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51  structures 1124  species 5  interactions 15328  sequences 1763  architectures

Clan: Gain (CL0661)

Summary

GPCR autoproteolysis inducing Add an annotation

Members of this clan belong to GAIN domain with an autoproteolytic motif. The G-protein-coupled receptor (GPCR) autoproteolysis-inducing (GAIN) domain, includes GPCRs involved in adhesion with a characteristic autoproteolysis motif of HLT/S known as the GPCR proteolysis site (GPS). GPS is also shared by polycystic kidney disease (PKD) proteins. GAIN has been shown to be both necessary and sufficient for autoproteolysis [1].

This clan contains 6 families and the total number of domains in the clan is 15328. The clan was built by S El-Gebali.

Literature references

  1. Liao Y, Pei J, Cheng H, Grishin NV;, J Mol Biol. 2014;426:3935-3945.: An ancient autoproteolytic domain found in GAIN, ZU5 and Nucleoporin98. PUBMED:25451782 EPMC:25451782

Members

This clan contains the following 6 member families:

DUF1191 GAIN GPS Nucleoporin2 UPF0560 ZU5

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GPS (PF01825) 5641 (36.8%) View
ZU5 (PF00791) 4532 (29.6%) View
GAIN (PF16489) 2456 (16.0%) View
Nucleoporin2 (PF04096) 1615 (10.5%) View
UPF0560 (PF10577) 611 (4.0%) View
DUF1191 (PF06697) 473 (3.1%) View
Total: 6 Total: 15328 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 5 interactions for this clan. More...

Interacting families
A B
GPS GPS
Nucleoporin2 Nucleoporin2
Spectrin ZU5
ZU5 Death
ZU5

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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