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11  structures 455  species 3  interactions 1103  sequences 73  architectures

Clan: KIX_like (CL0589)


Kix domain of CBP (creb binding protein) and MED13/15 Add an annotation

This superfamily is characterised by structures with three helices in a partly opened bundle bundle. There are both creb-binding proteins and activator-binding proteins on mediator subunits, such as higher eukaryotic 13 and fungal 15.

This clan contains 2 families and the total number of domains in the clan is 1103. The clan was built by P Coggill.


This clan contains the following 2 member families:


External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
KIX_2 (PF16987) 653 (59.2%) View
KIX (PF02172) 450 (40.8%) View
Total: 2 Total: 1103 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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