Please note: this site relies heavily on the use of javascript. Without a javascript-enabled browser, this site will not function correctly. Please enable javascript and reload the page, or switch to a different browser.
0  structures 3953  species 0  interactions 10451  sequences 55  architectures

Clan: NicO_HupE_DsbD (CL0549)


NicO/HupE/DsdD superfamily Add an annotation

This clan contains the nickel transpot family NicO [1-2] and the HupE/UreJ proteins, which may be involved in nickel binding. NicO and HupE contain a conserved GxxHxxxDH motif, which may bind to nickel.

This clan contains 6 families and the total number of domains in the clan is 10451. The clan was built by R Eberhardt.

Literature references

  1. Fu C, Javedan S, Moshiri F, Maier RJ; , Proc Natl Acad Sci U S A 1994;91:5099-5103.: Bacterial genes involved in incorporation of nickel into a hydrogenase enzyme. PUBMED:8197192 EPMC:8197192
  2. Mobley HL, Garner RM, Bauerfeind P; , Mol Microbiol 1995;16:97-109.: Helicobacter pylori nickel-transport gene nixA: synthesis of catalytically active urease in Escherichia coli independent of growth conditions. PUBMED:7651142 EPMC:7651142


This clan contains the following 6 member families:

DsbD DsbD_2 DUF2910 HupE_UreJ HupE_UreJ_2 NicO

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DsbD (PF02683) 5377 (51.4%) View
NicO (PF03824) 2471 (23.6%) View
DsbD_2 (PF13386) 1138 (10.9%) View
DUF2910 (PF11139) 566 (5.4%) View
HupE_UreJ (PF04955) 494 (4.7%) View
HupE_UreJ_2 (PF13795) 405 (3.9%) View
Total: 6 Total: 10451 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...