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39  structures 805  species 13  interactions 4627  sequences 71  architectures

Clan: Cargo_bd_muHD (CL0448)


Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor Add an annotation

Internalisation of diverse transmembrane cargos from the plasma membrane requires a similarly diverse array of specialized adaptors, this domain is the binding domain of these endocytioc adaptors. The muHD binds directly to the cytosolic tail of the Mid2 (for the transmembrane stress sensor protein Mid2) cargo protein and mediates Mid2 internalization [1]. These are all-beta proteins.

This clan contains 2 families and the total number of domains in the clan is 4627. The clan was built by P Coggill.

Literature references

  1. Reider A, Barker SL, Mishra SK, Im YJ, Maldonado-Baez L, Hurley JH, Traub LM, Wendland B;, EMBO J. 2009;28:3103-3116.: Syp1 is a conserved endocytic adaptor that contains domains involved in cargo selection and membrane tubulation. PUBMED:19713939 EPMC:19713939


This clan contains the following 2 member families:

Adap_comp_sub muHD

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Adap_comp_sub (PF00928) 3961 (85.6%) View
muHD (PF10291) 666 (14.4%) View
Total: 2 Total: 4627 Clan alignment

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 13 interactions for this clan. More...

Interacting families
Adap_comp_sub Adap_comp_sub
Adaptin_N Adap_comp_sub
Clat_adaptor_s Adap_comp_sub
DEP Adap_comp_sub
Dsh_C Adap_comp_sub
F-protein Adap_comp_sub


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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