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861  structures 16337  species 15  interactions 45381  sequences 147  architectures

Clan: Calycin (CL0116)

Summary

Calycin superfamily Add an annotation

The calycin structural superfamily [1-3] includes the lipocalins, the fatty acid-binding proteins (FABPs).

This clan contains 20 families and the total number of domains in the clan is 45381. The clan was built by A Bateman.

Literature references

  1. Flower DR, North AC, Sansom CE; , Biochim Biophys Acta 2000;1482:9-24.: The lipocalin protein family: structural and sequence overview. PUBMED:11058743 EPMC:11058743
  2. Flower DR; , FEBS Lett 1993;333:99-102.: Structural relationship of streptavidin to the calycin protein superfamily. PUBMED:8224179 EPMC:8224179
  3. Flower DR, North AC, Attwood TK; , Protein Sci 1993;2:753-761.: Structure and sequence relationships in the lipocalins and related proteins. PUBMED:7684291 EPMC:7684291

Members

This clan contains the following 20 member families:

ApoM CrtC DUF3642 DUF4488 DUF4822 His_binding Lipocalin Lipocalin_2 Lipocalin_3 Lipocalin_4 Lipocalin_5 Lipocalin_7 Lipocalin_8 META Nitrophorin NlpE Svf1 Triabin VDE ZinT

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
META (PF03724) 9438 (20.8%) View
ZinT (PF09223) 9213 (20.3%) View
Lipocalin_2 (PF08212) 7634 (16.8%) View
NlpE (PF04170) 5256 (11.6%) View
Lipocalin (PF00061) 3152 (6.9%) View
CrtC (PF07143) 2962 (6.5%) View
DUF4822 (PF16103) 2539 (5.6%) View
His_binding (PF02098) 1235 (2.7%) View
Lipocalin_5 (PF13924) 655 (1.4%) View
Lipocalin_4 (PF13648) 617 (1.4%) View
DUF3642 (PF12182) 487 (1.1%) View
Triabin (PF03973) 481 (1.1%) View
Svf1 (PF08622) 348 (0.8%) View
Lipocalin_7 (PF14651) 293 (0.6%) View
Lipocalin_8 (PF16585) 287 (0.6%) View
Lipocalin_3 (PF12702) 257 (0.6%) View
DUF4488 (PF14869) 219 (0.5%) View
VDE (PF07137) 158 (0.3%) View
ApoM (PF11032) 91 (0.2%) View
Nitrophorin (PF02087) 59 (0.1%) View
Total: 20 Total: 45381 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 15 interactions for this clan. More...

Interacting families
A B
ApoM ApoM
CrtC CrtC
His_binding His_binding
Lipocalin fn3
Lipocalin
Lipocalin_2 Lipocalin_2
Lipocalin_3 Lipocalin_3
Lipocalin_7 Lipocalin_7
MACPF Lipocalin
Nitrophorin Nitrophorin
NlpE NlpE
Transthyretin Lipocalin
Triabin Triabin
Trypsin Triabin
VDE VDE

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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