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1140  structures 9824  species 14  interactions 190461  sequences 2505  architectures

Clan: AAA_lid (CL0671)


AAA+ ATPase lid domain superfamily Add an annotation

Many AAA+ proteins have a C-terminal alpha-helical bundle in addition to the AAA core [1]. The functional roles of the helical bundle are varied and include the formation of a lid over the nucleotide binding site and mediation of subunit interactions in oligomeric protein complexes [1].

This clan contains 22 families and the total number of domains in the clan is 190461. The clan was built by A Bateman.

Literature references

  1. Miller JM, Enemark EJ;, Archaea. 2016;2016:9294307.: Fundamental Characteristics of AAA+ Protein Family Structure and Function. PUBMED:27703410 EPMC:27703410


This clan contains the following 22 member families:

AAA_assoc_2 AAA_lid_1 AAA_lid_10 AAA_lid_11 AAA_lid_2 AAA_lid_3 AAA_lid_4 AAA_lid_5 AAA_lid_6 AAA_lid_7 AAA_lid_8 AAA_lid_9 CbbQ_C ClpB_D2-small Dpoe2NT MCM_lid Mg_chelatase_C ORC4_C PCP_red TIP49_C UVR Vps4_C

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

Loading domain graphics...


The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
AAA_lid_3 (PF17862) 43200 (22.7%) View
ClpB_D2-small (PF10431) 32707 (17.2%) View
AAA_lid_9 (PF17871) 20380 (10.7%) View
UVR (PF02151) 17098 (9.0%) View
AAA_lid_2 (PF17863) 14861 (7.8%) View
MCM_lid (PF17855) 8646 (4.5%) View
AAA_assoc_2 (PF16193) 8258 (4.3%) View
AAA_lid_4 (PF17864) 7662 (4.0%) View
Mg_chelatase_C (PF13335) 6634 (3.5%) View
AAA_lid_11 (PF18198) 5668 (3.0%) View
Vps4_C (PF09336) 4424 (2.3%) View
AAA_lid_1 (PF17857) 4094 (2.1%) View
Pfam family Num. domains Alignment
AAA_lid_6 (PF17866) 3824 (2.0%) View
AAA_lid_7 (PF17867) 3048 (1.6%) View
TIP49_C (PF17856) 2434 (1.3%) View
CbbQ_C (PF08406) 1888 (1.0%) View
AAA_lid_10 (PF17872) 1445 (0.8%) View
AAA_lid_5 (PF17865) 1123 (0.6%) View
PCP_red (PF08369) 985 (0.5%) View
ORC4_C (PF14629) 977 (0.5%) View
AAA_lid_8 (PF17868) 734 (0.4%) View
Dpoe2NT (PF12213) 371 (0.2%) View
Total: 22 Total: 190461 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...



There are 14 interactions for this clan. More...

Interacting families
AAA ClpB_D2-small
AAA_2 ClpB_D2-small
ClpB_D2-small AAA_2
Helicase_C UVR
Proteasome ClpB_D2-small
Vps4_C Vps4_C


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...