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36  structures 172  species 1  interaction 2085  sequences 59  architectures

Clan: Vault (CL0666)


Major Vault Protein repeat superfamily Add an annotation

This superfamily contains the Maor Vault Protein repeat domains.

This clan contains 4 families and the total number of domains in the clan is 2085. The clan was built by A Bateman.

Literature references

  1. Querol-Audi J, Casanas A, Uson I, Luque D, Caston JR, Fita I, Verdaguer N;, EMBO J. 2009;28:3450-3457.: The mechanism of vault opening from the high resolution structure of the N-terminal repeats of MVP. PUBMED:19779459 EPMC:19779459


This clan contains the following 4 member families:

Vault Vault_2 Vault_3 Vault_4

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Vault (PF01505) 1063 (51.0%) View
Vault_2 (PF17794) 478 (22.9%) View
Vault_4 (PF17796) 273 (13.1%) View
Vault_3 (PF17795) 271 (13.0%) View
Total: 4 Total: 2085 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There is 1 interaction for this clan. More...

Interacting families
Vault Vault


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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