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12  structures 987  species 0  interactions 3693  sequences 68  architectures

Clan: BET (CL0665)

Summary

BET superfamily Add an annotation

The BET (bromodomain extra-terminal) superfamily includes the BET domain as well as the AHD domain from AF-9.

This clan contains 2 families and the total number of domains in the clan is 3693. The clan was built by A Bateman.

Literature references

  1. Rahman S, Sowa ME, Ottinger M, Smith JA, Shi Y, Harper JW, Howley PM;, Mol Cell Biol. 2011;31:2641-2652.: The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. PUBMED:21555454 EPMC:21555454
  2. Leach BI, Kuntimaddi A, Schmidt CR, Cierpicki T, Johnson SA, Bushweller JH;, Structure. 2013;21:176-183.: Leukemia fusion target AF9 is an intrinsically disordered transcriptional regulator that recruits multiple partners via coupled folding and binding. PUBMED:23260655 EPMC:23260655

Members

This clan contains the following 2 member families:

AHD BET

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
BET (PF17035) 3340 (90.4%) View
AHD (PF17793) 353 (9.6%) View
Total: 2 Total: 3693 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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