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0  structures 228  species 0  interactions 3398  sequences 37  architectures

Clan: Zn_chelatase (CL0687)

Summary

Zinc chelating superfamily Add an annotation

This clan includes Zn-chelating domains with four conserved cysteine/histidine residues N-terminal to the catalytic domain found in most of the KDZ (Kyakuja, Dileera, and Zisupton) transposases. A subset of these elements contains further N- or C-terminal Zn-chelating domains, such as the TRMT1N-like domain, SWIM, C2H2 fingers, and CXC7 in Zisuptons and the ZZ finger in Kyakujas.hese domains could help recognize specific DNA sequences or chromatin proteins during integration [1].

This clan contains 6 families and the total number of domains in the clan is 3398. The clan was built by S El-Gebali.

Literature references

  1. Iyer LM, Zhang D, de Souza RF, Pukkila PJ, Rao A, Aravind L;, Proc Natl Acad Sci U S A. 2014;111:1676-1683.: Lineage-specific expansions of TET/JBP genes and a new class of DNA transposons shape fungal genomic and epigenetic landscapes. PUBMED:24398522 EPMC:24398522

Members

This clan contains the following 6 member families:

CxC1 CxC2 CxC3 CxC4 CxC5 CxC6

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
CxC2 (PF18803) 1508 (44.4%) View
CxC1 (PF18802) 586 (17.2%) View
CxC5 (PF18718) 420 (12.4%) View
CxC6 (PF18721) 417 (12.3%) View
CxC4 (PF18717) 371 (10.9%) View
CxC3 (PF18804) 96 (2.8%) View
Total: 6 Total: 3398 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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