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22  structures 3879  species 10  interactions 8786  sequences 110  architectures

Clan: Anti-sigma_N (CL0645)


N-terminal, cytoplasmic domain of anti-sigma factor superfamily Add an annotation

This clan contains 2 families and the total number of domains in the clan is 8786. The clan was built by A Bateman.


This clan contains the following 2 member families:

RseA_N zf-HC2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
zf-HC2 (PF13490) 7579 (86.3%) View
RseA_N (PF03872) 1207 (13.7%) View
Total: 2 Total: 8786 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 10 interactions for this clan. More...

Interacting families
RseA_N RseA_N
Sigma70_r2 RseA_N
Sigma70_r4 zf-HC2
Sigma70_r4_2 RseA_N
SspB RseA_N
zf-HC2 Cupin_7


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...