Sequence alignment for CL0547

PF14843

F2U6Q9_SALR5/180-312----PCSSLCNGA.--------------------CWGPGD------HQCLSCADSAVAIVQAQAGVVHVTCADT.CP...
A8WPC3_CAEBR/574-697----VCDPNCNKRG--------------------CWGKRP------NDCLECRTWNNM..........GSCVSK.CDTVG
E3NFJ5_CAERE/507-626----ICDPNCNSRG--------------------CWGKQP------EDCLECRTWNNM..........GTCVSSQCDIGY
Q23821_CAERE/560-683----ICDPNCNSRG--------------------CWGKRP------EDCRECRTWNNM..........GTCVSK.CDTIG
Q4RG29_TETNG/491-621----VCHRLCKGG.--------------------CWGPGP------GQCASCETFQRG..........TECVEH.CDIYQ
Q923V5_RAT/34-167----VCNSLCAHGH--------------------CWGPGP------TQCVNCSHFLRG..........QECVEE.CRVWK
Q153D8_XENLA/509-641----KCFSRCAGEQ--------------------CWGPGP------SQCVRCNGFLRG..........HDCIES.CNIQD
F1QYI3_DANRE/475-607----ICDPLCSEAG--------------------CWGPGP------DQCLSCKYFSRG..........KTCVKS.CNLYY
F1M7X4_RAT/475-607----VCNHLCSNDG--------------------CWGPGP------DQCLSCRRFSRG..........KICIES.CNLYD
Q153D9_XENLA/519-651----VCDPFCSNIG--------------------CWGPGA------NQCLSCRYFSRG..........KSCVRS.CNLCK
ERBB3_RAT/499-630----VCDPLCSSGG--------------------CWGPGP------GQCLSCRNYSRE..........GVCVTH.CNFLQ
Q2HZD7_CHICK/500-631----VCDPLCSADG--------------------CWGPGP------AQCLSCRHYSRR..........GVCVES.CSFTQ
E9QC99_DANRE/495-628----VCDPLCSDAG--------------------CWGPGP------EQCLSCRNYSRL..........GTCVSH.CNLYS
P79754_TAKRU/494-627----VCDPLCSDSG--------------------CWGPGP------DQCLSCRNYSRH..........GTCVAG.CHFNS
Q9YH40_XIPXI/501-633----TCNNECSEDG--------------------CWGPGP------TMCVSCLHVDRG..........GRCVAS.CNLLQ
Q6VQA3_DANRE/503-635----TCNEMCTADD--------------------CWGPGP------TMCFSCEHYSRG..........KHCVAS.CNLLN
Q4RWY4_TETNG/474-606----ICDRKCTAEG--------------------CWGPGP------DMCFTCSDYSRG..........GSCVDS.CNILE
Q153D7_XENLA/91-223----VCDTLCSEEG--------------------CWGPGP------SQCVSCLKYIRG..........KECVEN.CNFLS
E7CXR8_RAT/505-637----VCNPLCSSEG--------------------CWGPEP------TDCVSCQNVSRG..........RECVDK.CNILE
A5A753_PIG/500-632----ICNPLCSSEG--------------------CWGPEP------RDCMSCRNFSRG..........KECVEK.CNVLE
D0RB24_NOTVI/501-633----ICDLLCSDNG--------------------CWGPGP------FSCLSCRYFLRM..........TECVET.CNIMK
E1C0S3_CHICK/515-650----VCDPLCSDVG--------------------CWGPGP------FHCFSCRFFSRQ..........KECVKQ.CNILQ
Q9BIH9_ANOGA/471-584----ECSEQCSKAG--------------------CWGKGP------EQCLECKNVKYK..........GKCLDS.CKSL.
X1XZ97_ANODA/494-602----QCSEQCTTAG--------------------CWGKGP------EQCLECKNFVYE..........GKCLDS.CKSL.
Q6SAX4_DROME/471-583----ICSDQCNEDG--------------------CWGAGT------DQCLTCKNFNFN..........GTCIAD.CGYI.
B4LLF8_DROVI/581-693----VCSDQCNSDG--------------------CWGAGP------DQCLNCKSFNYN..........GTCIAD.CRNV.
B3MC66_DROAN/584-696----VCSDQCNEDG--------------------CWGAGP------DQCLNCKNFNYS..........GTCIAD.CRNI.
E0W212_PEDHC/466-580----VCDPQCSSEG--------------------CWGPGP------KQCISCINFKNG..........NECVQD.CNSIK
E2CA29_HARSA/483-596----VCNEECSDEG--------------------CWGPGP------AQCLSCKNVKLG..........NDCLQD.CTA..

