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48  structures 724  species 1  interaction 4422  sequences 76  architectures

Clan: KA1-like (CL0573)

Summary

Kinase associated domain 1-like Add an annotation

This superfamily is characterised by small adenylate-sensing domains at the C-terminus of molecules such as AMP-Activated Protein Kinases an SNF1-like protein kinases [1].

This clan contains 3 families and the total number of domains in the clan is 4422. The clan was built by P Coggill.

Literature references

  1. Moravcevic K, Mendrola JM, Schmitz KR, Wang YH, Slochower D, Janmey PA, Lemmon MA;, Cell. 2010;143:966-977.: Kinase associated-1 domains drive MARK/PAR1 kinases to membrane targets by binding acidic phospholipids. PUBMED:21145462 EPMC:21145462

Members

This clan contains the following 3 member families:

AdenylateSensor KA1 NAF

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
NAF (PF03822) 1895 (42.9%) View
KA1 (PF02149) 1753 (39.6%) View
AdenylateSensor (PF16579) 774 (17.5%) View
Total: 3 Total: 4422 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There is 1 interaction for this clan. More...

Interacting families
A B
EF-hand_5 NAF

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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