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524  structures 9813  species 35  interactions 118965  sequences 1841  architectures

Clan: Calcineurin (CL0163)


Calcineurin-like phosphoesterase superfamily Add an annotation

This clan contains the calcineurin-like phosphoesterases. This clan also includes the apparently inactive homologues from the small DNA polymerase subunits [1].

This clan contains 8 families and the total number of domains in the clan is 118965. The clan was built by A Bateman.

Literature references

  1. Aravind L, Koonin EV; , Nucleic Acids Res 1998;26:3746-3752.: Phosphoesterase domains associated with DNA polymerases of diverse origins. PUBMED:9685491 EPMC:9685491


This clan contains the following 8 member families:

DNA_pol_E_B FBPase_2 Metallophos Metallophos_2 Metallophos_3 PGA_cap PhoD YmdB

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Metallophos (PF00149) 87234 (73.3%) View
Metallophos_2 (PF12850) 14182 (11.9%) View
PhoD (PF09423) 5752 (4.8%) View
PGA_cap (PF09587) 4550 (3.8%) View
DNA_pol_E_B (PF04042) 3805 (3.2%) View
YmdB (PF13277) 2470 (2.1%) View
FBPase_2 (PF06874) 925 (0.8%) View
Metallophos_3 (PF14582) 47 (0.0%) View
Total: 8 Total: 118965 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...




For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...