PF00757

INSR_HUMAN/179-340--NEECGDICPGTA.KGKTNCPATVINGQFVER.CWTHS........HCQ..................KVCPTI-CKS.H
Q1LVG4_DANRE/171-332--DLECGNICPGTI.AGTISCKQTT.INGNFGERCWNQN........HCQ..................RICPSE-CVH.G
INSR_AEDAE/196-357--NGSKQKCPAAPV.RGGNKDH.......KRTL.CWNAN........HCQ..................TICPPE-CPK..
Q4RG29_TETNG/162-318--AQNCP.........NCSSQC.......LTS..CWGEAA......QDCQTL..............TRSNCASG-CQ...
Q2HZD7_CHICK/183-335--GRACA.........PCHESC.......GGH..CWGPGP......EDCQQL..............TKTICAPQ-CNG..
Q6SAA1_DROME/154-303--ERECP.........KCHESC.......THG..CWGEGP......KNCQKF..............SKLTCSPQ-CAG.G
Q9W6F6_CHICK/31-183--SSGCG.........RCHKSC.......TGR..CWGPTE......NHCQTL..............TKTVCAEQ-CDG..
O93457_PSEMX/181-336--SKECSDVCPGIM.ENNPQCRKTM.FNSNYNYRCWNSN........KCQ..................KECPER-CAR.Q
Q6QMR8_DANRE/182-336--GKNCG.........KCDPSC.......FNGS.CWGTGP......DKCQRM..............TKVIYAER-CSG..
ILPR_BRALA/178-321--EEECVNFCPGRC.RIKHPVLQ....DL.....CWAEE........HCQ..................KVCPES-CLG..
IGF1R_XENLA/172-329--PKECVDLCPGAR.EKMQICEKSS.INNEFADRCWSDE........HCQ..................KVCPSV-CGK.R
Q4S8B8_TETNG/198-353--SKECSDVCPGVM.ESSPQCRKTV.FNNNYSYRCWNSN........HCQ..................RECPDK-CGR.R
Q4RUB0_TETNG/145-331--DRECGDVCPGTA.QGQTICPQNT.INGHFRGRCWSQN........HCQRTGLPVGKSGLKGCTMCLRVCGEN-CKH.S
Q2EJ72_CHICK/180-332--SRTCP.........DCRALC.......AEGH.CWGESP......QDCQTL..............TNSIC.HG-CP...
A2IRM8_CYNPY/177-334--PKECGDLCPGAM.EAKPLCEKTS.INYEYSRRCWSAN........HCQ..................KVCPPE-CGK.G
Q4RWY4_TETNG/154-308--NPQCQ.........KCHSSC.......FNGS.CWAPGS......QNCQQL..............TKLNCAQQ-CSR..
Q9YH40_XIPXI/187-340--ERQCQ.........KCDPGC.......VNGS.CWAPGP......GHCQKF..............TKLLCAEQ-CNR..
INSRR_HUMAN/173-329--GEECADVCPGVLGAAGEPCAKTT.FSGHTDYRCWTSS........HCQ..................RVCP..-CPHGM
Q1LWJ4_DANRE/181-336--SKECGDVCPGIN.EDRPHCIRTS.FNDNYSYRCWTSN........HCQ..................KVCPKE-CEK.R
Q6PA47_XENLA/176-333--VEECSDVCPGIR.DFGESCVKTP.INGNVESRCWTST........SCQ..................KVC..N-CGKDI
ERBB2_CANFA/189-343--FSACP.........PCSPAC.......KDAH.CWGASS......GDCQSL..............TRTVCAGG-CA...
Q8MIL8_PIG/184-338--LGSCP.........KCDPGC.......LNGS.CWGAGK......ENCQKL..............TKVICAQQ-CSG..
Q4H3N3_CIOIN/233-394--DRYCD.........PCPSVCRDD.SGSTPVNRCWGNSS......DLCQLI..............TKSKCRRQ-CGN.D
Q8UW85_PAROL/178-344--DRECGDVCPGAA.LGKTTCQTTT.INGHFSERCWTQK........HCQ..................KMCPVQ-CKH.R
Q9NJV5_BIOGL/183-333--SKQPCPVCRSNC.EPRN...............CWSYD........QCQ..................KGFTCS-CKANQ
Q4REV4_TETNG/149-304--PEECDNVCPGIMVKDEPLCQRTS.FNDNHDARCWTSN........HCQ..................KVCPER-CKL..
INSR_XENLA/189-350--KEECGDVCPGTV.KGKSKCKHTL.VNGALVERCWTQD........HCQ..................KVCPSD-CKG.S
MIPR_LYMST/206-359--KEQCPNSCKDEC.QSKR...............CWTYS........DCQ..................KGLNCQ-CKENT
Q86MD7_ECHMU/215-366--NTTCHSACSEND.EKGH...............CWGPEK......NQCQL................RSKCTKE-STT..
P79754_TAKRU/177-329--NGERG.........VCHKSC.......GNY..CWGPGK......DQCQIL..............TKTVCAPQ-CND..
Q8UW84_PAROL/181-335--AKECDNVCPGIM.EDNPLCKRTL.FNDNYDYRCWTST........QCQ..................KVCPEH-CKF..
Q5EBY4_DANRE/181-338--PKNCP.........RCSSAC.......KSGG.CWGEKD......QDCQTL..............TSVNCSSG-CS...
LET23_CAEEL/214-369--GKSMA.........KCHESC........NDK.CWGSGD......NDCQRV..............YRSVCPKS-CS...
Q153D8_XENLA/183-342--HRQCP.........LCSPACGSL.PSGRSGL.CWGVGQ......EYCQTL..............TSTICDSG-CQ...
A6P6W2_COTJA/175-333--PKECGDLCPGTM.EEKPLCEKTS.INNEYNYRCWTTN........HCQ..................KMCPSS-CGK.R
HTK7_HYDVU/189-344--KGHCHPAPGHDG.DPKAQY.............CWGPGPKKQQNKAQCQ..................RFCNTQ-CGP.E
Q17D67_AEDAE/155-304--ERDCP.........PCHSSC.......EVG..CWGEGA......HNCQKF..............SKLNCSPQ-CSQ.G
Q7Q0F6_ANOGA/194-348--LRDVNRLIHNEK.ASHL...............CWSTN........HCQ..................QKCPAH-CPK..
Q4RXV8_TETNG/185-366--NGPEK.........PCHKAC.......GDVP.CWGPGS......DMCQIL..............TKTVCAPQ-CNF..
INSR_DROME/509-648--NASCQLHNNRRL....................CWNSK........LCQ..................TKCPEK-CRN..

PF15913

H9GP38_ANOCA/86-194CDK.GCDLCSEFNG----------------------------------CLRCCPRLFILLERNDIRQTGICLQS-CPS--
RSPO4_HUMAN/35-140C.T.GCIICSEENG----------------------------------CSTCQQRLFLFIRREGIRQYGKCLHD-CPP--
G5AJQ8_HETGA/35-140L.S.FQLSCGSERG----------------------------------CMACQQRLFLLIRREGIRQYGKCVHD-CPL--
H9GGW4_ANOCA/2-111C.T.GCIMCSEDNG----------------------------------CISCQQKLFLIIWRDGMRQYGACVHA-CPP--
G1K3B0_XENTR/36-142C.K.GCLSCSKDNG----------------------------------CLRCQPKLFFYLRREGMRQYGECLQS-CPP--
H3ABT8_LATCH/20-126C.S.SCVRCSGDNG----------------------------------CSTCQKKLFLLIWREGIRQYGACVHS-CPP--
F8W4P8_DANRE/38-142C.R.SCVLCSRENG----------------------------------CLRCSERLFLFLRRDGILHHGSCLHS-CPA--
H2SL31_TAKRU/42-148C.K.GCSMCSRDNG----------------------------------CVNCQPKLFLFLRRERMRQYGECLHD-CPA--
F6USY9_ORNAN/37-145C.QGGCATCSDYNG----------------------------------CLSCKPRLFFVLERIGMKQIGVCLSS-CPS--
H0YTH5_TAEGU/40-149CAR.GCDLCSEFNG----------------------------------CLRCSPKLFILLERNDIRQIGICLPS-CPL--
H2S9X8_TAKRU/44-150Q.G.GCLTCSDYNG----------------------------------CLSCKPRFFMHLERIGMKQIGVCVTS-CPP--
RSPO1_DANRE/41-147C.SNGCEHCSEYNG----------------------------------CLKCRPRLFILLERNDIRQIGICLAA-CPV--
H2MI93_ORYLA/41-153C.PKGCDRCSEYNG----------------------------------CVKCKPKLFIFLERNDIRQVGVCLAS-CPV--
E1BVQ0_CHICK/35-141C.T.GCVLCSEENG----------------------------------CITCHHRLFLLIWRDGIRQYGVCVHT-CPP--
F6T8G8_XENTR/42-147..QGGCATCSDYNG----------------------------------CLTCKPQLFFALVRNGMKQIGVCRPS-CPN--
F7EGR5_XENTR/41-147..K.GCDLCSEFNG----------------------------------CMKCLPKLFILLERNDIRQTGICLQS-CPQ--

