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264  structures 4674  species 8  interactions 28459  sequences 635  architectures

Clan: DNase_I-like (CL0530)


DNase I-like Add an annotation

This superfamily is characterised by members with an alpha-beta four-layer sandwich structure. It includes DNase I-like families of DNA-repair enzyme exonuclease III, DNA repair endonucleases, deoxyribonuclease I, endonuclease domain of retro-transposons. It also includes families of inositol polyphosphatases and shingomyelins-phosphodiesterases.

This clan contains 2 families and the total number of domains in the clan is 28459. The clan was built by P Coggill.


This clan contains the following 2 member families:

Exo_endo_phos Exo_endo_phos_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Exo_endo_phos (PF03372) 24141 (84.8%) View
Exo_endo_phos_2 (PF14529) 4318 (15.2%) View
Total: 2 Total: 28459 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 8 interactions for this clan. More...

Interacting families
Actin Exo_endo_phos
CDtoxinA Exo_endo_phos
Exo_endo_phos Actin
Exo_endo_phos_2 Exo_endo_phos_2
Thioredoxin Exo_endo_phos


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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