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15  structures 1958  species 5  interactions 5139  sequences 128  architectures

Clan: SPOC (CL0616)


SPOC domain-like superfamily Add an annotation

The crystal structure of the SPOC domain [3] showed it has similarity with the beta barrel domain of the Ku proteins. These domains share a 7 stranded beta barrel. In the Ku proteins this domain interacts DNA, whereas the SPOC domain mediates protein binding.

This clan contains 3 families and the total number of domains in the clan is 5139. The clan was built by A Bateman.

Literature references

  1. Sanchez-Pulido L, Rojas AM, van Wely KH, Martinez-A C, Valencia A;, BMC Bioinformatics. 2004;5:91.: SPOC: a widely distributed domain associated with cancer, apoptosis and transcription. PUBMED:15239844 EPMC:15239844
  2. Mikami S, Kanaba T, Ito Y, Mishima M;, Biomol NMR Assign. 2013;7:267-270.: NMR assignments of SPOC domain of the human transcriptional corepressor SHARP in complex with a C-terminal SMRT peptide. PUBMED:22987228 EPMC:22987228
  3. Ariyoshi M, Schwabe JW; , Genes Dev 2003;17:1909-1920.: A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling. PUBMED:12897056 EPMC:12897056


This clan contains the following 3 member families:

Ku Med25 SPOC

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Ku (PF02735) 3147 (61.2%) View
SPOC (PF07744) 1732 (33.7%) View
Med25 (PF11232) 260 (5.1%) View
Total: 3 Total: 5139 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 5 interactions for this clan. More...

Interacting families
Ku Ku
Ku_C Ku
Ku_N Ku


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...