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862  structures 9014  species 0  interactions 91467  sequences 862  architectures

Clan: FKBP (CL0487)

Summary

FKBP-like superfamily Add an annotation

This superfamily includes the FKBP domain which catalyses the peptidyl-prolyl cis-trans isomerisation reaction. The superfamily also includes the C-terminal domain of GreA and the c-terminal dmoain of 3-mercaptopyruvate sulfurtransferase.

This clan contains 11 families and the total number of domains in the clan is 91467. The clan was built by A Bateman.

Members

This clan contains the following 11 member families:

DUF1930 DUF4827 FKBP26_C FKBP_C FKBP_N_2 GCD14_N GreA_GreB OSR1_C Rotamase Rotamase_2 Rotamase_3

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
FKBP_C (PF00254) 47055 (51.4%) View
GreA_GreB (PF01272) 13289 (14.5%) View
Rotamase_3 (PF13616) 10763 (11.8%) View
Rotamase (PF00639) 8960 (9.8%) View
OSR1_C (PF12202) 5225 (5.7%) View
Rotamase_2 (PF13145) 4257 (4.7%) View
GCD14_N (PF14801) 1535 (1.7%) View
DUF4827 (PF16109) 171 (0.2%) View
FKBP_N_2 (PF18023) 107 (0.1%) View
FKBP26_C (PF18046) 86 (0.1%) View
DUF1930 (PF09122) 19 (0.0%) View
Total: 11 Total: 91467 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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