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4  structures 1886  species 1  interaction 3469  sequences 72  architectures

Clan: GHKL (CL0565)


ATPase domain of HSP90, DNA topoisomerase II and histidine kinase Add an annotation

The GHKL (gyrase, Hsp90, histidine kinase, MutL) superfamily is characterised by an eight-stranded mixed beta-sheet in two layers - alpha/beta. This is the unconventional Bergerat ATP-binding fold and is thus the most singular unifying feature of this superfamily.

This clan contains 1 families and the total number of domains in the clan is 3469. The clan was built by P Coggill.

Literature references

  1. Dutta R, Inouye M;, Trends Biochem Sci. 2000;25:24-28.: GHKL, an emergent ATPase/kinase superfamily. PUBMED:10637609 EPMC:10637609


This clan contains the following 1 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
HATPase_c_4 (PF13749) 3469 (100.0%) View
Total: 1 Total: 3469 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There is 1 interaction for this clan. More...

Interacting families
AlbA_2 HATPase_c_4


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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