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25  structures 507  species 4  interactions 4146  sequences 185  architectures

Clan: RAS_GEF_N (CL0542)

Summary

Ras guanyl-nucleotide exchange factor activity N-term Add an annotation

This is the more N-terminal domain of the RAS-GEF superfamily.

This clan contains 2 families and the total number of domains in the clan is 4146. The clan was built by P Coggill.

Members

This clan contains the following 2 member families:

RasGEF_N RasGEF_N_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RasGEF_N (PF00618) 3657 (88.2%) View
RasGEF_N_2 (PF14663) 489 (11.8%) View
Total: 2 Total: 4146 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 4 interactions for this clan. More...

Interacting families
A B
cNMP_binding RasGEF_N
Ras RasGEF_N
RasGEF_N RasGEF
RhoGEF RasGEF_N

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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