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1140  structures 9824  species 14  interactions 190461  sequences 2505  architectures

Clan: AAA_lid (CL0671)

Summary

AAA+ ATPase lid domain superfamily Add an annotation

Many AAA+ proteins have a C-terminal alpha-helical bundle in addition to the AAA core [1]. The functional roles of the helical bundle are varied and include the formation of a lid over the nucleotide binding site and mediation of subunit interactions in oligomeric protein complexes [1].

This clan contains 22 families and the total number of domains in the clan is 190461. The clan was built by A Bateman.

Literature references

  1. Miller JM, Enemark EJ;, Archaea. 2016;2016:9294307.: Fundamental Characteristics of AAA+ Protein Family Structure and Function. PUBMED:27703410 EPMC:27703410

Members

This clan contains the following 22 member families:

AAA_assoc_2 AAA_lid_1 AAA_lid_10 AAA_lid_11 AAA_lid_2 AAA_lid_3 AAA_lid_4 AAA_lid_5 AAA_lid_6 AAA_lid_7 AAA_lid_8 AAA_lid_9 CbbQ_C ClpB_D2-small Dpoe2NT MCM_lid Mg_chelatase_C ORC4_C PCP_red TIP49_C UVR Vps4_C

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
AAA_lid_3 (PF17862) 43200 (22.7%) View
ClpB_D2-small (PF10431) 32707 (17.2%) View
AAA_lid_9 (PF17871) 20380 (10.7%) View
UVR (PF02151) 17098 (9.0%) View
AAA_lid_2 (PF17863) 14861 (7.8%) View
MCM_lid (PF17855) 8646 (4.5%) View
AAA_assoc_2 (PF16193) 8258 (4.3%) View
AAA_lid_4 (PF17864) 7662 (4.0%) View
Mg_chelatase_C (PF13335) 6634 (3.5%) View
AAA_lid_11 (PF18198) 5668 (3.0%) View
Vps4_C (PF09336) 4424 (2.3%) View
AAA_lid_1 (PF17857) 4094 (2.1%) View
continued
Pfam family Num. domains Alignment
AAA_lid_6 (PF17866) 3824 (2.0%) View
AAA_lid_7 (PF17867) 3048 (1.6%) View
TIP49_C (PF17856) 2434 (1.3%) View
CbbQ_C (PF08406) 1888 (1.0%) View
AAA_lid_10 (PF17872) 1445 (0.8%) View
AAA_lid_5 (PF17865) 1123 (0.6%) View
PCP_red (PF08369) 985 (0.5%) View
ORC4_C (PF14629) 977 (0.5%) View
AAA_lid_8 (PF17868) 734 (0.4%) View
Dpoe2NT (PF12213) 371 (0.2%) View
Total: 22 Total: 190461 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 14 interactions for this clan. More...

Interacting families
A B
AAA ClpB_D2-small
UVR
Vps4_C
AAA_2 ClpB_D2-small
Clp_N UVR
ClpB_D2-small AAA_2
Proteasome
Helicase_C UVR
MecA UVR
Proteasome ClpB_D2-small
ResIII UVR
UVR UVR
Vps4_C Vps4_C
Vta1

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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