PF14843

F2U6Q9_SALR5/180-312..DGTYEDDT-RVCRTCD-AA-C.........ATC------SGPS-STSCGSCVAFA.....DTT----TSTCVSSCPH-
A8WPC3_CAEBR/574-697FLRNQTSM..-.RCQPCS-PE-C.........KTC------NGIG-EFDCLSCRHFTLYNPEFGN----RMECVESCPK-
E3NFJ5_CAERE/507-626FGNQTSMT..-..CEKCS-PE-C.........ETC------NGLG-EFDCLSCRHYTFYNPNFGN----RMECVSDCPT-
Q23821_CAERE/560-683FLRNQTSM..-.KCQKCS-PE-C.........ETC------NGLG-EFDCLSCRHYTLYNSDFGN----RMECVSDCPT-
Q4RG29_TETNG/491-621GSVREYAS.E-SLCVACH-PE-CQPLNGS...ASC------HGPG-AEHCVECRKFQ.......D----GDFCVDHCPS-
Q923V5_RAT/34-167GLPREYVS.D-KRCLPCH-PE-CQPQNSS...ETC------FGSE-ADQCAACAHYK.......D----SSSCVARCPS-
Q153D8_XENLA/509-641GIPREHVN.G-SQCVPCH-SQ-CHPQNGS...LTC------SGPE-ASQCIECAHYM.......D----GEDCVEHCPS-
F1QYI3_DANRE/475-607GDVREFAN.G-SVCVECD-SQ-CEKAGEKG..LTC------HGPG-PDHCVKCLHLK.......D----GPNCVEKCPD-
F1M7X4_RAT/475-607GEFREFEN.G-SICVECD-SQ-CEKMEDGL..LTC------HGPG-PDNCTKCSHFK.......D----GPNCVEKCPD-
Q153D9_XENLA/519-651GESREFAN.G-SVCVKCD-PQ-CEKIDEGM..ATC------YGAG-PDHCTKCSSFK.......D----GPNCVEKCPE-
ERBB3_RAT/499-630GEPREFVH.E-AQCFSCH-PE-CLPMEGT...STC------NGSG-SDACARCAHFR.......D----GPHCVNSCPH-
Q2HZD7_CHICK/500-631GETREFAE.G-TECFECH-PE-CERVEGG...ITC------NGSG-ADTCTRCAHYR.......D----GPHCVERCPE-
E9QC99_DANRE/495-628GEPREFAASN-KECLACH-SE-CLLQNGK...QTC------LGKG-ADQCVACSNLM.......D----GPHCVSSCPN-
P79754_TAKRU/494-627GIPREFAGLN-GVCVACH-PE-CKPQTGK...ASC------TGPG-ADECMACTKFR.......D----GPYCMSSCPA-
Q9YH40_XIPXI/501-633GEPREAQV.D-GRCVQCH-QE-CLVQTDS...LTC------YGPG-PANCSKCAHFQ.......D----GPQCIPRCPH-
Q6VQA3_DANRE/503-635GEPREYEV.N-KTCMECD-PE-CLLMNET...QTC------NGPG-PDKCTVCANYK.......D----GPHCVHRCPQ-
Q4RWY4_TETNG/474-606GESRETVV.N-KTCVKCH-PE-CERMNGT...TTC------SAPG-SGNCTRCANFQ.......D----GLFCVSRCPR-
Q153D7_XENLA/91-223REPRGYTV.D-GRCFSCN-VE-CLQLNDT...QTC------SGPG-ADECFKCAHYS.......D----GPFCVKTCPA-
E7CXR8_RAT/505-637GEPREFVE.N-SECIQCH-PE-CLPQTMN...ITC------TGRG-PDNCIKCAHYV.......D----GPHCVKTCPS-
A5A753_PIG/500-632GEPREFVE.N-AECVQCH-PE-CLPQAKN...VTC------MGRG-PDSCVRCAHYI.......D----GPHCVKTCPA-
D0RB24_NOTVI/501-633GEPREYVK.D-SKCFRCH-PE-CLIQNTT...TTC------TGPG-PDNCLACAHFK.......D----GPHCVKSCPS-
E1C0S3_CHICK/515-650GEPREFER.D-SKCLPCH-SE-CLVQNSTAYNTTC------SGPG-PDHCMKCAHFI.......D----GPHCVKACPA-
Q9BIH9_ANOGA/471-584..PRLYSVDS-KTCGDCH-QE-CK........DFC------YGPN-EDNCGSCMNVK.......D----GRFCVAECPT-
X1XZ97_ANODA/494-602..PRIYQVNS-KTCEDCH-PE-CK........DFC------YGPN-ADNCGSCVNVK.......D----GKFCVSECP.-
Q6SAX4_DROME/471-583..SNAYKFDN-RTCKICH-PE-C.........RTC------NGAG-ADHCQECVHVR.......D----GQHCVSECPK-
B4LLF8_DROVI/581-693..TKTYQFDA-KTCKKCH-PE-C.........RTC------SGPG-AEHCDECVHVR.......D----DQHCVTVCPE-
B3MC66_DROAN/584-696..SNAYRHDS-KTCRICH-EE-C.........KTC------SGPG-AEDCDECVHVR.......D----EQHCVSECPE-
E0W212_PEDHC/466-580GM...YTAGP-NLCKPCH-EE-CA........STC------FGPG-NGNCTKCKHVR.......D----GPFCYSSCPE-
E2CA29_HARSA/483-596..PGIYRADE-KTCKTCH-VE-CD........GSC------TGPN-AEQCTKCKHVR.......D----GPFCVPECPS-

