Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
505  structures 5095  species 20  interactions 69204  sequences 560  architectures

Clan: HEXAPEP (CL0536)


Hexapeptide repeat superfamily Add an annotation

This superfamily is characterised by superhelical turns made up of three short strands duplicated many times; the sequence hexapeptide repeats correspond to individual strands. These hexapeptide repeat regions occur in a range of transferase enzymes.

This clan contains 4 families and the total number of domains in the clan is 69204. The clan was built by P Coggill.

Literature references

  1. Vaara M;, FEMS Microbiol Lett. 1992;76:249-254.: Eight bacterial proteins, including UDP-N-acetylglucosamine acyltransferase (LpxA) and three other transferases of Escherichia coli, consist of a six-residue periodicity theme. PUBMED:1427014 EPMC:1427014


This clan contains the following 4 member families:

DUF4954 Fucokinase Hexapep Hexapep_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Hexapep (PF00132) 59927 (86.6%) View
Hexapep_2 (PF14602) 8643 (12.5%) View
Fucokinase (PF07959) 416 (0.6%) View
DUF4954 (PF16314) 218 (0.3%) View
Total: 4 Total: 69204 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 20 interactions for this clan. More...

Interacting families
Acetyltransf_11 Hexapep
DapH_N Hexapep
Hexapep Acetyltransf_11
Hexapep_2 Hexapep
LpxD Hexapep
Mac Hexapep
NTP_transf_3 Hexapep
NTP_transferase Hexapep
SATase_N Hexapep
THDPS_N Hexapep_2
THDPS_N_2 Hexapep


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...