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14  structures 277  species 3  interactions 2682  sequences 157  architectures

Clan: RAS_GEF_N (CL0542)


Ras guanyl-nucleotide exchange factor activity N-term Add an annotation

This is the more N-terminal domain of the RAS-GEF superfamily.

This clan contains 2 families and the total number of domains in the clan is 2682. The clan was built by P Coggill.


This clan contains the following 2 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RasGEF_N (PF00618) 2431 (90.6%) View
RasGEF_N_2 (PF14663) 251 (9.4%) View
Total: 2 Total: 2682 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
RasGEF_N Ras


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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