PF00757

INSR_HUMAN/179-340GCT.....AE-GLC--CH.SE-CL--------GNC......SQPDDPTKCVACRNFY-------L....DGRCVETCPP.
Q1LVG4_DANRE/171-332ACT.....SH-KEC--CH.EQ-CL--------GGC......SVPGNSTKCVACRNFL-------Y....GEACVDRCPP.
INSR_AEDAE/196-357ACS.....KT-GVC--CDAES-CL--------GGC......NLPN.TSSCSVCRHLS-------IDPAGKRQCVAKCPP.
Q4RG29_TETNG/162-318RCKG...FLP-NDC--CH.KQ-CA--------AGC......TGPK.DSDCLACRHFN-------D....SGVCKENCPPP
Q2HZD7_CHICK/183-335RCFG...RAP-NEC--CH.EE-CA--------GGC......TGPL.QTHCFACRHFN-------D....SGACVPLCPQP
Q6SAA1_DROME/154-303RCYG...PKP-REC--CH.LF-CA--------GGC......TGPT.QKDCIACKNFF-------D....EGVCKEECPPM
Q9W6F6_CHICK/31-183RCYG...PYV-SDC--CH.RE-CA--------GGC......SGPK.DTDCFACMNFN-------D....SGACVTQCPQT
O93457_PSEMX/181-336ACT.....AD-GEC--CH.PQ-CL--------GSC......TAPGSDTACAACVHYY-------H....QGRCVAECPP.
Q6QMR8_DANRE/182-336RCKG...PRP-IDC--CN.EH-CA--------AGC......TGPR.PTDCLACKDFQ-------D....EGTCKDACPRL
ILPR_BRALA/178-321NCR....DGI-SGC--CH.EN-CI--------GGC......DGPT.ERDCVACKYFV-------H....NGECLIQCPP.
IGF1R_XENLA/172-329ACS.....DN-NEC--CH.PE-CL--------GSC......TAPDNDTACVACHHYF-------Y....EGRCVPTCPS.
Q4S8B8_TETNG/198-353ACT.....AD-GQC--CH.PQ-CL--------GSC......TRAGSDAACAACVHYY-------H....HGRCVAQCPP.
Q4RUB0_TETNG/145-331TCT.....LQ-GQC--CH.DQ-CL--------GGC......SEPGNASSCVACRNLL-------H....ANTCVEKCPP.
Q2EJ72_CHICK/180-332RCKG...TKP-TDC--CH.EQ-CA--------AGC......TGPK.HSDCLACLNFN-------R....SGICELHCPPL
A2IRM8_CYNPY/177-334ACT.....DQ-KQC--CH.AE-CL--------GSC......SMPDNDTACVACRHFF-------Y....EGRCLATCPP.
Q4RWY4_TETNG/154-308RCNG...PAP-SNC--CN.EH-CA--------AGC......TGPR.ATDCLACRDFQ-------D....DGVCKDSCPGL
Q9YH40_XIPXI/187-340RCRG...PKP-IDC--CN.EH-CA--------GGC......TGPR.ATDCLACRDFN-------D....DGTCKDTCPPP
INSRR_HUMAN/173-329ACT.....AR-GEC--CH.TE-CL--------GGC......SQPEDPRACVACRHLY-------F....QGACLWACPP.
Q1LWJ4_DANRE/181-336ACT.....DA-GQC--CH.PQ-CL--------GSC......TEADNDKACAACQHYF-------H....EDRCVEACPP.
Q6PA47_XENLA/176-333ACS.....NT-GEC--CH.SE-CL--------GGC......NKADDPRACVACRNFY-------I....DDQCLASCPR.
ERBB2_CANFA/189-343RCKG...PQP-TDC--CH.EQ-CA--------AGC......TGPK.HSDCLACLHFN-------H....SGICELHCPAL
Q8MIL8_PIG/184-338RCRG...RSP-SDC--CH.NQ-CA--------AGC......TGPR.ESDCLVCRRFR-------D....EATCKDTCPPL
Q4H3N3_CIOIN/233-394RCN.....AG-GAC--CN.GK-CA--------GGCYDNMPATGNK.DKWCHACKDMN-------N....NGTCVEACPQG
Q8UW85_PAROL/178-344ACT.....KD-DQC--CH.DQ-CL--------GGC......LQPNSASHCVACRGLQ-------L....EGNCVDRCPE.
Q9NJV5_BIOGL/183-333GCM.....AN-GAC--CH.EY-CL--------GGC......KGPT.AEDCYSCKYVS-------F....NNSCLSECPP.
Q4REV4_TETNG/149-304ACT.....DQ-GEC--CH.SQ-CL--------GSC......TEPNNDMACSACLHYH-------H....EGRCVQDCPP.
INSR_XENLA/189-350GCL.....PD-GQC--CH.PE-CL--------GSC......RKPNDPSECTACRHFQ-------N....EGVCVTACPK.
MIPR_LYMST/206-359YCM.....EN-GSC--CH.DY-CL--------GGC......KVPMNPDECFSCKEVQ-------F....NNTCRPQCPP.
Q86MD7_ECHMU/215-366YCRLD.NPFE-RIK--CD.DA-CI--------GGC......NGS..TSNCWACRSKR-------N....GDTCVSFCPPR
P79754_TAKRU/177-329RCFG...TSP-RDC--CH.IE-CA--------AGC......KGPL.DTDCFACRLFN-------D....SGACVPQCPQT
Q8UW84_PAROL/181-335ACT.....DK-GEC--CH.SQ-CL--------GTC......TEPNNDMACSACLHYF-------H....EDRCVPDCPL.
Q5EBY4_DANRE/181-338RCKG...PKP-SDC--CH.VQ-CA--------AGC......TGPK.DSDCLACRHFN-------D....SGTCKDSCPPP
LET23_CAEEL/214-369QCFYSNSTSS-YEC--CD.SA-CL--------GGC......TGHG.PKNCIACSKYE-------L....DGICIETCPSR
Q153D8_XENLA/183-342RCKG...NHS-THC--CH.EQ-CA--------AGC......TGPK.NSDCLACLLFN-------H....SGVCGTHCPPL
A6P6W2_COTJA/175-333ACT.....DQ-NEC--CH.PE-CL--------GSC......TAPDNNTACVACRNYY-------Y....EGVCMPTCPP.
HTK7_HYDVU/189-344GCLD...GSD-HIC--CH.HE-CL--------GGC......SAINSTNTCHACRKYR-------IK..STGQCVSKCPR.
Q17D67_AEDAE/155-304RCFG...SKP-REC--CH.LF-CA--------GGC......TGPT.QKDCLACKNFY-------D....DGVCKQECPPM
Q7Q0F6_ANOGA/194-348SCN.....KT-GEC--CS.TS-CL--------GQC......SSNN.KSHCMVCRKYY-------YIHNNQTRCVDKCPD.
Q4RXV8_TETNG/185-366RCFG...RSP-GEC--CH.SE-CA--------GGC......TGPL.DTDCFACRKFN-------D....SGSCVPQCPMA
INSR_DROME/509-648NCI.....DE-HTC--CS.QD-CL--------GGC.....VIDKNGNESCISCRNVS-------F....NNICMDSCPK.

