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1093  structures 8610  species 8  interactions 70137  sequences 331  architectures

Clan: ClpP_crotonase (CL0127)


ClpP/Crotonase superfamily Add an annotation

This family includes several peptidases of peptidase clan SK as well as crotonase like proteins.

This clan contains 10 families and the total number of domains in the clan is 70137. The clan was built by A Bateman.

Literature references

  1. Kunin V, Chan B, Sitbon E, Lithwick G, Pietrokovski S; , J Mol Biol 2001;307:939-949.: Consistency analysis of similarity between multiple alignments: prediction of protein function and fold structure from analysis of local sequence motifs. PUBMED:11273712 EPMC:11273712
  2. Zhang H, Yang Z, Shen Y, Tong L; , Science 2003;299:2064-2067.: Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. PUBMED:12663926 EPMC:12663926


This clan contains the following 10 member families:

ACCA Carboxyl_trans CLP_protease ECH ECH_C MdcE Peptidase_S41 Peptidase_S49 Peptidase_S49_N SDH_sah

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ECH (PF00378) 26211 (37.4%) View
Carboxyl_trans (PF01039) 11662 (16.6%) View
Peptidase_S41 (PF03572) 9366 (13.4%) View
CLP_protease (PF00574) 9058 (12.9%) View
Peptidase_S49 (PF01343) 6794 (9.7%) View
ACCA (PF03255) 3540 (5.0%) View
ECH_C (PF13766) 1675 (2.4%) View
Peptidase_S49_N (PF08496) 1104 (1.6%) View
SDH_sah (PF01972) 404 (0.6%) View
MdcE (PF06833) 323 (0.5%) View
Total: 10 Total: 70137 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 8 interactions for this clan. More...

Interacting families
Peptidase_S49 Peptidase_S49
ECH Thiolase_N
CLP_protease CLP_protease
Peptidase_S41 PDZ
Carboxyl_trans Carboxyl_trans


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...