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10  structures 394  species 0  interactions 2978  sequences 39  architectures

Clan: LAMP (CL0721)

Summary

LAMP superfamily Add an annotation

This superfamily includes LAMP and LAMP-like members which are structurally similar. The luminal domain has a beta-prim structure composed of 10 beta-strands, in which beta-4-8 form a planar beta-sheet and beta-1-3, 9 and 10 assembly into a bent beta-sheet opposing the planar beta-sheet [1].

This clan contains 2 families and the total number of domains in the clan is 2978. The clan was built by S Chuguransky.

Literature references

  1. Wang L, Wu D, Robinson CV, Wu H, Fu TM;, Mol Cell. 2020;80:501-511.: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. PUBMED:33065002 EPMC:33065002

Members

This clan contains the following 2 member families:

Lamp VAS1_LD

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Lamp (PF01299) 2011 (67.5%) View
VAS1_LD (PF05827) 967 (32.5%) View
Total: 2 Total: 2978 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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