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9  structures 130  species 7  interactions 508  sequences 7  architectures

Clan: Colipase (CL0621)


Colipase-like superfamily Add an annotation

This superfamily includes the two subdomains of colipase along with the black mamba Intestinal toxin 1 [1]. This superfamily has a knottin fold.

This clan contains 3 families and the total number of domains in the clan is 508. The clan was built by A Bateman.

Literature references

  1. Boisbouvier J, Albrand JP, Blackledge M, Jaquinod M, Schweitz H, Lazdunski M, Marion D;, J Mol Biol. 1998;283:205-219.: A structural homologue of colipase in black mamba venom revealed by NMR floating disulphide bridge analysis. PUBMED:9761684 EPMC:9761684


This clan contains the following 3 member families:

Colipase Colipase_C Prokineticin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Prokineticin (PF06607) 314 (61.8%) View
Colipase_C (PF02740) 103 (20.3%) View
Colipase (PF01114) 91 (17.9%) View
Total: 3 Total: 508 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 7 interactions for this clan. More...

Interacting families
Colipase Colipase_C
Colipase_C PLAT
Lipase Colipase
PLAT Colipase


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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