3 (PF13616) 16398 (12.4%) View
Rotamase_2 (PF13145) 10354 (7.8%) View
DUF1930 (PF09122) 18 (0.0%) View
Total: 6 Total: 132217 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls

Hide

This tree shows the occurrence of the domains in this clan across different species. More...

Loading...

Interactions

There are 27 interactions for this clan. More...

Interacting families
A B
EF-hand_7 FKBP_C
FKBP_C EF-hand_7
FKBP_C
Pkinase
Rapamycin_bind
TGF_beta_GS
TPR_1
TPR_11
Trigger_C
FKBP_N FKBP_C
GreA_GreB GreA_GreB
GreA_GreB_N
Rnk_N
GreA_GreB_N GreA_GreB
Metallophos FKBP_C
Pkinase FKBP_C
Rad60-SLD FKBP_C
Rhodanese DUF1930
RNA_pol_Rpb1_4 GreA_GreB
RNA_pol_Rpb2_2 GreA_GreB
Rnk_N GreA_GreB
Rotamase Rotamase
SurA_N
SurA_N Rotamase
TGF_beta_GS FKBP_C
TPR_1 FKBP_C
WW Rotamase

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...