PF15913

H9GP38_ANOCA/86-194GYFGLRNPDM.NKCIKCKIEN.C---------EEC--------------------FS------------RNFCT-KCKE-
RSPO4_HUMAN/35-140GYFGIRGQEV.NRCKKCGA.T.C---------ESC--------------------FS------------QDFCI-RCKR-
G5AJQ8_HETGA/35-140GFFGIRGQEV.NRCKKCGA.T.C---------DSC--------------------FS------------QDFCI-RCKR-
H9GGW4_ANOCA/2-111GYFGVRGQEV.NRCIKCRSPN.C---------ESC--------------------FS------------KDFCI-KCKQ-
G1K3B0_XENTR/36-142GYYGVRGPDM.NRCSRCRIEN.C---------DSC--------------------FS------------RDFCI-KCKS-
H3ABT8_LATCH/20-126GYFGVRGQEV.NRCTKCKTSY.C---------ETC--------------------FS------------KDFCM-RCKE-
F8W4P8_DANRE/38-142GHFGLRGKEL.NRCMKCKA.PEC---------ERC--------------------FN------------KDFCT-KCKI-
H2SL31_TAKRU/42-148GYYGMRSPEL.NMCSRCRIEN.C---------ESC--------------------FS------------KDFCT-KCKS-
F6USY9_ORNAN/37-145GYFGTRYPDI.NKCTKCKA.E.C---------ETC--------------------FT------------RTFCT-KCKN-
H0YTH5_TAEGU/40-149GYFGLRNTDM.NKCIKCKIEN.C---------ESC--------------------FS------------RNFCT-KCKE-
H2S9X8_TAKRU/44-150GFYGTRFPER.SPCTKCRS.E.C---------DSC--------------------FA------------KNFCT-RCRA-
RSPO1_DANRE/41-147GYYGIRNRDM.NKCTQCKIEN.C---------EAC--------------------FS------------RNFCT-KCKE-
H2MI93_ORYLA/41-153GYFGMRNPEGNNRCTQCKIDN.C---------EAC--------------------FN------------RNFCT-KCKE-
E1BVQ0_CHICK/35-141GYFGVRGLEV.NRCTKCRSPS.C---------ESC--------------------FS------------KDFCM-KCKE-
F6T8G8_XENTR/42-147GYFGTRSPEI.NKCTKCKA.D.C---------ETC--------------------FN------------KNFCT-KCKS-
F7EGR5_XENTR/41-147GYFDDRNREN.NRCLKCKINN.C---------ETC--------------------FS------------KNFCT-KCKE-

PF14843

F2U6Q9_SALR5/180-312---------------DAY.ASPTAPV-----------------------------------GFGTT-----APEYCMP-C
A8WPC3_CAEBR/574-697---------------ATY........-----------------------------------..FST-----EDDVCEK-C
E3NFJ5_CAERE/507-626---------------HT.........-----------------------------------.RCST-----IGNVCEK-C
Q23821_CAERE/560-683---------------STH........-----------------------------------..YST-----TKNVCER-C
Q4RG29_TETNG/491-621---------------GVK..EDHQTV-----------------------------------WKYSN-----ATGHCLP-C
Q923V5_RAT/34-167---------------GVKPDLSYMPI-----------------------------------WKYPD-----EEGICQP-C
Q153D8_XENLA/509-641---------------GVK.GSSFVPI-----------------------------------WKFPD-----KDKICQL-C
F1QYI3_DANRE/475-607---------------GLQ.GANS.FI-----------------------------------FKYAE-----TNNECHP-C
F1M7X4_RAT/475-607---------------GLQ.GANS.FI-----------------------------------FKYAD-----QDRECHP-C
Q153D9_XENLA/519-651---------------GLQ.GANS.FI-----------------------------------FKYAD-----EDKECHP-C
ERBB3_RAT/499-630---------------GIL.GAKG.PI-----------------------------------YKYPD-----AQNECRP-C
Q2HZD7_CHICK/500-631---------------GIL.GERG.PI-----------------------------------YKYPD-----SSRECRP-C
E9QC99_DANRE/495-628---------------GVN.GEKGQTI-----------------------------------FKYST-----AAGHCEL-C
P79754_TAKRU/494-627---------------GVNDGEKG.LI-----------------------------------FKFPN-----REGHCEP-C
Q9YH40_XIPXI/501-633---------------GML.GDGDTLI-----------------------------------WKYAD-----KMGQCQP-C
Q6VQA3_DANRE/503-635---------------GVP.GEKDTLI-----------------------------------WKYAD-----VTHVCQP-C
Q4RWY4_TETNG/474-606---------------GVP.GEDDMLV-----------------------------------WKYAD-----NNKVCQL-C
Q153D7_XENLA/91-223---------------GIH.GENNSLI-----------------------------------WKYPD-----ENGACQL-C
E7CXR8_RAT/505-637---------------GIM.GENNTLV-----------------------------------WKFAD-----ANNVCHL-C
A5A753_PIG/500-632---------------GIA.GENSTLI-----------------------------------WKFAD-----ANHVCHL-C
D0RB24_NOTVI/501-633---------------GIM.GENDTYI-----------------------------------WKYAD-----ENKVCQL-C
E1C0S3_CHICK/515-650---------------GVL.GENDTLV-----------------------------------WKYAD-----ANAVCQL-C
Q9BIH9_ANOGA/471-584---------------T..........-----------------------------------.KHAM-----.NGTCIN-C
X1XZ97_ANODA/494-602---------------..........I-----------------------------------MKYAL-----.NGTCVK-C
Q6SAX4_DROME/471-583---------------N..........-----------------------------------.KYND-----.RGVCRE-C
B4LLF8_DROVI/581-693---------------N..........-----------------------------------.KYSD-----.FGICRR-C
B3MC66_DROAN/584-696---------------N..........-----------------------------------.KYSD-----.NGICRK-C
E0W212_PEDHC/466-580---------------T..........-----------------------------------.KYND-----.NGECKS-C
E2CA29_HARSA/483-596---------------S..........-----------------------------------.KYND-----.SGECKH-C

