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0  structures 620  species 0  interactions 872  sequences 133  architectures

Clan: BECR (CL0688)

Summary

Barnase-EndoU-ColicinE5/D-RelE like nuclease Add an annotation

This clan includes RNase of the barnase/EndoU/colicin E5/D-RelE (BECR)-like fold. The BECR fold of metal-independent endoRNases are commonly observed and extensively diversified effectors across diverse prokaryotic conflict systems such as polymorphic toxin systems, plasmid-encoded bacteriocins, and TA systems. Although BECR fold proteins are often extensively elaborated with inserts or show structural modifications, they share a conserved core of an N-terminal helix followed by four or five strands. In addition to their presence in polyvalent proteins, solo versions of these BECR domains are also found in phages; we accordingly designate this clade the phage-BECR (PBECR) domains [1].

This clan contains 7 families and the total number of domains in the clan is 872. The clan was built by S El-Gebali.

Literature references

  1. Iyer LM, Burroughs AM, Anand S, de Souza RF, Aravind L;, J Bacteriol. 2017; [Epub ahead of print]: Polyvalent Proteins, a Pervasive Theme in the Intergenomic Biological Conflicts of Bacteriophages and Conjugative Elements. PUBMED:28559295 EPMC:28559295

Members

This clan contains the following 7 member families:

DUF3519 MuF_C PBECR1 PBECR2 PBECR3 PBECR4 PBECR5

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
PBECR2 (PF18810) 214 (24.5%) View
PBECR3 (PF18812) 204 (23.4%) View
PBECR4 (PF18813) 174 (20.0%) View
MuF_C (PF18819) 134 (15.4%) View
PBECR1 (PF18809) 114 (13.1%) View
DUF3519 (PF12033) 21 (2.4%) View
PBECR5 (PF18814) 11 (1.3%) View
Total: 7 Total: 872 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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