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1470  structures 25007  species 22  interactions 294181  sequences 519  architectures

Clan: ClpP_crotonase (CL0127)

Summary

ClpP/Crotonase superfamily Add an annotation

This family includes several peptidases of peptidase clan SK as well as crotonase like proteins.

This clan contains 10 families and the total number of domains in the clan is 294181. The clan was built by A Bateman.

Literature references

  1. Kunin V, Chan B, Sitbon E, Lithwick G, Pietrokovski S; , J Mol Biol 2001;307:939-949.: Consistency analysis of similarity between multiple alignments: prediction of protein function and fold structure from analysis of local sequence motifs. PUBMED:11273712 EPMC:11273712
  2. Zhang H, Yang Z, Shen Y, Tong L; , Science 2003;299:2064-2067.: Crystal structure of the carboxyltransferase domain of acetyl-coenzyme A carboxylase. PUBMED:12663926 EPMC:12663926

Members

This clan contains the following 10 member families:

ACCA Carboxyl_trans CLP_protease ECH_1 ECH_2 MdcE Peptidase_S41 Peptidase_S49 Peptidase_S49_N SDH_sah

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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Alignments

The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
ECH_1 (PF00378) 123859 (42.1%) View
Carboxyl_trans (PF01039) 44069 (15.0%) View
CLP_protease (PF00574) 38696 (13.2%) View
Peptidase_S49 (PF01343) 28674 (9.7%) View
Peptidase_S41 (PF03572) 27996 (9.5%) View
ACCA (PF03255) 15425 (5.2%) View
ECH_2 (PF16113) 7483 (2.5%) View
Peptidase_S49_N (PF08496) 5319 (1.8%) View
MdcE (PF06833) 1918 (0.7%) View
SDH_sah (PF01972) 742 (0.3%) View
Total: 10 Total: 294181 Clan alignment
 

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Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

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This tree shows the occurrence of the domains in this clan across different species. More...

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Interactions

There are 22 interactions for this clan. More...

Interacting families
A B
ACCA ACCA
Carboxyl_trans
Biotin_carb_C Carboxyl_trans
Biotin_lipoyl Carboxyl_trans
Carboxyl_trans ACCA
Biotin_lipoyl
Carboxyl_trans
CLP_protease CLP_protease
ECH_1 3HCDH
3HCDH_N
ECH_1
Response_reg
Thiolase_C
Thiolase_N
PD40 Peptidase_S41
PDZ_2 Peptidase_S41
Peptidase_S41 PD40
Peptidase_S41
Tricorn_C1
Peptidase_S49 Peptidase_S49
Tricorn_C1 Peptidase_S41
Tricorn_PDZ Peptidase_S41

Structures

For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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