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19  structures 1107  species 1  interaction 7323  sequences 127  architectures

Clan: GOLD-like (CL0521)


Sec14-like superfamily of golgi trafficking Add an annotation

This superfamily is characterised by proteins with a sandwich structure of 8 strands in 2 sheets as a jelly-roll. The structure has similarity to the Nucleoplasmin-like/VP fold. The members are all involved in golgi trafficking.

This clan contains 2 families and the total number of domains in the clan is 7323. The clan was built by P Coggill.

Literature references

  1. Anantharaman V, Aravind L; , Genome Biol 2002;3:research0023.: The GOLD domain, a novel protein module involved in Golgi function and secretion. PUBMED:12049664 EPMC:12049664
  2. Mousley CJ, Tyeryar KR, Vincent-Pope P, Bankaitis VA;, Biochim Biophys Acta. 2007;1771:727-736.: The Sec14-superfamily and the regulatory interface between phospholipid metabolism and membrane trafficking. PUBMED:17512778 EPMC:17512778


This clan contains the following 2 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
EMP24_GP25L (PF01105) 6760 (92.3%) View
GOLD_2 (PF13897) 563 (7.7%) View
Total: 2 Total: 7323 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There is 1 interaction for this clan. More...

Interacting families


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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