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16  structures 6126  species 2  interactions 8662  sequences 35  architectures

Clan: CNF1_YfiH (CL0663)

Summary

CNF1/YfiH-like putative cysteine hydrolases Add an annotation

Members of this clan are structurally similar. Families are a class of deamidases with a common fold consisting of three-layered alpha/beta/beta sandwich, wherein two mixed 5-stranded beta sheets are flanked by a layer of two alpha helices. In a shallow cavity at the top of the alpha/beta/beta sandwich, an invariant Cys-His pair forms a catalytic dyad that is required by the toxins for deamidation activity [1]. Deamidation is used by some bacterial virulance factors to modulate eukaryotic host cell signaling systems [2].

This clan contains 4 families and the total number of domains in the clan is 8662. The clan was built by S El-Gebali.

Literature references

  1. Chao X, Muff TJ, Park SY, Zhang S, Pollard AM, Ordal GW, Bilwes AM, Crane BR;, Cell. 2006;124:561-571.: A receptor-modifying deamidase in complex with a signaling phosphatase reveals reciprocal regulation. PUBMED:16469702 EPMC:16469702
  2. Washington EJ, Banfield MJ, Dangl JL;, Microbiol Mol Biol Rev. 2013;77:527-539.: What a difference a Dalton makes: bacterial virulence factors modulate eukaryotic host cell signaling systems via deamidation. PUBMED:24006474 EPMC:24006474

Members

This clan contains the following 4 member families:

BLF1 CheD CNF1 Cu-oxidase_4

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Cu-oxidase_4 (PF02578) 5989 (69.1%) View
CheD (PF03975) 2644 (30.5%) View
CNF1 (PF05785) 26 (0.3%) View
BLF1 (PF17752) 3 (0.0%) View
Total: 4 Total: 8662 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 2 interactions for this clan. More...

Interacting families
A B
CheC CheD
Cu-oxidase_4 Cu-oxidase_4

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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