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181  structures 294  species 19  interactions 6271  sequences 454  architectures

Clan: Kringle (CL0602)

Summary

Kringle/FnII superfamily Add an annotation

This superfamily includes both Kringle domains and fibronectin type II domains.

This clan contains 2 families and the total number of domains in the clan is 6271. The clan was built by A Bateman.

Literature references

  1. Patthy L, Trexler M, Vali Z, Banyai L, Varadi A;, FEBS Lett. 1984;171:131-136.: Kringles: modules specialized for protein binding. Homology of the gelatin-binding region of fibronectin with the kringle structures of proteases. PUBMED:6373375 EPMC:6373375

Members

This clan contains the following 2 member families:

fn2 Kringle

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Kringle (PF00051) 4100 (65.4%) View
fn2 (PF00040) 2171 (34.6%) View
Total: 2 Total: 6271 Clan alignment
 

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 19 interactions for this clan. More...

Interacting families
A B
CIMR fn2
fn1 fn2
fn2 fn1
fn2
Hemopexin
Insulin
Peptidase_M10
PG_binding_1
Gla Kringle
Kringle Kringle
PAN_1
Trypsin
UPAR_LY6
VEK-30
PAN_1 Kringle
Peptidase_M10 fn2
PG_binding_1 fn2
Trypsin Kringle
UPAR_LY6 Kringle

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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