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22  structures 791  species 2  interactions 3673  sequences 111  architectures

Clan: LisH (CL0561)

Summary

LisH-like Add an annotation

Members of this clan include the LisH dimerisation/tetramerisation domains and the FOP N terminal dimerisation domain.

This clan contains 3 families and the total number of domains in the clan is 3673. The clan was built by R Eberhardt.

Literature references

  1. Mikolajka A, Yan X, Popowicz GM, Smialowski P, Nigg EA, Holak TA; , J Mol Biol. 2006;359:863-875.: Structure of the N-terminal domain of the FOP (FGFR1OP) protein and implications for its dimerization and centrosomal localization. PUBMED:16690081 EPMC:16690081
  2. Oberoi J, Fairall L, Watson PJ, Yang JC, Czimmerer Z, Kampmann T, Goult BT, Greenwood JA, Gooch JT, Kallenberger BC, Nagy L, Neuhaus D, Schwabe JW;, Nat Struct Mol Biol. 2011;18:177-184.: Structural basis for the assembly of the SMRT/NCoR core transcriptional repression machinery. PUBMED:21240272 EPMC:21240272

Members

This clan contains the following 3 member families:

FOP_dimer LisH LisH_2

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
LisH (PF08513) 3063 (83.4%) View
FOP_dimer (PF09398) 330 (9.0%) View
LisH_2 (PF16045) 280 (7.6%) View
Total: 3 Total: 3673 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
FOP_dimer FOP_dimer
LisH LisH

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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