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166  structures 272  species 14  interactions 4311  sequences 179  architectures

Clan: GF_recep_C-rich (CL0547)

Summary

Growth factor receptor Cys-rich Add an annotation

The cysteine-rich regions of growth factor receptor tyrosine kinases consist of eight disulphide-linked modules [1].

This clan contains 5 families and the total number of domains in the clan is 4311. The clan was built by R Eberhardt.

Literature references

  1. Garrett TP, McKern NM, Lou M, Frenkel MJ, Bentley JD, Lovrecz GO, Elleman TC, Cosgrove LJ, Ward CW; , Nature 1998;394:395-399.: Crystal structure of the first three domains of the type-1 insulin-like growth factor receptor. PUBMED:9690478 EPMC:9690478

Members

This clan contains the following 5 member families:

amfpi-1 Furin-like Furin-like_2 GF_recep_IV IGFBP

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
IGFBP (PF00219) 1505 (34.9%) View
Furin-like (PF00757) 1146 (26.6%) View
GF_recep_IV (PF14843) 1070 (24.8%) View
Furin-like_2 (PF15913) 581 (13.5%) View
amfpi-1 (PF12190) 9 (0.2%) View
Total: 5 Total: 4311 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 14 interactions for this clan. More...

Interacting families
A B
Furin-like Furin-like
GF_recep_IV
Recep_L_domain
V-set
GF_recep_IV B
GF_recep_IV
IGFBP Insulin
Kazal_2
Thyroglobulin_1
Insulin IGFBP
Recep_L_domain Furin-like
GF_recep_IV
Thyroglobulin_1 IGFBP
V-set Furin-like

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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