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96  structures 7661  species 4  interactions 27687  sequences 125  architectures

Clan: DAP_epimerase (CL0288)


DAP epimerase superfamily Add an annotation

This superfamily includes DAP epimerase and proline racemase as well as the PrpF protein. It has been suggested that this fold may have evolved from the HotDog fold [1].

This clan contains 4 families and the total number of domains in the clan is 27687. The clan was built by A Bateman.

Literature references

  1. Liger D, Quevillon-Cheruel S, Sorel I, Bremang M, Blondeau K, Aboulfath I, Janin J, van Tilbeurgh H, Leulliot N; , Proteins. 2005;60:778-786.: Crystal structure of YHI9, the yeast member of the phenazine biosynthesis PhzF enzyme superfamily. PUBMED:16021630 EPMC:16021630


This clan contains the following 4 member families:

DAP_epimerase PhzC-PhzF Pro_racemase PrpF

External database links

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DAP_epimerase (PF01678) 13853 (50.0%) View
PhzC-PhzF (PF02567) 7753 (28.0%) View
Pro_racemase (PF05544) 3283 (11.9%) View
PrpF (PF04303) 2798 (10.1%) View
Total: 4 Total: 27687 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There are 4 interactions for this clan. More...

Interacting families
DAP_epimerase DAP_epimerase
PhzC-PhzF PhzC-PhzF
Pro_racemase Pro_racemase
PrpF PrpF


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...