Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
497  structures 20030  species 12  interactions 170836  sequences 186  architectures

Clan: PRTase-like (CL0533)


PRPP synthetase-associated protein 1 Add an annotation

This superfamily of phosphoribosyl-transferases (PRTases) and phosphoribosyl-pyrophosphate synthetase-like protein families is characterised by a core fold of three layers, a/b/a with a mixed beta-sheet of six strands. In one of the families consists of two domains of this fold.

This clan contains 6 families and the total number of domains in the clan is 170836. The clan was built by P Coggill.


This clan contains the following 6 member families:

Pribosyl_synth Pribosyltran PRTase_1 PRTase_2 PRTase_3 UPRTase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Pribosyltran (PF00156) 125306 (73.3%) View
Pribosyl_synth (PF14572) 22659 (13.3%) View
UPRTase (PF14681) 19809 (11.6%) View
PRTase_1 (PF11202) 1502 (0.9%) View
PRTase_2 (PF15609) 1474 (0.9%) View
PRTase_3 (PF15610) 86 (0.1%) View
Total: 6 Total: 170836 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 12 interactions for this clan. More...

Interacting families
GATase_2 Pribosyltran
OMPdecase Pribosyltran
Pribosyl_synth Pribosyl_synth
Pribosyltran GATase_2
Pribosyltran_N Pribosyl_synth
PuR_N Pribosyltran


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...