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12  structures 5421  species 2  interactions 14609  sequences 157  architectures

Clan: Fer2_BFD (CL0667)


Bacterioferritin-associated ferredoxin superfamily Add an annotation

This clan includes the Bacterioferritin-associated ferredoxin which is a 2Fe-2S domain. The clan also includes the related Bacterioferritin-associated ferredoxin which lacks the iron sulfur cluster.

This clan contains 2 families and the total number of domains in the clan is 14609. The clan was built by A Bateman.

Literature references

  1. Yao H, Wang Y, Lovell S, Kumar R, Ruvinsky AM, Battaile KP, Vakser IA, Rivera M;, J Am Chem Soc. 2012;134:13470-13481.: The structure of the BfrB-Bfd complex reveals protein-protein interactions enabling iron release from bacterioferritin. PUBMED:22812654 EPMC:22812654
  2. Chen ZW, Hassan-Abdulah A, Zhao G, Jorns MS, Mathews FS;, J Mol Biol. 2006;360:1000-1018.: Heterotetrameric sarcosine oxidase: structure of a diflavin metalloenzyme at 1.85 A resolution. PUBMED:16820168 EPMC:16820168


This clan contains the following 2 member families:

Fer2_BFD SO_alpha_A3

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Fer2_BFD (PF04324) 12534 (85.8%) View
SO_alpha_A3 (PF17806) 2075 (14.2%) View
Total: 2 Total: 14609 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 2 interactions for this clan. More...

Interacting families
Fer2_BFD Fer2_BFD
Ferritin Fer2_BFD


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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