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274  structures 7582  species 12  interactions 88083  sequences 3807  architectures

Clan: CoA-acyltrans (CL0149)


CoA-dependent acyltransferase superfamily Add an annotation

All characterised families in this clan are involved in CoA-dependent acyltransferase. All families have a characteristic HXXXD motif.

This clan contains 9 families and the total number of domains in the clan is 88083. The clan was built by RD Finn.


This clan contains the following 9 member families:

2-oxoacid_dh AATase Carn_acyltransf CAT Condensation PapA_C Transferase Tri3 WES_acyltransf

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Condensation (PF00668) 42895 (48.7%) View
2-oxoacid_dh (PF00198) 21401 (24.3%) View
Transferase (PF02458) 11853 (13.5%) View
Carn_acyltransf (PF00755) 5010 (5.7%) View
WES_acyltransf (PF03007) 4471 (5.1%) View
CAT (PF00302) 1106 (1.3%) View
AATase (PF07247) 1023 (1.2%) View
PapA_C (PF16911) 169 (0.2%) View
Tri3 (PF07428) 155 (0.2%) View
Total: 9 Total: 88083 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 12 interactions for this clan. More...

Interacting families
2-oxoacid_dh 2-oxoacid_dh
Carn_acyltransf Carn_acyltransf
Condensation AMP-binding
NO_synthase CAT
PP-binding Condensation
Transferase Transferase


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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