PF00757

INSR_HUMAN/179-340...............PYYHFQDWRCVNFSFCQDLHHK...............CKNSRRQGCHQYVI.....HNNKCIPEC
Q1LVG4_DANRE/171-332...............GYYTFKSWRCVSLQFCQDLHN................QCKDKSGDCHAYVI.....HNGACIPEC
INSR_AEDAE/196-357...............NTFKY.HTRCVTRDECYAMKKPI.............SLDSNPDLPDQPFIP.....HNGSCLMEC
Q4RG29_TETNG/162-318TTYDPATFQSKPNPDRKFSF.GATCV..KTCP............................YNYLAM.....DV.ACTLNY
Q2HZD7_CHICK/183-335LIYNKLTFQLEPNPDTKYQY.GSVCV..RSCP............................HNFVV......DQSSCVRAC
Q6SAA1_DROME/154-303RKYNPTTYVLETNPEGKYAY.GATCV..KECP.............................GHLLR.....DNGACVRSC
Q9W6F6_CHICK/31-183FVYNPTTFQLEHNHNAKYTY.GAFCV..KKCP............................HNFVV......DSSSCVRAC
O93457_PSEMX/181-336...............GTYKFEDWRCISAELCSK......................VHLPEYDSFII.....HGEECMPEC
Q6QMR8_DANRE/182-336MLYDPNTHQLAPNPYGKYSF.GATCI..KTCP............................HNYVVT.....DHGACVRTC
ILPR_BRALA/178-321...............DTYQYKDRRCITEEECP.........................NTTNSVWKL.....HHRKCIPEC
IGF1R_XENLA/172-329...............NTYKFEGWRCITREVCAKM....................HIWIHSTIPFII.....HKGECVYEC
Q4S8B8_TETNG/198-353...............GTYRFEGWRCVSVDFCSK......................VHLPDPHTFVL.....HGQECMPEC
Q4RUB0_TETNG/145-331...............GYFIFRGWRCVSFSFCQELHNQCKQ.........IKKLNQDIEPGCSEYVI.....HDGACIPEC
Q2EJ72_CHICK/180-332VIYNSDTFESVPNRDGRYTF.GASCV..SQCP............................YNYLAT.....EVGSCTLVC
A2IRM8_CYNPY/177-334...............HTYMFEGWRCVSREFCARV....................PSSDTDYEPYVI.....HKGECMPEC
Q4RWY4_TETNG/154-308IRYDPNLHQLVPNPHGKYNF.GAKCV..KTCP............................HNYVVT.....DHGACVRTC
Q9YH40_XIPXI/187-340KIYDIVSHQVVDNPNIKYTF.GAACV..KECP............................SNYVVT.....E.GACVRSC
INSRR_HUMAN/173-329...............GTYQYESWRCVTAERCASL....................HSVPGRASTFGI.....HQGSCLAQC
Q1LWJ4_DANRE/181-336...............DTYKFEGWRCITMEMCAR......................VHLPSEVDFVI.....HNGECMPDC
Q6PA47_XENLA/176-333...............GTYEYEGWRCIKKAYCSNLRK.................ESENSQESTKFVI.....FENRCLSEC
ERBB2_CANFA/189-343VTYNTDTFESMPNPEGRYTF.GASCV..TSCP............................YNYLST.....DVGSCTLVC
Q8MIL8_PIG/184-338MLYNPTTYQMDVNPLGKYSF.GATCV..KKCP............................RNYVVT.....DHGSCVRAC
Q4H3N3_CIOIN/233-394TQMNPT..STITKTPKTYQF.ARYCV..PKCP.............................FNVPQ.....TTSFCRTYC
Q8UW85_PAROL/178-344...............NHFTFKGWRCVTFAFCQDLHNKCK...........REKERAKNPDCHEYVI.....HNGACVADC
Q9NJV5_BIOGL/183-333...............ATYRYKGRRCLTDRECLSL.....................PYQSGKAPMLLVGEKGEPSQCVFYC
Q4REV4_TETNG/149-304...............GTYKFEGWRCITMDACSQ......................VHLLGDTQFVI.....HEGECMLEC
INSR_XENLA/189-350...............GSYQFQGWRCIDFNTCQELNSR...............CQNSRDNSCPPYVI.....HKGECMPDC
MIPR_LYMST/206-359...............GTYKFLNRRCLTDKECLAL....................TNDPDGNTPKLLDGEKGEPSLCLYTC
Q86MD7_ECHMU/215-366HHVNPTTSRQELNPDFKYEL.HDICV..RQCP.............................EPLLK.....MDTVCVIEC
P79754_TAKRU/177-329LIYNKQTFQMETNPNAKYQY.GSICV..SQCP............................THFVV......DGSSCVSVC
Q8UW84_PAROL/181-335...............GTYKFESWRCITMDLCSQ......................VHLPGDPQFVI.....HGGECMHDC
Q5EBY4_DANRE/181-338TIYDPITFQSKPNKDKKFSF.GATCV..KQCP............................HNYLAM.....EV.ACTMVC
LET23_CAEEL/214-369KIFNHKTGRLVFNPDGRYQN.GNHCV..KECP.............................PELLI.....ENDVCVRHC
Q153D8_XENLA/183-342STYNPETYESVHNEGGRYTF.GASCV..TSCP............................YNYLAT.....EVGSCTLFC
A6P6W2_COTJA/175-333...............NTYKFEGWRCVTKEFCSKVP...................ATETSDYERFVI.....HNDECMAEC
HTK7_HYDVU/189-344...............KQYLVDKFLCQ..ESCPYW.....................SINSTEYHHYL.....WQGECVTKC
Q17D67_AEDAE/155-304QRYNPTNYLWEPNPEGKYAY.GATCV..RNCP.............................EHLLK.....DNGACVRTC
Q7Q0F6_ANOGA/194-348...............HMFLFSESRCLTEEECYKIYKPLQ...........RIADITD...NYPYVP.....AQGECRLDC
Q4RXV8_TETNG/185-366LIYNKYTFRLEPNPNAKFQF.GSICV..AQCPRQYPPRLLRLKSASSFVFIPALLCFLYSANFLV......DGTSCVRSC
INSR_DROME/509-648...............GYYQF.DSRCVTANECITLT...................KFETNSVYSGIP.....YNGQCITHC

