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98  structures 726  species 0  interactions 12590  sequences 299  architectures

Clan: Saposin_like (CL0707)

Summary

Saposin-like superfamily Add an annotation

This superfamily includes proteins with the common 3D fold from saposins, composed of five amphipathic alpha-helices.

This clan contains 3 families and the total number of domains in the clan is 12590. The clan was built by A Bateman and S Chuguransky.

Literature references

  1. Hawkins CA, de Alba E, Tjandra N;, J Mol Biol. 2005;346:1381-1392.: Solution structure of human saposin C in a detergent environment. PUBMED:15713488 EPMC:15713488
  2. Parkash V, Lindholm P, Peranen J, Kalkkinen N, Oksanen E, Saarma M, Leppanen VM, Goldman A;, Protein Eng Des Sel. 2009;22:233-241.: The structure of the conserved neurotrophic factors MANF and CDNF explains why they are bifunctional. PUBMED:19258449 EPMC:19258449

Members

This clan contains the following 3 member families:

ARMET_N SapB_1 SapB_2

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
SapB_2 (PF03489) 6454 (51.3%) View
SapB_1 (PF05184) 5405 (42.9%) View
ARMET_N (PF20145) 731 (5.8%) View
Total: 3 Total: 12590 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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