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13  structures 45  species 3  interactions 49  sequences 19  architectures

Clan: Colicin_D_E5 (CL0640)


Colicin D/E5 nuclease domain superfamily Add an annotation

This superfamily includes the nuclease domains from colicins that act up tRNA substrates.

This clan contains 2 families and the total number of domains in the clan is 49. The clan was built by A Bateman.


This clan contains the following 2 member families:

Colicin_D Colicin_E5

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Colicin_D (PF11429) 35 (71.4%) View
Colicin_E5 (PF12106) 14 (28.6%) View
Total: 2 Total: 49 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
Colicin_D Colicin_immun
Colicin_E5 ImmE5
ImmE5 Colicin_E5


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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