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9  structures 1536  species 1  interaction 5312  sequences 13  architectures

Clan: DUF1214 (CL0528)


DUF1214-like Add an annotation

Members of this clan usually appear in pairs on the same sequence. In cases where there is only a single example of the domain, there is often a second protein containing a single domain that is located sequentially along the chromosome. The crystal structure of pdb:2P3Y reveals that Pfam:PF06863 and Pfam:PF06742 come together to from a deep, positively charged pocket or cleft. Structural comparisons reveal that this may this pocket that may bind some form of carbohydrate. Conserved residues are predominantly found on the surface of the positively charged cleft [Jayaraman et al. personal communication].

This clan contains 2 families and the total number of domains in the clan is 5312. The clan was built by RD Finn.


This clan contains the following 2 member families:

DUF1214 DUF1254

Domain organisation

Below is a listing of the unique domain organisations or architectures from this clan. More...

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The table below shows the number of occurrences of each domain throughout the sequence database. More...

Pfam family Num. domains Alignment
DUF1214 (PF06742) 3048 (57.4%) View
DUF1254 (PF06863) 2264 (42.6%) View
Total: 2 Total: 5312 Clan alignment

Please note: Clan alignments can be very large and can cause problems for some browsers. Read the note above before viewing.

Family relationships

This diagram shows the relationships between members of this clan. More...

Species distribution

Tree controls


This tree shows the occurrence of the domains in this clan across different species. More...



There is 1 interaction for this clan. More...

Interacting families
DUF1254 DUF1214


For those sequences which have a structure in the Protein DataBank, we use the mapping between UniProt, PDB and Pfam coordinate systems from the MSD group, to allow us to map Pfam domains onto UniProt three-dimensional structures. The table below shows the mapping between the Pfam families in this clan, the corresponding UniProt entries, and the region of the three-dimensional structures that are available for that sequence.

Loading structure mapping...