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380  structures 20682  species 35  interactions 194274  sequences 965  architectures

Clan: Calcineurin (CL0163)

Summary

Calcineurin-like phosphoesterase superfamily Add an annotation

This clan contains the calcineurin-like phosphoesterases. This clan also includes the apparently inactive homologues from the small DNA polymerase subunits [1].

This clan contains 8 families and the total number of domains in the clan is 194274. The clan was built by A Bateman.

Literature references

  1. Aravind L, Koonin EV; , Nucleic Acids Res 1998;26:3746-3752.: Phosphoesterase domains associated with DNA polymerases of diverse origins. PUBMED:9685491 EPMC:9685491

Members

This clan contains the following 8 member families:

DNA_pol_E_B FBPase_2 Metallophos Metallophos_2 Metallophos_3 PGA_cap PhoD YmdB

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Metallophos (PF00149) 132580 (68.2%) View
Metallophos_2 (PF12850) 33764 (17.4%) View
PGA_cap (PF09587) 7664 (3.9%) View
YmdB (PF13277) 7028 (3.6%) View
FBPase_2 (PF06874) 6559 (3.4%) View
PhoD (PF09423) 4447 (2.3%) View
DNA_pol_E_B (PF04042) 2172 (1.1%) View
Metallophos_3 (PF14582) 60 (0.0%) View
Total: 8 Total: 194274 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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