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146  structures 946  species 4  interactions 8413  sequences 303  architectures

Clan: Fz (CL0644)


Frizzled cysteine-rich domain-related superfamily Add an annotation

This superfamily includes diverse cysteine rich domains identified as being homologous [1].

This clan contains 4 families and the total number of domains in the clan is 8413. The clan was built by A Bateman.

Literature references

  1. Cheng H, Schaeffer RD, Liao Y, Kinch LN, Pei J, Shi S, Kim BH, Grishin NV;, PLoS Comput Biol. 2014;10:e1003926.: ECOD: an evolutionary classification of protein domains. PUBMED:25474468 EPMC:25474468


This clan contains the following 4 member families:

Folate_rec Fz Glypican NPC1_N

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Fz (PF01392) 4329 (51.5%) View
Glypican (PF01153) 1519 (18.1%) View
NPC1_N (PF16414) 1494 (17.8%) View
Folate_rec (PF03024) 1071 (12.7%) View
Total: 4 Total: 8413 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 4 interactions for this clan. More...

Interacting families
Folate_rec Folate_rec
Fz Fz
Glypican Glypican


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...