PF15913

H9GP38_ANOCA/86-194---------------GFHL----------------------------------------------------HKGRCY.NC
RSPO4_HUMAN/35-140---------------QFYL----------------------------------------------------YKGKCLPTC
G5AJQ8_HETGA/35-140---------------RFFL----------------------------------------------------HKGKCLPTC
H9GGW4_ANOCA/2-111---------------QFYL----------------------------------------------------HKGKCLSTC
G1K3B0_XENTR/36-142---------------GFYS----------------------------------------------------HKGQCFEEC
H3ABT8_LATCH/20-126---------------GFYL----------------------------------------------------FKGKCLISC
F8W4P8_DANRE/38-142---------------GFLL----------------------------------------------------FKGKCFKSC
H2SL31_TAKRU/42-148---------------GFYL----------------------------------------------------HKGRCFDRC
F6USY9_ORNAN/37-145---------------GYYI----------------------------------------------------HMGKCLDSC
H0YTH5_TAEGU/40-149---------------GLYL----------------------------------------------------HKGRCYVTC
H2S9X8_TAKRU/44-150---------------GFYL----------------------------------------------------HLGKCQETC
RSPO1_DANRE/41-147---------------GLYS----------------------------------------------------HRGRCFSSC
H2MI93_ORYLA/41-153---------------GLYS----------------------------------------------------HSGRCYVSC
E1BVQ0_CHICK/35-141---------------KFYL----------------------------------------------------HKGQCFRQC
F6T8G8_XENTR/42-147---------------GFYK----------------------------------------------------HNGKCLDTC
F7EGR5_XENTR/41-147---------------GFYS----------------------------------------------------HKGSCYSSC

PF14843

F2U6Q9_SALR5/180-312NAM----------------C..DGCF-GP-SNAD----CA
A8WPC3_CAEBR/574-697HAT----------------CYENGCT-GP-SSNL----GP
E3NFJ5_CAERE/507-626YEN----------------G....LH-TR-SSDA----LH
Q23821_CAERE/560-683HPT----------------CYENGCT-GS-DSNL----GH
Q4RG29_TETNG/491-621NTN----------------C.TLSCT-VK-DERG----CP
Q923V5_RAT/34-167PIN----------------C.THSCV-DL-DERG----CP
Q153D8_XENLA/509-641PVN----------------C.SHLCN-QM-DERG----CP
F1QYI3_DANRE/475-607HPN----------------C.TQGSV-AC-NRFR----CR
F1M7X4_RAT/475-607HPN----------------C.TQGCN-GP-TSHD----CI
Q153D9_XENLA/519-651HPN----------------C.TDGCR-GP-RLKD----CI
ERBB3_RAT/499-630HEN----------------C.TQGCN-GP-ELQD----CL
Q2HZD7_CHICK/500-631HEN----------------C.TRGCT-GP-LLQD----CL
E9QC99_DANRE/495-628HFN----------------C.TRGCT-GP-ALRD----CV
P79754_TAKRU/494-627HQN----------------C.TQGCS-GP-GLND----CL
Q9YH40_XIPXI/501-633HQN----------------C.TQGCS-GP-GLSG----CR
Q6VQA3_DANRE/503-635HEN----------------C.TQGCT-GP-DLKD----CK
Q4RWY4_TETNG/474-606HRN----------------C.TQGCT-GP-GLAG----CQ
Q153D7_XENLA/91-223HPE----------------C.KLGCA-GH-GIDG----CP
E7CXR8_RAT/505-637HAN----------------C.TYGCA-GP-GLKG----CQ
A5A753_PIG/500-632HPN----------------C.TYGCV-GP-GLEG----CA
D0RB24_NOTVI/501-633HVN----------------C.TEGCF-GP-DLEG----CP
E1C0S3_CHICK/515-650HPN----------------C.TRGCK-GP-GLEG----CP
Q9BIH9_ANOGA/471-584HKT----------------C..VGCR-GP-RDTI----AP
X1XZ97_ANODA/494-602HKT----------------C..VGMS-WS-A...----..
Q6SAX4_DROME/471-583HAT----------------C..DGCT-GP-KDTI----GI
B4LLF8_DROVI/581-693HET----------------C..EGCT-GP-NNTI----GH
B3MC66_DROAN/584-696HAT----------------C..EGCT-GP-KDTI----GL
E0W212_PEDHC/466-580HPN----------------C.VNGCT-GP-ENTI----GP
E2CA29_HARSA/483-596HQN----------------C.VGGCE-GP-ENNI----GA

