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0  structures 4068  species 0  interactions 4752  sequences 8  architectures

Clan: AmpE_CobD-like (CL0685)

Summary

AmpE/CobD like Add an annotation

This clan contains the AmpE bacterial family of signalling proteins. These proteins help to regulate beta-lactamase. It also contains the CobD/Cbib family of proteins which are involved in cobalamin biosynthesis. According to TCDB, members have 5 or 6 putative transmembrane regions.

This clan contains 2 families and the total number of domains in the clan is 4752. The clan was built by J Mistry.

Literature references

  1. Brushaber KR, O'Toole GA, Escalante-Semerena JC; , J Biol Chem 1998;273:2684-2691.: CobD, a novel enzyme with L-threonine-O-3-phosphate decarboxylase activity, is responsible for the synthesis of (R)-1-amino-2-propanol O-2-phosphate, a proposed new intermediate in cobalamin biosynthesis in Salmonella typhimurium LT2. PUBMED:9446573 EPMC:9446573
  2. Lindquist S, Galleni M, Lindberg F, Normark S;, Mol Microbiol. 1989;3:1091-1102.: Signalling proteins in enterobacterial AmpC beta-lactamase regulation. PUBMED:2691840 EPMC:2691840

Members

This clan contains the following 2 member families:

AmpE CobD_Cbib

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CobD_Cbib (PF03186) 4315 (90.8%) View
AmpE (PF17113) 437 (9.2%) View
Total: 2 Total: 4752 Clan alignment
 

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Family relationships

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Species distribution

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