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0  structures 15  species 0  interactions 1878  sequences 38  architectures

Clan: VSA (CL0656)

Summary

Variant surface antigens Add an annotation

Members of this clan belong to variant surfance antigens (VSA). They are gene products encoded by multi-copy gene families. Four of the largest multi-copy gene families found in the genome of P. falciparum are designated as var, rif (repetitive interspersed family), stevor (subtelomeric variable open reading frame) and pfmc-2tm (P. falciparum Maurer’s clefts 2 transmembrane). They code for variable proteins termed PfEMP1 (P. falciparum erythrocyte membrane protein 1), RIFIN, STEVOR and PfMC-2TM, respectively. All small VSA proteins contain a signal peptide and a PEXEL/HT motif. This characteristic as well as their large number and hypervariability support their suggested role in antigenic variation. Antigenic variation and sequestration are strategies used by the malaria parasite P. falciparum to evade antibody mediated immune recognition and splenic clearance [1].

This clan contains 2 families and the total number of domains in the clan is 1878. The clan was built by S El-Gebali.

Literature references

  1. Bachmann A, Scholz JA, Janssen M, Klinkert MQ, Tannich E, Bruchhaus I, Petter M;, Malar J. 2015;14:274.: A comparative study of the localization and membrane topology of members of the RIFIN, STEVOR and PfMC-2TM protein families in Plasmodium falciparum-infected erythrocytes. PUBMED:26173856 EPMC:26173856

Members

This clan contains the following 2 member families:

RIFIN Stevor

Domain organisation

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
RIFIN (PF02009) 1511 (80.5%) View
Stevor (PF17410) 367 (19.5%) View
Total: 2 Total: 1878 Clan alignment
 

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Family relationships

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Species distribution

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