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119  structures 3884  species 5  interactions 7869  sequences 36  architectures

Clan: CcdB_PemK (CL0624)


Cell growth inhibitor/plasmid maintenance toxic component superfamily Add an annotation

This superfamily includes cell growth inhibitors and toxin components. These proteins share an SH3-like barrel structure.

This clan contains 3 families and the total number of domains in the clan is 7869. The clan was built by A Bateman.


This clan contains the following 3 member families:

CcdB DUF1918 PemK_toxin

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PemK_toxin (PF02452) 6607 (84.0%) View
DUF1918 (PF08940) 737 (9.4%) View
CcdB (PF01845) 525 (6.7%) View
Total: 3 Total: 7869 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 5 interactions for this clan. More...

Interacting families
CcdB CcdA
DNA_topoisoIV CcdB
PemK_toxin MazE_antitoxin


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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