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572  structures 9443  species 14  interactions 49434  sequences 358  architectures

Clan: AA_dh_N (CL0603)


Aminoacid dehydrogenase-like, N-terminal domain superfamily Add an annotation

According to SCOP this superfamilies core fold has 3 layers in an alpha/beta/alpha configuration. Its central parallel beta sheet of four stands has the order 2134. In amino acid dehydrogenases this domain participates in dimerisation. This superfamily also includes domains from tetrahydrofolate dehydrogenase/cyclohydrolase, methylene-tetrahydromethanopterin dehydrogenase and shikimate dehydrogenase.

This clan contains 5 families and the total number of domains in the clan is 49434. The clan was built by A Bateman.


This clan contains the following 5 member families:

ELFV_dehydrog_N malic Mpt_N Shikimate_dh_N THF_DHG_CYH

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
malic (PF00390) 13889 (28.1%) View
ELFV_dehydrog_N (PF02812) 12323 (24.9%) View
THF_DHG_CYH (PF00763) 11518 (23.3%) View
Shikimate_dh_N (PF08501) 11370 (23.0%) View
Mpt_N (PF09176) 334 (0.7%) View
Total: 5 Total: 49434 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



There are 14 interactions for this clan. More...

Interacting families
DHquinase_I Shikimate_dh_N
ELFV_dehydrog ELFV_dehydrog_N
ELFV_dehydrog_N ELFV_dehydrog
malic malic
Malic_M malic
Mpt_N Mpt_N
Shikimate_DH Shikimate_dh_N
Shikimate_dh_N Shikimate_DH


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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