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310  structures 4947  species 3  interactions 18056  sequences 183  architectures

Clan: Cyclophil-like (CL0475)


Cyclophilin-like superfamily Add an annotation

This superfamily is characterised by being the core, closed, beta barrel of cyclophilin with complex topology, with some family members lacking the N-terminal strand of cyclophilin but retaining a closed barrel.

This clan contains 6 families and the total number of domains in the clan is 18056. The clan was built by P Coggill.


This clan contains the following 6 member families:

AHS1 Cyclophil_like DUF3830 DUF871 PIF Pro_isomerase

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
Pro_isomerase (PF00160) 13237 (73.3%) View
AHS1 (PF02682) 3092 (17.1%) View
DUF871 (PF05913) 1290 (7.1%) View
Cyclophil_like (PF04126) 235 (1.3%) View
DUF3830 (PF12903) 130 (0.7%) View
PIF (PF05092) 72 (0.4%) View
Total: 6 Total: 18056 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 3 interactions for this clan. More...

Interacting families
Cyclophil_like Cyclophil_like
Pro_isomerase Pro_isomerase


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

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