PF00757

INSR_HUMAN/179-340PSGYTMN.......SSNLLC--TPCL.GP.CPKV----CH
Q1LVG4_DANRE/171-332PSGYTTVN......STSLTC--MPCT.GR.CPKV----CT
INSR_AEDAE/196-357PLDHELITE....LNKTRWC--RKCS.GT.CPKR----CE
Q4RG29_TETNG/162-318PKPNPKDVVPQPCGNDTQKC--EKCE.GD.CPKV----CY
Q2HZD7_CHICK/183-335PSNKMEVE.....KNGLKMC--EPCA.GL.CPKA----CE
Q6SAA1_DROME/154-303PQDKM.........DKGGEC--VPCN.GP.CPKT----CP
Q9W6F6_CHICK/31-183PSSKMEVE.....ENGIKMC--KPCT.DI.CPKA----CD
O93457_PSEMX/181-336PSGYTRTT......PDSMTC--TACD.GL.CDKV----CE
Q6QMR8_DANRE/182-336SPGTYEVD.....EGGVRKC--KRCE.GL.CPKG----TT
ILPR_BRALA/178-321PSGYTTDI......NNPRLC--TECE.GQ.CPKS----CK
IGF1R_XENLA/172-329PSGYMLNK......SQSMTC--SPCE.GP.CPKI----CE
Q4S8B8_TETNG/198-353PSGYTRST......TDNMSC--TACD.GL.CDKV----CE
Q4RUB0_TETNG/145-331PSGYTTIN......TTTLTC--SPCA.GL.CPKL----CL
Q2EJ72_CHICK/180-332PQNSQEVT.....VNNVQKC--EKCS.KP.CPEV----CY
A2IRM8_CYNPY/177-334PSGFTRNG......SQSMFC--SPCE.GP.CPKI----CE
Q4RWY4_TETNG/154-308SGNTYEIE.....EGGIRKC--AKCD.GL.CPKV----CN
Q9YH40_XIPXI/187-340SAGMLEVD.....ENGKRSC--KPCD.GV.CPKV----CD
INSRR_HUMAN/173-329PSGFTRN.......SSSIFC--HKCE.GL.CPKE----CK
Q1LWJ4_DANRE/181-336PPGFTRNE......TQSMFC--SACD.GL.CDKV----CE
Q6PA47_XENLA/176-333PPGYTR........NDSILC--HKCV.GL.CPKT----CK
ERBB2_CANFA/189-343PLNNQEVTA....EDGTQRC--EKCS.KP.CARV----CY
Q8MIL8_PIG/184-338SSDSYEVE.....EDGVRKC--KKCD.GP.CGKV----CN
Q4H3N3_CIOIN/233-394PEGTFD........YNSNIC--EPCENGK.CEHV----CY
Q8UW85_PAROL/178-344PSGYTTVN......SSSLNC--MPCA.GL.CPKV----CM
Q9NJV5_BIOGL/183-333PQNYTIREL...KEKNYNEC--VKCT.GF.CHKE----CS
Q4REV4_TETNG/149-304PSGFKRNE......TNQMFC--SACN.GP.CDKS----CR
INSR_XENLA/189-350PSGYIAN.......STTRTC--TPCA.GP.CPKV----CT
MIPR_LYMST/206-359PQNYSVGDSK..DNKNLSQC--VKCR.QL.CPKE----CH
Q86MD7_ECHMU/215-366DFKTTI........PVNGSC--VPCA.KTPCANH----CE
P79754_TAKRU/177-329PPDKMEVE.....RGSQRQC--ELCS.GL.CPKV----CE
Q8UW84_PAROL/181-335PSGFTRNE......TNRMFC--SACN.GL.CDKV----CT
Q5EBY4_DANRE/181-338PKANKEVISVEPDGQETQKC--EKCE.GE.CPKV----CY
LET23_CAEEL/214-369SDGHHYDA.....TKDVREC--EKCR.SSSCPKI----CT
Q153D8_XENLA/183-342PKDNKEVI.....VGNMQKC--EKCD.KQ.CSKV----CY
A6P6W2_COTJA/175-333PSGFIRNG......SQSMFC--SPCE.GP.CPKI----CE
HTK7_HYDVU/189-344PVNYISN.......NQTKKC--EKCKSGMKCNTV----CK
Q17D67_AEDAE/155-304PSNKM.........AQNGEC--VPCN.GA.CPKT----CQ
Q7Q0F6_ANOGA/194-348PLGYTLTRA...TGSQRLAC--VPCK.GP.CRSE----CK
Q4RXV8_TETNG/185-366PADKMEVE.....KNGVKRC--EPCG.GL.CPKA----CH
INSR_DROME/509-648PTGYQKS.......ENKRMC--EPCPGGK.CDKE----CS

PF15913

H9GP38_ANOCA/86-194TKDFSAA-------NSTVEC--N...----SPAQ....CE
RSPO4_HUMAN/35-140PPGTLAH-------QNTREC--Q..G----...E....CE
G5AJQ8_HETGA/35-140PPGTLTH-------QSTREC--Q..E----...E....CK
H9GGW4_ANOCA/2-111PLDTIAQ-------PSTQEC--LSKP----..EK....CE
G1K3B0_XENTR/36-142PEGFAPL-------DDTMVC--V..D----...G....CE
H3ABT8_LATCH/20-126PEGTAPD-------QQQREC--F..E----...E....WG
F8W4P8_DANRE/38-142PEGTFAQ-------.ST.DC--V..E----...G....CV
H2SL31_TAKRU/42-148PEGFAPL-------DETMEC--G..E----...G....CE
F6USY9_ORNAN/37-145PEGLETN-------NHTMEC--T.SV----..VH....CE
H0YTH5_TAEGU/40-149PEGYAAA-------NGTMEC--SSPA----...Q....CE
H2S9X8_TAKRU/44-150PEGLVRN-------EAQREC--A.PM----...H....CE
RSPO1_DANRE/41-147PEGFTV.-------NGTMEC--V..V----...Q....CD
H2MI93_ORYLA/41-153PPGQRTA-------NETMEC--V..G----...QHALKCE
E1BVQ0_CHICK/35-141PPSTAAQ-------PGTREC--Q..E----...T....CE
F6T8G8_XENTR/42-147PEGFEN.-------NHNMEC--T..S----V.VH....C.
F7EGR5_XENTR/41-147PEGFSAV-------NGTAEC--S..S----..VQ....CE

This alignment is coloured according to the ClustalX colouring scheme:

 
Glycine (G)
 
Proline (P)
 
Small or hydrophobic (C,A,V,L,I,M,F,W)
 
Hydroxyl or amine amino acids (S,T,N,Q)
 
Charged amino-acids (D,E,R,K)
 
Histidine or tyrosine (H,Y)

For UniProt-based alignments, we also add some additional mark-up to the alignments where appropriate. Active site information is shown as follows:

 
Active site (residue annotated in SwissProt as an active site)
 
Predicted active site (residue aligns in a Pfam alignment with a SwissProt active site)
 
Predicted active site (residue annotated in SwissProt as a potential active site)

Some UniProt sequences can be mapped to protein structures, in which case we also show the secondary structure definition. These lines are shown below the sequence to which they apply and are marked (SS). The meaning of each of the symbols is as follows:

C
Random coil
H
Alpha-helix
G
3(10) helix
I
Pi-helix
E
Hydrogen bonded beta-strand (extended strand)
B
Residue in isolated beta-bridge
T
H-bonded turn (3-turn, 4-turn, or 5-turn)
S
Bend (five-residue bend centered at residue i)
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