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14  structures 2266  species 2  interactions 5674  sequences 154  architectures

Clan: GYF (CL0673)

Summary

GYF domain Add an annotation

GYF domains are small, versatile adaptor domains that recognize proline-rich sequences (PRS). Mutational and structural analysis has shown the conserved signature W-X-Y-X6-11-GPF-X4-M-X2-W-X3-GYF to be the site of interaction with proline-rich peptides. In contrast, composition and length of the C-terminal half of GYF domains are not conserved. GYF domains bind to many different PRS that converge on a minimal consensus sequence [1].

This clan contains 2 families and the total number of domains in the clan is 5674. The clan was built by S El-Gebali.

Literature references

  1. Kofler MM, Freund C;, FEBS J. 2006;273:245-256.: The GYF domain. PUBMED:16403013 EPMC:16403013

Members

This clan contains the following 2 member families:

GYF GYF_2

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
GYF (PF02213) 3085 (54.4%) View
GYF_2 (PF14237) 2589 (45.6%) View
Total: 2 Total: 5674 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
DIM1 GYF
GYF GYF

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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